CAMK2A antibody Host Goat
- Known as:
- CAMK2A (anti-) Host Goat
- Catalog number:
- 'AP08330PU-N
- Product Quantity:
- 0.1 mg
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CAMK2A antibody Host Goat
Related genes to: CAMK2A antibody Host Goat
- Gene:
- CAMK2A NIH gene
- Name:
- calcium/calmodulin dependent protein kinase II alpha
- Previous symbol:
- CAMKA
- Synonyms:
- KIAA0968, CaMKIINalpha
- Chromosome:
- 5q32
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-24
- Date modifiied:
- 2016-04-06
Related products to: CAMK2A antibody Host Goat
Related articles to: CAMK2A antibody Host Goat
- Chaihu Shugan San (CSS), a classical seven-herb formula from the Ming-dynasty text Jing-Yue Quanshu, is widely prescribed for depressive disorders in China. Previous preclinical studies reported antidepressant-like effects only after weeks of repeated administration, mostly in male animals. Whether a single dose of CSS can produce rapid antidepressant-like effects in female animals, and through what mechanism, remains unclear. - Source: PubMed
Publication date: 2026/09/22
Wu LeiCheng WenqingXiang HaokeZhu YapingJiang YiranWei ZixuanShao MengqiTian LiyuanSun YanLu Chao - To investigate the molecular mechanisms by which calcium signaling pathways regulate the paclitaxel resistance and the survival of oral squamous cell carcinoma (OSCC) cells. - Source: PubMed
Wang JunfengChen HongliChen JiaoFeng YunYuan YaoZhang Ping - CaMKIIα functional knockout mouse (K42R) showed substantial changes in the entrainment pattern of running-wheel (RW) rhythm to a short (LD6:18) but not to a long (LD18:6) photoperiod. In wild type mice (WT), entrainment to LD6:18 occurred at the light-off phase, whereas in most K42R entrainment took place at the light-on phase. These differences are well explained by lengthening of circadian period (τ) and compromising the couplings between the activity-onset and -end in K42R. Indeed, τ in K42R and WT were longer and shorter than 24 h, respectively, under the following constant darkness (DD). Without RW τ was lengthened in WT, whereas it was shortened in K42R. Similarly, activity time was lengthened in WT but shortened in K42R. Importantly, τ without RW was not different between the two genotypes, which were confirmed in naive mice. Tau and α returned to the pre-removal levels after RW re-introduction in both WT and K42R. These results indicate that the changes of behavioral rhythm in K42R are due to a lack of feedback effects of RW activity, which are mediated by CaMKIIα-dependent mechanisms. A two-oscillator model assuming involvement of CaMKIIα in the coupling between them successfully simulated the effects of RW activity in K42R. - Source: PubMed
Publication date: 2026/09/02
Yoshikawa TomokoHonma Ken-IchiTokuda IsaoHonma Sato - β-Amyloid precursor protein (APP), an amyloid β-peptide (Aβ) generating protein, plays a central role in Alzheimer's disease (AD). Its intracellular trafficking and proteolytic processing are precisely regulated, but the mechanisms remain elusive. Here, we identified LAMTOR1 as a novel APP intracellular domain binding partner that sorts APP from early endosomes to late endosomes. Knockout of LAMTOR1 decreased APP trafficking to late endosomes, which promoted its amyloidogenic processing on early endosomes, resulting in increased Aβ. Conditional knockout of LAMTOR1 in Camk2a-expressing neurons impaired memory function in AD mouse model. Furthermore, the targeting of APP to late endosomes is mediated by adaptor protein complex 3 (AP-3). AP-3 bound to LAMTOR1, and its depletion caused accumulation of LAMTOR1 and APP within early endosomes, subsequently increasing Aβ. Thus, LAMTOR1 functions as a regulator of APP trafficking to late endosomes and may serve as a potential therapeutic target for AD. - Source: PubMed
Publication date: 2026/08/26
Zhou ChenqianCao WenyuanCong RixuShan ChunyanTian YongluXu SizhengFeng WeiranLi YuanjunWang XunTeng JunlinZheng PengliHuang NingChen Jianguo - Acute myeloid leukemia (AML) exhibits heterogeneous outcomes and lacks reliable prognostic markers. As a critical regulator of cell fate, the prognostic value of calcium signaling in AML requires investigation. This study aimed to construct a calcium-related gene (CRG)-based prognostic model for AML. Differential analysis on RNA-seq data was conducted for AML from The Cancer Genome Atlas and Gene Expression Omnibus (GEO). Intersecting differentially expressed genes and CRGs yielded AML-associated differentially expressed CRGs (DECRGs). A prognostic model was developed using univariate/multivariate Cox regression and least absolute shrinkage and selection operator (LASSO) and validated in a GEO dataset. Bioinformatics analyses explored the links between risk groups and immune characteristics, genomic mutations, and drug sensitivity. Key genes' effects on cell proliferation, apoptosis, and differentiation were verified in vitro using CCK-8 assay, colony formation assay, and flow cytometry. The 13-DECRG-based model distinguished high- and low-risk patients in both training and validation cohorts, with high-risk patients showing a worse prognosis. The risk score was an independent prognostic factor. Immune analysis revealed a unique immune microenvironment for the high-risk group. CAMK2A overexpression inhibited cell proliferation and colony-forming ability, promoted cell apoptosis, and induced an increased proportion of CD11b- and CD14-positive cells. In vitro experiments indicated CAMK2A-induced suppression of AML cells' malignant phenotype by activating the P53 signaling pathway. An AML CRG-based model with favorable risk stratification performance was constructed. In vitro experiments revealed CAMK2A-induced inhibition of the malignant phenotype via suppressing proliferation, promoting apoptosis, and facilitating myeloid differentiation in AML cells. This study provides novel evidence for understanding CRGs in AML as well as the potential functions of CAMK2A. - Source: PubMed
Publication date: 2026/08/25
Duan JingZhang HuChu JunjieDuan Xiangdong