Anti-Mouse CD309 (FLK1) PE 50 ug
- Known as:
- Antibody toMouse CD309 (FLK1) PE 50 ug
- Catalog number:
- 12-5821-81
- Category:
- -
- Supplier:
- eBioscience
- Gene target:
- Anti-Mouse CD309 (FLK1) 50
Related genes to: Anti-Mouse CD309 (FLK1) PE 50 ug
- Gene:
- KDR NIH gene
- Name:
- kinase insert domain receptor
- Previous symbol:
- -
- Synonyms:
- FLK1, VEGFR, VEGFR2, CD309
- Chromosome:
- 4q12
- Locus Type:
- gene with protein product
- Date approved:
- 1991-07-10
- Date modifiied:
- 2019-04-23
Related products to: Anti-Mouse CD309 (FLK1) PE 50 ug
Related articles to: Anti-Mouse CD309 (FLK1) PE 50 ug
- Arboviruses transmitted by Aedes aegypti and Aedes albopictus, including Zika, yellow fever and especially dengue and chikungunya, represent a growing public health concern in Africa. Insecticide-based strategies remain essential for the prevention and control of arboviral outbreaks. However, insecticide resistance in Ae. aegypti is globally widespread and appears to be rising in sub-Saharan Africa. Here, we reviewed the distribution and phenotypic and molecular evidence of insecticide resistance in Ae. aegypti across sub-Saharan Africa and summarized the underlying resistance mechanisms and key knowledge gaps. Bibliographic databases were searched for studies published between January 2010 and December 2023. The review identified 40 studies from 18 of 47 countries in sub-Saharan Africa. Among adults mosquitoes, resistance to dichlorodiphenyltrichloroethane (DDT) and pyrethroids was reported in multiple studies across West and Central Africa, while resistance to carbamates was also documented in several countries, comparatively fewer studies reported resistance to organophosphates. For larvae 7 of 40 studies assessed susceptibility to temephos, with potential resistance reported in only one study. Molecular investigations identified five kdr mutations including F1534C, V1016I, V410L, V1016G and S989P in 12 countries while metabolic resistance involving cytochrome P450s, carboxylesterases, glutathione S-transferases and other detoxification enzymes was reported in a smaller number of studies and countries. Overall, the evidence base remains geographically uneven and limited for several insecticide classes and resistance mechanisms. This review highlights important knowledge gaps, including the limited assessment of larvicides, emerging adulticide options, resistance intensity and Aedes-targeted vector control interventions, and underscores the need for more systematic and standardized insecticide resistance surveillance across sub-Saharan Africa. - Source: PubMed
Publication date: 2026/09/30
Maiga Abdoul-Aziz MMedjigbodo Adandé AToé Hyacinthe KSombié AboubacarFotso-Toguem Yvan GDjogbenou Luc SWeetman DavidBadolo Athanase - Upfront molecular diagnostics are used to characterize genetic features of colorectal cancer, guiding therapy. Since colorectal cancer is usually surgically resected, these samples are used for such characterizations. The extent to which liver metastases maintain the genetic profile of the primary tumor is a key question. - Source: PubMed
Publication date: 2026/09/15
Rásó ErzsebetBarbai TamasVizkeleti LauraUhlyarik AndreaTímár József - Cutaneous angiosarcoma (cAS) is an aggressive vascular malignancy comprising idiopathic primary cutaneous angiosarcoma (PCAS) and secondary cutaneous angiosarcoma (SCAS) arising after radiation therapy or chronic lymphedema. Comparative genomic analyses delineating these subtypes in Asian populations remain limited. We retrospectively evaluated 15 Japanese cAS patients (10 PCAS, 5 SCAS) who underwent comprehensive genomic profiling (CGP) using FoundationOne CDx or liquid CDx between 2020 and 2026. Variants of unknown significance (VUS) and potential clonal hematopoiesis (CH)-derived mutations were systematically excluded. The cohort demonstrated a uniformly low tumor mutational burden (median 4 mut/Mb) with no MSI-H cases. TP53 was the most frequent driver mutation (47%), followed by CDKN2A (33%), MYC (33%), KDR (27%), CDKN2B (27%), MTAP (27%), KIT (27%), and PDGFRA (27%). A molecular separation was observed between the two clinical subtypes, where focal MYC amplification was confined to SCAS cases (5/5, 100%), whereas PCAS lesions were enriched with cell-cycle pathway alterations via co-deletions of CDKN2A, CDKN2B, and MTAP, alongside variable receptor tyrosine kinase (RTK) gains (KIT/PDGFRA). RAS pathway mutations presented only as three cases of missense variants across both subtypes. Although limited by sample size, these findings suggest subtype-associated genomic patterns in Japanese cAS and may serve as preliminary observations that warrant validation in larger East Asian cohorts. - Source: PubMed
Publication date: 2026/09/29
Liu Wei-TingSeshimo HarutakaInoue TatsutoKurisaki MichitoshiMiyazaki RikakoKase MisakiKage YutaNakano EijiNamikawa Kenjiro - Insecticide resistance profiles and underlying mechanisms are essential for developing effective and sustainable vector control strategies. This study aimed to investigate the insecticide susceptibility profiles and kdr genotypes in field populations of Aedes aegypti and Ae. albopictus. Bioassays were conducted on six Ae. albopictus and two Ae. aegypti populations towards deltamethrin, lambda-cyhalothrin, pirimiphos-methyl, and bendiocarb. Piperonyl butoxide (PBO) synergism and kdr genotyping of the Vssc gene were conducted. Against pyrethroids, Ae. aegypti and four out of six Ae. albopictus populations exhibited resistance. PBO restored full susceptibility across Ae. albopictus populations but not against Ae. aegypti, suggesting metabolic resistance involving cytochrome P450 monooxygenese. All tested mosquitoes were susceptible to pirimiphos-methyl. F1534C and V1016G kdr mutations were detected in both populations of Ae. aegypti. For the F1534C locus, the resistant allele Cys1534 was predominant but population specific. At codon 1016, Gly1016 was present but less frequent than Val1016, with resistant homozygotes population specific. These findings highlight heterogeneous resistance profiles across provinces and species, underscoring the need for vector and location-specific vector control strategies. PBO synergist addition remains viable option for managing Ae. albopictus resistance but pyrethroid alternatives such as pirimiphos-methyl and bendiocarb offer an interspecies option for controlling Aedes vectors. - Source: PubMed
Publication date: 2026/09/29
Ahebwa AlexWu Yao-YuNararak JirodNeoh Kok-BoonChareonviriyaphap Theeraphap - Vascular endothelial cells express abundant sialylated glycans, but their function remains unclear. To determine the role of endothelial overall sialylation, which is controlled by , in adult mice. We generated mice with inducible deletion of in endothelial cells (iEHC ) using tamoxifen-inducible . Induced deletion of in adulthood caused progressive weight loss, anemia, and spontaneous intestinal bleeding. Adult intestinal villus capillaries exhibited disorganized networks, loss of vascular integrity, and bleeding. Multiplexed Error-Robust Fluorescence in Situ Hybridization spatial transcriptomic analysis revealed downregulation of endothelial genes essential for angiogenesis and endothelial specialization, including , , and . Immunostaining confirmed loss of VEGFR2, disorganized VE-cadherin junctions, and impaired PLVAP-dependent capillary fenestration. Endothelial deletion also reduced endothelial von Willebrand factor expression and plasma multimerization, indicating impaired hemostatic function. Our results reveal new roles for -dependent endothelial sialylation in maintaining the fate and integrity of the intestinal microvascular network in adult mice. - Source: PubMed
Publication date: 2026/09/29
Jiang YizhiRathore ShipraGeng XinKirby NicoleIto ChihiroMcDaniel J MichaelZhou MeixiangMcGee SamuelSrinivasan R SathishXia Lijun