MIRSKY FIXATIVE 10X CONC
- Known as:
- MIRSKY FIXATIVE 10X CONC
- Catalog number:
- HS-102-200ML 10 X CON
- Product Quantity:
- 200ML
- Category:
- -
- Supplier:
- NatDiag
- Gene target:
- MIRSKY FIXATIVE 10X CONC
Related genes to: MIRSKY FIXATIVE 10X CONC
- Gene:
- DDX11-AS1 NIH gene
- Name:
- DDX11 antisense RNA 1
- Previous symbol:
- -
- Synonyms:
- CONCR, SCAT4
- Chromosome:
- 12p11.21
- Locus Type:
- RNA, long non-coding
- Date approved:
- 2012-06-30
- Date modifiied:
- 2018-08-03
Related products to: MIRSKY FIXATIVE 10X CONC
(10x) PBS solution without Ca2+, Mg2+(10x) PBS-LOsung ohne Ca2+, Mg2+(10x) PBS_solution without Ca2+, Mg2+0.5 - 10ul pipette tips, extended length, 5 packs per case (10 racks of 96 per pack)0.5 - 10ul pipette tips, extended length, bulk pack of 1000, 20 packs per case0.5 - 10ul pipette tips, extended length, case of 19,200 racked tips (supplied in 20 packs containing 10 x 96 racks)0.5 - 10ul pipette tips, extended length, case of 19,200 racked tips (supplied in 5 packs containing 10 x 96 racks)0.5 - 10ul pipette tips, extended length, case of 20,000 tips (supplied in 20 bulk packs x 1,000)0.5 - 10ul pipette tips, extended length, case of 20,000 tips (supplied in 20 bulk packs x 1,000)0.5 _ 10ul pipette tips, extended length, case of 19,200 racked tips (supplied in 20 packs containing 10 x 96 racks)0.5 _ 10ul pipette tips, extended length, case of 20,000 tips (supplied in 20 bulk packs x 1,000)0.5% Trypsin-EDTA Solution,10X No Phenol Red, Sterile0.5% Trypsin-EDTA Solution,10X No Phenol Red, Sterile0.5% Trypsin-EDTA Solution,10X No Phenol Red, Sterile1,000 Units of Taq DNA Polymerase, Concentration = 5 Units_ul 10X Combination Reaction Buffer Related articles to: MIRSKY FIXATIVE 10X CONC
- Hepatocellular carcinoma (HCC) continues to be a major cause of cancer associated deaths worldwide, highlighting the need for new prognostic biomarkers and treatment strategies. Triaptosis, a recently characterized mode of regulated cell death, has shown potential as a therapeutic target in various malignancies, including HCC. Nevertheless, how long non-coding RNAs (lncRNAs) regulate triaptosis, as well as their function in HCC, is still not well understood. This study integrates bioinformatics and functional validation to delineate the interplay between lncRNAs and triaptosis in HCC progression. Firstly, we confirm that pharmacologically inducing triaptosis, a process centrally mediated by ROS accumulation, with menadione sodium bisulfite (MSB) can inhibit HCC growth both in vitro and in vivo. Furthermore, single-cell RNA sequencing identifies a specific elevation of the triaptosis-related gene in malignant hepatocytes. Through systematic bioinformatics analysis of TCGA data, we develop a 5-lncRNA prognostic signature (, , , , ) with superior predictive power over conventional clinical parameters. Strikingly, functional studies reveal that acts as a crucial oncogenic driver and its depletion suppresses proliferation, migration, and invasion while sensitizing cells to triaptosis via -mediated PI(3)P catabolism. Collectively, our study confirms that triaptosis is a therapeutically targetable signaling in HCC and proposes as a biomarker and therapeutic target, offering new insights into lncRNA-mediated regulation of cell death for precision oncology. - Source: PubMed
Publication date: 2025/11/07
Liu XiaolongZhuang ZiyunCheng JiaxiLi YujieLi DuguangShi ZhaoqiYang JingFan XiaoxiaoLin Hui - Glioma, as the most lethal primary brain malignancy with poor prognosis, requires further elucidation on the functional role of long noncoding RNA (lncRNA) DDX11 antisense RNA 1 (DDX11-AS1) in its pathogenesis, despite its established oncogenic functions in other cancers. Therefore, this study sought to characterize the oncogenic role and molecular mechanism of DDX11-AS1 in glioma. - Source: PubMed
Publication date: 2025/09/26
Wang JianweiYang XinzhiLin LvbiaoYu JianboMao Jie - - Source: PubMed
Publication date: 2025/08/12
- Inflammatory bowel disease (IBD) is a chronic and recurrent autoimmune condition. Numerous studies have reported that non-coding RNA, especially long non-coding RNA (lncRNA), plays a significant role in the regulation of IBD. This study sought to investigate the expression of lncRNA DDX11-antisense RNA 1 (DDX11-AS1) in IBD and its potential diagnostic value, while also evaluating the influence of DDX11-AS1 on the functionality of colorectal mucosal cells. - Source: PubMed
Publication date: 2025/04/16
Xiong TanweiWang XiuliLi JiaLi Fangfang - This study aims to investigate the expression, function, and mechanism of action of the small protein DDX11 antisense RNA 1 - open reading frame (DDX11-AS1-ORF), encoded by the long non-coding RNA (lncRNA) DDX11 antisense RNA 1 (DDX11-AS1), in the progression of colorectal cancer (CRC). The expression levels of DDX11-AS1 were assessed by quantitative reverse transcription polymerase chain reaction (qRT-PCR) analysis in 10 pairs of colorectal cancer tissues and corresponding non-tumor tissues. Functional evaluations of DDX11-AS1 and DDX11-AS1-ORF were conducted using cell counting kit-8 (CCK8) assays, colony formation assays, Transwell migration assays, and in vitro tube formation assays. The coding potential of DDX11-AS1 was validated by western blot and immunofluorescence. The activation of the p38 mitogen-activated protein kinase (p38-MAPK) pathway by DDX11-AS1-ORF through VEGFA was analyzed using western blot. The results showed that DDX11-AS1 was significantly upregulated in colorectal cancer tissues and cells, promoting cancer cell proliferation, migration, and angiogenesis. DDX11-AS1 translated into a functional small protein, DDX11-AS1-ORF, which independently enhanced the malignant behaviors of tumor cells. DDX11-AS1-ORF promoted colorectal cancer progression by activating the p38-MAPK signaling pathway through Vascular Endothelial Growth Factor A (VEGFA). The critical role of the p38-MAPK pathway in DDX11-AS1-ORF mediated tumor promotion was confirmed using the p38-MAPK pathway inhibitor SB203580. In conclusion, the small protein DDX11-AS1-ORF, encoded by DDX11-AS1, plays a crucial role in the development of colorectal cancer by promoting tumor proliferation, migration, and angiogenesis through the activation of VEGFA and the p38-MAPK signaling pathway. These findings provide a novel potential target for molecular targeted therapy in colorectal cancer. - Source: PubMed
Publication date: 2025/04/15
Cheng YuanfangDong JiajieShang KaiZhang LejingChen YongweiLi RihuiLi ZhaoxiZhang ZheyingWang Yajuan