Anti-Mouse Notch1 PE 25 ug
- Known as:
- Antibody toMouse Notch1 PE 25 ug
- Catalog number:
- 12-5765-80
- Category:
- -
- Supplier:
- eBioscience
- Gene target:
- Anti-Mouse Notch1 25
Related genes to: Anti-Mouse Notch1 PE 25 ug
- Gene:
- NOTCH1 NIH gene
- Name:
- notch receptor 1
- Previous symbol:
- TAN1
- Synonyms:
- -
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1992-02-13
- Date modifiied:
- 2019-04-23
Related products to: Anti-Mouse Notch1 PE 25 ug
Related articles to: Anti-Mouse Notch1 PE 25 ug
- Breast cancer is characterized by uncontrolled breast cell growth and eventual tumor formation. It is crucial to explore the molecular mechanisms of NK cell function in the breast cancer microenvironment. - Source: PubMed
Publication date: 2026/09/07
Wang LingyingBie TianminHe JiongmingXiao YujieChen Kang - Calcific aortic valve disease (CAVD) is a degenerative cardiovascular disorder characterized by progressive valvular thickening and calcification, ultimately leading to aortic stenosis, heart failure, and high mortality. Despite associations with hyperlipidemia, inflammation, and bicuspid aortic valve (BAV) malformation, no targeted pharmacotherapies exist, indicating unaddressed core pathogenic mechanisms. The aortic valve is composed of valvular interstitial cells (VICs) and endothelial cells (VECs) which are constantly exposed to hemodynamic forces, with progressive extracellular matrix (ECM) stiffening during CAVD-two mechanobiological pillars closely linked to pathogenesis. This article synthesizes current mechanobiology research on CAVD and bridges biomechanical insights with clinical practice to dissect precision interventions. Clinical and experimental evidence confirms abnormal hemodynamics (e.g., oscillatory shear stress, elevated blood pressure) and increased ECM stiffness drive CAVD by modulating VIC phenotypic transition (osteogenic differentiation, myofibroblastic transformation), VEC dysfunction (epithelial-mesenchymal transition, inflammation), and ECM remodeling/apoptosis. These effects are mediated by chemical pathways (Transforming growth factor-β1(TGF-β1), YAP, Notch1/Runt-related transcription factor 2 (Runx2), Wnt/β-catenin) and cytoskeleton/nucleoskeleton-dependent mechanotransduction (integrin-linker of the nucleoskeleton and cytoskeleton (LINC) complex-chromatin cascade). Current research uses bioreactors and stiffness-tunable gels but faces challenges of unstandardized parameters, decoupled mechanical cues, and limited clinical specimens. Derived insights enable mechanomedicine innovations: novel drug targets, physical therapies (ultrasound/light-mediated ECM modulation), personalized surgical planning (computational fluid dynamics-guided valvuloplasty), optimized bioprosthetic valves, and early diagnosis (valvular elastography). Overcoming interdisciplinary barriers and standardizing methods will accelerate translation of mechanobiological findings into precision clinical strategies, addressing CAVD patients' unmet needs. - Source: PubMed
Publication date: 2026/08/22
Jiang YefanHe YuqiuJia QiongChen SiTan YouhuaShao Yongfeng - Excessive iron may adversely affect intestinal health, particularly the immature intestine of infants. The mechanism of high iron intake affecting intestine in infants remains unclear. - Source: PubMed
Publication date: 2026/09/05
Qiu LiliXiong WeiHu MengxiaoZhou JunLv CongZhang WeiboWang Xiaoyu - To clarify the core regulatory role and molecular mechanism of farnesoid X receptor (FXR) in the progression from liver inflammation/fibrosis to hepatocellular carcinoma (HCC), and to provide a theoretical basis for targeted prevention and treatment of liver diseases. - Source: PubMed
Publication date: 2026/08/26
Qiuluo ChengGuiqun HuangXue HanYing Zhu - Huan Le Ning Decoction is a traditional Chinese medicinal formula empirically used to alleviate perimenopausal emotional disturbances. Despite its clinical application, the neurobiological mechanisms remain unclear. - Source: PubMed
Publication date: 2026/09/05
Ma XianXu YujieBi YuYang LuLi YixuanSun YilinZhao LinShao YanfeiZhang Qin