CD43 / Leukosialin Clone 'SP55 antibody Host Rabbit
- Known as:
- CD43 / Leukosialin Clone 'SP55 (anti-) Host Rabbit
- Catalog number:
- 'AM11106PU-S
- Product Quantity:
- 0.1 ml
- Category:
- -
- Supplier:
- ACR
- Gene target:
- CD43 / Leukosialin Clone 'SP55 antibody Host Rabbit
Related genes to: CD43 / Leukosialin Clone 'SP55 antibody Host Rabbit
- Gene:
- GNAS NIH gene
- Name:
- GNAS complex locus
- Previous symbol:
- GNAS1
- Synonyms:
- NESP55, NESP, GNASXL, GPSA, SCG6, SgVI
- Chromosome:
- 20q13.32
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-29
- Date modifiied:
- 2016-10-05
- Gene:
- GORASP2 NIH gene
- Name:
- golgi reassembly stacking protein 2
- Previous symbol:
- -
- Synonyms:
- GRASP55, GRS2, GOLPH6
- Chromosome:
- 2q31.1
- Locus Type:
- gene with protein product
- Date approved:
- 2002-05-23
- Date modifiied:
- 2015-11-09
- Gene:
- SPN NIH gene
- Name:
- sialophorin
- Previous symbol:
- -
- Synonyms:
- LSN, CD43, GPL115
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1988-08-31
- Date modifiied:
- 2016-07-19
Related products to: CD43 / Leukosialin Clone 'SP55 antibody Host Rabbit
Related articles to: CD43 / Leukosialin Clone 'SP55 antibody Host Rabbit
- Solid pseudopapillary neoplasm of pancreas (SPN) is a rare low-grade malignant pancreatic tumor. The morphology of SPN exhibits considerable diversity. Accurate diagnosis is crucial due to the morphological similarity of SPN to other pancreatic tumors, including pancreatic neuroendocrine tumors (NETs), acinar cell carcinoma (ACC) and pancreatoblastoma (PB), especially in the preoperative biopsy specimen. Image-guided biopsy techniques are essential for preoperative diagnosis, but the limited tissue in biopsy samples can complicate the diagnosis of SPN from other tumors. In this study, we evaluate the diagnostic utility of ATP Binding Cassette Subfamily D Member 1 (ABCD1), a novel immunohistochemical (IHC) marker previously identified in surgically resected SPN specimens, for distinguishing SPN in biopsy samples. We analyzed biopsy samples from a cohort of 55 SPN patients (55 biopsy samples and 6 paired surgical resected samples) and compared them with samples from 61 pancreatic ductal adenocarcinoma (PDAC), 90 NET, 13 intraductal papillary mucinous neoplasm (IPMN), 7 ACC and 3 PB patients from four institutions. Our findings show that ABCD1 positively marks SPN biopsy samples consistently as surgical resected samples, with 100% overall positivity and 96.37% exhibiting moderate to strong expression. In contrast, moderate to strong ABCD1 expression was significantly lower in PDAC (3.28%) and NET (6.66%). However, strong expression was observed in 57.14% of acinar cell carcinomas (ACC). Furthermore, ABCD1 complements β-catenin in cases where nuclear β-catenin staining is ambiguous (100% ABCD1 positivity). ROC curve analysis revealed that ABCD1 exhibits excellent diagnostic performance for distinguishing SPN from other pancreatic tumors, achieving a sensitivity of 96.36% and a specificity of 93.10% , establishing it a reliable complementary diagnostic marker in biopsy samples. These results suggest that ABCD1 could serve as a valuable tool for the accurate preoperative diagnosis of SPN, thereby improving clinical management and patient outcomes. - Source: PubMed
Publication date: 2026/04/17
Liu YuanhaoPeng JunyaHe RuizheXue XiaoweiCui JieLi MengjieLiu Ying-AoXu WanniGao XiaohongWang YingmeiZhang ZheLu HaizhenSong ZhigangHu PeizhenZhao YupeiWang Wenze - Parenteral nutrition (PN) is fundamental in the management of premature infants hospitalized in neonatal intensive care units (NICUs). Traditionally, standardized PN (SPN) has been recommended for most newborns due to safety, faster initiation, and reduced risk of prescribing errors. However, individualized PN (IPN) remains necessary in cases of metabolic instability or prolonged PN. Recently, AI-based models, such as the TPN2.0 algorithm, have emerged as potential tools to enhance precision, safety, and clinical outcomes in PN by combining standardization and personalization. The aim of this review is to summarize and critically discuss current evidence regarding standardized, individualized, and AI-based approaches to PN in premature infants hospitalized in NICUs. Despite guidelines, practice varies, and the emerging evidence for AI needs critical synthesis. This narrative review is based on a focused, critical appraisal of the available literature. A nonsystematic search of PubMed/MEDLINE, Wiley Online Library, ScienceDirect, and Google Scholar was conducted to identify relevant articles. Additional sources included international clinical guidelines and consensus statements. The search focused on publications addressing standardized, individualized, and AI-supported PN in neonatal and pediatric intensive care settings. Selected studies were analyzed qualitatively with emphasis on clinical outcomes, nutritional adequacy, safety profiles, and practical implementation aspects. Due to the heterogeneity of study designs and outcomes, a formal systematic review methodology and meta-analysis were not performed. Across multiple studies, SPN has been found to provide adequate macronutrient and electrolyte intake for most NICU patients, enabling faster initiation of PN and reducing prescribing errors. SPN often resulted in improved early protein, glucose, calcium, and phosphate delivery compared with IPN, with fewer electrolyte disturbances and comparable or better growth outcomes. Evidence supporting IPN benefits has been inconsistent and limited primarily to metabolically unstable or complex cases. AI-based PN (TPN2.0) demonstrated promising results, with physicians rating its recommendations higher than standard prescriptions. In infants whose clinically prescribed PN differed most from AI recommendations, higher morbidity, including NEC, was observed compared with AI-guided formulations. The algorithm reduced formulation subjectivity, streamlined workflow, and enabled rapid, guideline-adherent PN prescription. Early evidence suggests a potential association with reduced rates of mortality, cholestasis, sepsis, and NEC with the use of AI-supported PN strategies. SPN remains the safest and most efficient first-line approach for most premature infants, ensuring rapid initiation and reducing prescription-related risks. IPN continues to be essential for selected high-risk patients with complex metabolic needs. Emerging AI-based systems such as TPN2.0 may bridge these approaches by delivering personalized yet SPN formulations, improving safety, efficiency, and potentially clinical outcomes. Further high-quality prospective trials are needed to validate these findings and support the integration of AI into routine NICU nutritional practice. - Source: PubMed
Publication date: 2026/03/16
Walendziak WeronikaDomosud KarolinaMalczyk AnnaZienkiewicz DamianMakulec GabrielaŚciebura KacperOstaszewska MagdalenaMordal NataliaWiśniewska WiktoriaMajchrzyk Milena - Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare, low-grade malignant epithelial tumor that may originate from embryonic multipotent stem cells. The prevalence of metastatic SPN is approximately 9% to 15%, most commonly in the liver and peritoneum. Delayed ovarian metastasis during pregnancy is exceedingly rare, pregnancy may promote the progression and pose a life-threatening risk. - Source: PubMed
Publication date: 2026/04/11
Jie RuixiaDai XiaominLei HuanPeng Fang - Neural circuits exhibit remarkable plasticity in response to varying intensities of sensory input. The temporal dynamics and cellular mechanisms underlying this plasticity are highly heterogeneous and possibly specific to individual circuits. Excessive noise exposure causes damage of peripheral auditory structures, such as cochlear hair cells and auditory nerve fibres, reducing afferent projection to downstream structures and initiating cascades of long-lasting compensatory changes in central auditory circuits. Amongst these changes, increased neuronal excitability, elevated spontaneous firing and increased neural gain were reported across multiple structures between the cochlear nucleus and auditory cortex. However, these findings primarily involved neurons that were responsive to sound onset (ON) and driven by excitation. Much less is known about the impact of noise exposure on neurons that are selectively activated by sound offset (OFF) and are driven by inhibition. We addressed this gap in knowledge by investigating the effects of noise exposure on intrinsic membrane properties, synaptic input patterns and sound-evoked activity in superior paraolivary nucleus (SPN) neurons, which are a population of neurons specialized for encoding sound offset. Immediately after noise exposure, SPN neurons were unresponsive to sound offset. Within the next 24 h, we observed a significant increase in the number of inhibitory synaptic terminals impinging upon SPN neurons, which was corroborated by elevated frequencies and amplitudes of inhibitory postsynaptic currents. At the same time, SPN neurons exhibited higher intrinsic excitability. Together, these changes encouraged recovery of sound-evoked OFF responses 24 h following noise exposure, suggesting circuit-specific compensatory mechanisms that enable sound OFF encoding soon after peripheral auditory insult. KEY POINTS: Sound-offset (OFF) responses mark the critical temporal boundary when a sound terminates; this enables encoding of sound duration and the detection of gaps in sounds and calls. In the mouse model, OFF responses are generated de novo in the superior paraolivary nucleus by combining sound-evoked inhibitory input with the intrinsic membrane properties of the neurons. The impact of noise over-exposure on these OFF responses and its implications for subsequent auditory processing is not well understood. Combining patch-clamp recording, immunohistochemistry and in vivo electrophysiology, we show that superior paraolivary nucleus neurons exhibit increased excitability and enhanced inhibition following noise over-exposure. These compensatory changes help to mediate early recovery of sound OFF responses to loud stimuli, despite the loss of auditory sensitivity at lower sound intensities. - Source: PubMed
Publication date: 2026/04/16
Stancu MihaiRajaram EzhilarasanKroeger Joseph AGrothe BenediktKopp-Scheinpflug Conny - Previous research has shown that effort expenditure influences feedback processing in prosocial behavior. However, it remains unclear whether effort enhances or reduces feedback expectations and evaluations in prosocial behavior. Therefore, using event-related potentials (ERP) and multivariate pattern analysis (MVPA), the current study employed a modified prosocial effort task to examine how effort separately affects feedback expectation and evaluation in prosocial behavior. Behaviorally, high effort (vs. low effort) reduced participants' satisfaction when the beneficiary was another person, no such effect was observed when the beneficiary was the self. On the electrophysiological level, during the anticipation stage, the stimulus-preceding negativity (SPN) was more negative under high effort (vs. low effort) conditions. Conversely, during the evaluation stage, the feedback P300 (Fb-P3) and late positive potential (LPP) exhibited smaller responses after exerting high effort (vs. low effort). Moreover, the N2 and theta power were larger when the beneficiary was another person (vs. the self). MVPA revealed that effort distinguishing could be reliably decoded from electroencephalography (EEG) signals, regardless of whether the beneficiary was the self or another person. Taken together, our findings suggest that effort expenditure enhances feedback expectations but reduces subsequent feedback evaluations in prosocial behavior. - Source: PubMed
Publication date: 2026/04/14
Han JixingHuang XiaoyangWu NingxinXi LinXu HuiyiZhang Entao