Cdx2 Clone 'SP54 antibody Host Rabbit
- Known as:
- Cdx2 Clone 'SP54 (anti-) Host Rabbit
- Catalog number:
- 'AM11120PU-N
- Product Quantity:
- 1.0 ml
- Category:
- -
- Supplier:
- ACR
- Gene target:
- Cdx2 Clone 'SP54 antibody Host Rabbit
Related genes to: Cdx2 Clone 'SP54 antibody Host Rabbit
- Gene:
- CDX2 NIH gene
- Name:
- caudal type homeobox 2
- Previous symbol:
- CDX3
- Synonyms:
- -
- Chromosome:
- 13q12.2
- Locus Type:
- gene with protein product
- Date approved:
- 1994-09-07
- Date modifiied:
- 2015-08-24
- Gene:
- CYCSP49 NIH gene
- Name:
- CYCS pseudogene 49
- Previous symbol:
- CYCSP54
- Synonyms:
- HCP49
- Chromosome:
- Yq11.23
- Locus Type:
- pseudogene
- Date approved:
- 2005-04-29
- Date modifiied:
- 2019-01-21
- Gene:
- PPP3CB-AS1 NIH gene
- Name:
- PPP3CB antisense RNA 1 (head to head)
- Previous symbol:
- -
- Synonyms:
- USP54-AS1
- Chromosome:
- 10q22.2
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2014-06-16
- Date modifiied:
- 2014-06-16
Related products to: Cdx2 Clone 'SP54 antibody Host Rabbit
Related articles to: Cdx2 Clone 'SP54 antibody Host Rabbit
- Cribriform morular thyroid carcinoma (CMTC) is a rare neoplasm more common in young euthyroid females, usually associated with familial adenomatous polyposis (FAP) syndrome, but also presenting as sporadic cases. These tumors result from the activation of the WNT/β-catenin signaling pathway, usually through germline APC gene mutations in FAP-associated disease, while sporadic cases may exhibit somatic mutations in APC, CTNNB1, and AXIN1. Additional possible molecular events include somatic mutations in KRAS, PIK3CA, KMT2C, KMT2D, TERT promoter or RET rearrangements. BRAF mutations do not occur. We describe a sporadic case of high-grade CMTC presented in a 44-year-old female with a large multilobulated, unifocal mass in the right thyroid lobe. The tumor showed the typical cribriform and morular patterns, high grade features (Ki-67 proliferative index of 20% and foci of necrosis), marked vascular invasion and regional lymph node metastases. The tumor cells were immunoreactive for keratin (KRT) clone CKAE1/AE3, KRT7, and TTF1/NKX2, with aberrant (nuclear and cytoplasmic) expression of β-catenin, but negative for thyroglobulin and calcitonin. CDX2 was detected exclusively in the morular structures. The somatic APC p.(Thr621Leufs*9) oncogenic variant and the somatic TERT promoter - 124 (C228T) oncogenic variant were found, in line with the tumor type and tumor grade respectively; but, for the first time, EWSR1 gene rearrangement was also detected, expanding the molecular spectrum of this uncommon entity. - Source: PubMed
Publication date: 2026/06/19
Alorjani Mohammed SayelSobrinho-Simões ManuelAl-Oqaily Ayat NaderAlsinglawi Dania JamalHeis Hussein AliCameselle-Teijeiro José Manuel - A rare subset of somatic tumors shows a striking resemblance to yolk sac tumors (YSTs) of germ cell origin, including somatic carcinomas with YST/enteroblastic differentiation, fetal lung adenocarcinomas (FLACs), and YSTs in older (≥ 40 years) females. These somatic tumors express markers such as SALL4, glypican 3 (GPC 3) and alpha-fetoprotein (αFP). However, it is currently unclear to what extent they express FOXA2, HNF1β, and SOX17, which are pioneer transcription factors and key drivers of YST differentiation and stain the vast majority of chemotherapy-naïve YSTs of germ cell origin. Therefore, a multi-institutional series of seven somatically derived "YST-like" tumors was assembled and evaluated with a comprehensive panel of YST related markers (SALL4, FOXA2, HNF1β, SOX17, αFP, GATA3, and CDX2), to evaluate the potential involvement of FOXA2, HNF1β, and SOX17 in the biology of these tumors. FOXA2 and HNF1β were positive in all (7/7, 100%) YST-like tumors, followed by CDX2 (6/7, 85.7%) and SALL4 (5/7, 71.4%). In contrast, SOX17, GATA3, αFP, and GPC3 were positive in fewer cases, and showed lower percentages and intensities. Four of seven (57.1%) YST-like tumors showed synchronous/accompanying somatic neoplastic components: one clear cell carcinoma of the ovary, two urothelial carcinomas of the bladder, and one invasive non-mucinous (conventional) adenocarcinoma of the lung. HNF1β stained all these components (4/4, 100%), and all of them (4/4, 100%) stained for at least two of the YST markers evaluated (range: 2-4). In conclusion, our results support the use of an immunohistochemical panel to diagnose YST-like tumors, considering not only the most frequently expressed makers (FOXA2 and HNF1β), but also the potential expression (particularly of HNF1β) by the associated somatic neoplastic components lacking an overt YST phenotype. The consistent expression of FOXA2 and HNF1β (but not SOX17) in our cohort underscores the phenotypic overlap between YST-like tumors and YSTs of germ cell origin (type II), including shared expression of multiple pioneer transcription factors which drive the YST phenotype. - Source: PubMed
Publication date: 2026/06/18
Ricci CostantinoDe Leo AntonioGrillini MarcoOrsatti AgneseLobo JoãoFernanda-Pontes FernandaTavares Nuno TiagoVieira JoanaAmbrosi FrancescaGrillini AlessiaFranchini EugeniaVasuri FrancescoNosseir SofiaMollica VeronicaMassari FrancescoAcosta Andres MartinFiorentino MichelangeloLi HuiliBaraban Ezra - Ovarian cancer is one of the deadliest female gynaecological cancers, known to have high metastatic ability and telomerase reactivation. The current study aims to explore the influence of exogenous Kisspeptin-10 (KP-10) on the SP1-ZEB1-hTERT pathway in SKOV-3 ovarian cancer cell lines using both in vitro and computational techniques. KP-10 significantly inhibited SKOV-3 proliferation, migration, and invasion at a dose-dependent level with an IC₅₀ of 72.28 nM. The molecular mechanisms showed the ability of KP-10 to affect the regulation of important transcriptional factors such as SP1, CDX2, GATA2, FLI1, and ZEB1 and hTERT expression, indicating telomerase-related oncogenic signaling modulation. Besides, KP-10 influenced the expression of tumor suppressive microRNAs, including miR-200, miR-345, and miR-577 which are known to inhibit epithelial-mesenchymal transition, invasion, and development of cancer. The bioinformatics analysis of the KISS1 promoter showed multiple binding sites of SP1, CDX2, GATA2, FLI1, among others, indicating the transcription network in KISS1 regulation. Taken together, this paper shows the KP-10-mediated modulation of transcriptional factors involved in the SP1-ZEB1-hTERT pathway, inhibiting proliferative and metastatic phenotypes of ovarian cancer cells. - Source: PubMed
Publication date: 2026/06/11
Shah HetviThomas AbinPandya Parth - Mucinous cystic tumors of the renal pelvis or pyelocaliceal system are extremely rare neoplasms and often mimic complicated renal cysts. Surgical resection is recommended due to the risk of malignant transformation. In September 2023, imaging revealed a cystic lesion measuring 106×93 mm in the right kidney of a 68-year-old male patient, reported as Bosniak type III. The patient underwent right radical nephrectomy. Pathological examination revealed a unilocular cystic lesion lined with mucinous epithelium showing no atypia. Immunohistochemically, epithelial cells were CDX2 positive and PAX8, GATA3, and p63 negative. Findings were consistent with mucinous cystadenoma. No recurrence or metastasis was observed during 18 months of follow-up. The diagnosis of renal mucinous cystadenoma is challenging with preoperative imaging, and the definitive diagnosis is made by postoperative histopathology. Surgical resection and close follow-up are necessary due to the risk of malignant transformation. - Source: PubMed
Publication date: 2026/05/12
Karadeniz Muhammed NDemir MehmetOtlu HasanAlmuhammed MuhammedCoskun Ferhat - Intestinal SMARCA4-deficient undifferentiated carcinoma (SMARCA4-DUC) is a rare and highly aggressive malignancy. Its clinicopathological features remain poorly defined. No standardized treatment has been established. - Source: PubMed
Publication date: 2026/06/13
Ma WenjingZhou ShendaHuang YongtaTang XiaofengWang Shimei