Anti-Human CD94 PE 100 tests
- Known as:
- Antibody toHuman CD94 PE 100 tests
- Catalog number:
- 12-0949-42
- Category:
- -
- Supplier:
- eBioscience
- Gene target:
- Anti-Human CD94 100 tests
Related genes to: Anti-Human CD94 PE 100 tests
- Gene:
- KLRD1 NIH gene
- Name:
- killer cell lectin like receptor D1
- Previous symbol:
- CD94
- Synonyms:
- -
- Chromosome:
- 12p13
- Locus Type:
- gene with protein product
- Date approved:
- 1998-01-16
- Date modifiied:
- 2016-01-14
Related products to: Anti-Human CD94 PE 100 tests
Related articles to: Anti-Human CD94 PE 100 tests
- The mouse estrous cycle drives cyclical remodelling of the endometrium, essential for uterine function and embryo implantation. However, the molecular mechanisms orchestrating these dynamic changes remain incompletely defined. In this study, we preliminarily staged C57BL/6 mice using vaginal smear cytology and confirmed phase-dependent morphological changes, including cyclical endometrial thickening and glandular remodelling, via histological assessment. To elucidate the underlying molecular landscape, we performed comprehensive RNA sequencing of the mouse endometrium across four distinct phases: proestrus, estrus, metestrus and diestrus. To ensure analytical rigour and identify core regulatory factors, we integrated three synergistic computational approaches: WGCNA to identify phase-specific co-expression modules, MFUZZ to characterize dynamic temporal expression trajectories, and DESeq2 to pinpoint significantly differentially expressed genes (DEGs). Functional enrichment analysis revealed that these phase-specific signatures are predominantly involved in the cell cycle, extracellular matrix organization, oxidative phosphorylation and DNA replication. Notably, we identified several high-connectivity hub genes and pathways, including Natural Killer (NK) cell-mediated cytotoxicity (Cd244a, Klra4, Klrd1), Oestrogen signalling (Ccnd1, Akt1, Prkaca) and Wnt signalling components (Cdh1, Skp1a, Pax2). Transcription factors such as Sox4 and Lef1, along with the cell cycle regulator Cks1b, exhibited phase-consistent expression patterns aligned with endometrial proliferation and preparation for implantation. Our findings delineate a complex hub-gene regulatory network coordinating cyclic endometrial regeneration. This study provides a comprehensive transcriptomic atlas of the murine endometrium, offering novel insights into uterine biology with significant implications for understanding reproductive health and uterine diseases. - Source: PubMed
Wang XinyanXu KeyiLi BintingXu XiaotongLu GangWang LePan RuolangZhang Ting - CD1d-restricted invariant natural killer (iNK) T cells are innate T cells known for their ability to shape adaptive immunity toward inflammation or immune-suppression via the rapid production of Th1-, Th2-, and Th17-type cytokines from corresponding iNKT subsets such as NKT1, NKT2, and NKT17. IL-10-producing invariant NKT cells, termed NKT10 cells, are thought to play an immunoregulatory role, but their potential clinical use remains underexplored. We characterized human NKT10 cells from cord-derived iNKT cells and investigated their therapeutic utility in allogeneic stem cell transplantation. Cord and cord-derived iNKT cells contained a high frequency of CD4CD25CD161FoxP3 iNKT cells and showed Th2/Th10-biased cytokine production upon antigenic stimulation. Accordingly, cord-derived iNKT cells displayed a distinct gene expression profile with upregulated genes related to NKT2, NKT10, and regulatory T cells compared with adult donor-derived iNKT cells. Furthermore, single-cell RNA sequencing analysis of cord-derived iNKT cells confirmed the presence of NKT10-like subset that was enriched with multiple immunoregulatory pathways and genes related to immune-checkpoints (, , , and ) and NKT10 (, , and ), whereas the NKT1/17-like subset present in adult donor-derived iNKT cells showed upregulation of genes related to cytotoxicity (, , and ), NKR (, , , and ), NKT1 ( and ), and NKT17 (). Lastly, cord-derived iNKT cells suppressed alloreactive T cell proliferation and ameliorated xenogeneic graft-versus-host disease where the immunodeficient NSG mice received human peripheral blood mononuclear cells supplemented with cord-derived iNKT cells. Thus, NKT10-enriched, cord-derived iNKT cells are candidate cell therapeutics for immune-modulation in allogeneic stem cell transplantation and other autoimmune diseases. - Source: PubMed
Publication date: 2026/06/10
Trujillo-Ocampo AbelBorges PamellaGrefe MaisonVaz de Freitas MartielaLee Sung-EunQi YuanClinton JelitaLi DanHe HongYu LingPeris-Cuesta ArnauEhli Erik AMa QingSu XiaopingAmaral Antunes DinlerAl-Atrash GheathMolldrem Jeffrey JShpall Elizabeth JIm Jin S - TB meningitis (TBM) has up to 50% mortality in people living with HIV. We investigated differences in cerebrospinal fluid (CSF) host immune responses associated with short-term mortality. - Source: PubMed
Publication date: 2026/06/18
Louine MartineauDandekar RaviReddy Sumanth PKaralius Mary CWaldrop GreerWang ShiyinGakuru JaneKimuda SarahMugabi TimothyMusubire Abdu KKagimu EnockAbassi MahsaKabahubya MableWilliams Darlisha APhan Hoang VanDai BiyueZia MahamZorn Kelsey CFouassier CamilleGerungan ChloeMarra Pedro SSkipper Caleb PBahr Nathan CLangelier Charles RCreswell Fiona VBoulware David RMeya David BWilson Michael R - Membranous nephropathy (MN) is an autoimmune disease characterized by immune complex deposition and progressive renal function impairment. Although studies have demonstrated that dysregulation of adaptive immunity, primarily T lymphocyte dysregulation, plays a significant role in its pathogenesis through heterogeneity, the understanding of immune cell subpopulations and key immune response genes during the pathological process of MN remains incomplete. - Source: PubMed
Publication date: 2026/06/17
Li YaoWang YaoyaoHou YanjiaoZheng QingZhang WeiYang Xiancong - Breast cancer is the most prevalent malignancy in women, and the limited effectiveness of current treatments highlights the need for novel immune regulatory mechanisms to improve long-term survival. This study investigated the role of Vim in PGI synthesis and its impact on tumor immune regulation. Multiomics profiling revealed molecular alterations following Vim deletion, which were validated in murine breast cancer models using RT-qPCR, Western blot, ELISA, and flow cytometry, with rescue experiments involving exogenous PGI. The findings showed that Vim deletion downregulated arachidonic acid metabolism, reduced PTGIS expression, and significantly lowered PGI levels. Functional assays demonstrated that Vim deficiency enhanced T cell-mediated antitumor immunity, evidenced by an increased proportion of CD8 T cells, upregulation of cytotoxic genes (, , , and ), and activation of inflammation-related signaling pathways, as indicated by enhanced phosphorylation of ERK1/2 and p65. Both exogenous PGI supplementation and ozagrel treatment reversed these effects. In conclusion, the Vim-PGI axis is identified as a key regulator of CD8 T cell immunity in breast cancer, representing a potential therapeutic target and a critical consideration in anticoagulant management during cancer immunotherapy. - Source: PubMed
Publication date: 2026/04/28
Quan HongShao LujingLi QiDong Chunyan