PureHelix™ Genomic Prep Kit [Animal] (Solution based)
- Known as:
- PureHelix™ Genomic Prep Kit [Animal] (Solution based)
- Catalog number:
- GSA400
- Product Quantity:
- 400 preps/kit
- Category:
- -
- Supplier:
- NanoHelix
- Gene target:
- PureHelix™ Genomic Prep Kit [Animal] (Solution based)
Related genes to: PureHelix™ Genomic Prep Kit [Animal] (Solution based)
- Gene:
- PREP NIH gene
- Name:
- prolyl endopeptidase
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 6q21
- Locus Type:
- gene with protein product
- Date approved:
- 1996-03-12
- Date modifiied:
- 2016-10-05
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- Lactosucrose is a functional trisaccharide with significant prebiotic potential. However, its enzymatic synthesis from sucrose and lactose is often limited by glucose accumulation, which shifts the reaction equilibrium toward hydrolysis. In this study, we developed an efficient preparative production system for lactosucrose by integrating -derived levansucrase with an invertase-deficient ATCC 56741. Unlike conventional wine yeasts, the selected strain preferentially reduced glucose while minimizing sucrose and lactosucrose degradation under the tested conditions, thereby maintaining favorable conditions for transfructosylation. The integrated system was optimized by evaluating various relative proportions of enzyme activity and yeast biomass standardized by cell density. Under the optimized yeast-dominant condition (activity-to-biomass ratio of 1:3), a maximum lactosucrose concentration of 128.2 g/L was achieved. Furthermore, the biological removal of glucose may simplify downstream processing by reducing byproduct interference. Unlike glucose oxidase-based systems, which generate gluconic acid and require pH control, the present approach utilizes biological glucose removal without introducing additional acidic byproducts. These results suggest that the integrated levansucrase-yeast system is a promising preparative-scale strategy for lactosucrose production. - Source: PubMed
Publication date: 2026/05/19
Han Woo-CheulLee Je-HyukJang Ki-Hyo - We developed a pre-exposure prophylaxis (PrEP) shared decision-making tool to support people who could benefit from PrEP in reaching their prevention goals and preferences when considering two effective PrEP modalities, oral or long-acting injectable (LAI) PrEP, in partnership with their healthcare providers (HCPs). This 2-phase study included formative research to develop a PrEP shared decision-making tool prototype followed by a pilot study to determine prototype acceptability. For the formative phase, we conducted semi-structured qualitative in-depth interviews with a diverse sample of people who could benefit from PrEP (n = 41) and HCPs (n = 20) in two community-based sites in Washington, DC, prior to and shortly after LAI PrEP became available in December 2021. Insights from in-depth interviews informed development of a PrEP shared decision-making tool prototype in both English and Spanish. This prototype was piloted in one-on-one mock clinical encounters with 37 people who could benefit from PrEP and 11 HCPs, in the two DC sites and at a university-affiliated clinic in Chapel Hill, North Carolina. After these encounters, people who could benefit from PrEP and HCPs were interviewed independently about acceptability of the prototype's language, visuals, content and flow as well as the usability, utility, and feasibility of the prototype to support informed shared decision-making. In the formative phase, people who could benefit from PrEP had low awareness of and high interest in LAI PrEP. They and HCPs agreed that side effects and efficacy should be a primary focus of a PrEP shared decision-making tool. Participants in the mock clinical encounters found that the prototype filled information gaps, supported shared decision-making regardless of an individual's experience with PrEP, and systematized, streamlined and normalized conversations around PrEP choice. Testing the effectiveness of the prototype in a larger-scale evaluation is highly warranted as the field seeks to address ongoing inequities in PrEP uptake. - Source: PubMed
Publication date: 2026/05/19
Davis Wendy WMantsios AndreaMetzner Aimee ATalan AliKwait JennaferRodriguez Humberto GonzalezKarver Tahilin SanchezWilhite DanielBarker SuyannaSuarez AngelaFernandez RicardoRodriguez-Diaz Carlos ETaggart TamaraOglesby AlanWohl DavidBarrington ClareKerrigan Deanna - Chemsex, sexual activity under the influence of psychoactive substances, remains a major public health concern for men who have sex with men (MSM) globally. In Malaysia's conservative context, the convergence of chemsex and HIV transmission presents complex challenges. This narrative review examines how the Covid-19 pandemic and extended lockdown disrupted HIV services and intensified psychosocial stressors, amplifying chemsex, HIV, and mental health issues among Malaysian MSM. - Source: PubMed
Publication date: 2026/05/19
Thain Benjamin Km - Migrant women account for a substantial proportion of new HIV diagnoses in Europe, yet remain underrepresented in HIV prevention research. Little is known about how legal status and national policy context shape engagement with PrEP among migrant women, particularly those without secure documentation. We assessed the PrEP cascade and HIV prevention preferences among migrant women, examining how legal status, sex work engagement and national reimbursement policies drive inequities in access. - Source: PubMed
Publication date: 2026/05/19
Wang HaoyiFlaherty-Gupta AnneMajdoub HalaSesange EdwinIsip KimLubnow JustineSanchez Pedro BarriosPavanello LindaErevbenagie-Johnbull EtinosaPetry LillianGooding EmmaAnkiersztejn-Bartczak MagdalenaTriantafyllidou StavroulaPiercy AnnJonas Kai JOnyango DenisZimmermann Hanne M L - Hospital surge capacity is pivotal for disaster response, yet the effectiveness of assessment and planning tools remains underexplored. - Source: PubMed
Publication date: 2026/05/19
Dinar Hisham Hassan AliOthman Omer Abdel FattahHubloue Ives