Anti-Human CD74 PE 100 tests
- Known as:
- Antibody toHuman CD74 PE 100 tests
- Catalog number:
- 12-0748-42
- Category:
- -
- Supplier:
- eBioscience
- Gene target:
- Anti-Human CD74 100 tests
Related genes to: Anti-Human CD74 PE 100 tests
- Gene:
- CD74 NIH gene
- Name:
- CD74 molecule
- Previous symbol:
- DHLAG
- Synonyms:
- -
- Chromosome:
- 5q33.1
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-10-05
Related products to: Anti-Human CD74 PE 100 tests
Related articles to: Anti-Human CD74 PE 100 tests
- Parasite-derived homologs of the cytokine macrophage migration inhibitory factor (MIF) function as virulent factors during parasitic infection. Recent evidence suggests MIF-like products from multicellular species can be targeted to ameliorate parasite burden. Here, we identify a broad contingent of hypothetical MIF-like proteins from genomic repositories and perform structure analysis to validate conserved homology. Further, we employ a diverse subset of MIF-specific assays to establish cross-species functionality of MIF proteins, including native enzymatic activity, binding to cognate receptor CD74, direct interactions with human MIF, and signaling through chemokine receptors CXCR2 and CXCR4. We demonstrate that MIF-like proteins retain a preserved architecture but are capable of diverse physiological outcomes due to small changes in key components of the conserved MIF structure. This work simultaneously provides a mechanistic understanding of virulence upon infection, while broadly examining the potential to neutralize MIF-like proteins for protection against various pathological species. - Source: PubMed
Publication date: 2026/06/26
Orkwis Jacob AManjula RamuLolis Elias J - PCLAF (PCNA clamp-associated factor) is a protein involved in DNA replication and DNA repair. Aberrant PCLAF expression has been reported in multiple malignancies and is associated with tumor progression and poor clinical outcomes. However, the biological role of PCLAF in hepatocellular carcinoma (HCC) remains incompletely understood, particularly with respect to its relationship with the tumor immune microenvironment. Therefore, this study aimed to systematically investigate the clinical significance, biological functions, and therapeutic potential of PCLAF in HCC through integrated multi-omics analyses, experimental validation, and drug screening approaches. - Source: PubMed
Publication date: 2026/07/22
Shu FeihongChen YidanYang XiaorongGou GuoyouLi GuonianYu JieWang FangLiu YoujiaDu QianXu JingyuXie Rui - Astrocytes act as crucial cellular centres of cholesterol synthesis and metabolism and help maintain homeostasis in the healthy CNS. Spinal cord injury (SCI) results in abnormalities in astrocytic cholesterol metabolism and excessive oxysterol accumulation, contributing to the activation of inflammation. However, the relevant regulatory mechanism involved in aberrant cholesterol metabolism by astrocytes has not been fully elucidated. In the present study, we demonstrated that SCI-induced D-DT protein levels increased synchronously with CH25H expression. Administration of the D-DT inhibitor 4-CPPC markedly decreased CH25H expression in astrocytes following SCI. D-DT facilitates CH25H production in astrocytes by activating the intracellular ERK/NF-κB pathway through binding to the CD74 receptor. Conditioned culture medium from astrocytes following the knockdown of astrocyte CH25H expression by siRNA reduced microglial migration. The inhibition of D-DT or CH25H activity reduces microglia/macrophage accumulation at the lesion site and improves motor functional recovery following SCI. Our results reveal a novel function of D-DT-mediated astrocytic CH25H activation, which modulates pathological microenvironments through the activation of inflammation. These data may provide a potential therapeutic strategy for CNS inflammation-associated diseases. - Source: PubMed
Publication date: 2026/07/21
Ji HuiyuanLi HuiZhu DongyanWang LiangCao YuejiaoZhai JiajiaXu DehuiHe BingqiangChen Weiguan - Peripheral neuropathy is a global health concern that markedly impairs quality of life. Peripheral nerve injury triggers complex interactions between the immune and nervous systems, driving persistent neuroinflammation and neuropathic pain. Macrophage migration inhibitory factor (MIF), a proinflammatory cytokine, has emerged as a key mediator in this process. Macrophage migration inhibitory factor binds to its primary receptor CD74, promotes cytokine release, recruits macrophages into the inflammatory milieu, and amplifies inflammatory responses. ISO-1, a small-molecule, high-affinity MIF inhibitor, targets the tautomerase active site of MIF, disrupts MIF-receptor (including canonical receptor CD74) binding, and thereby mitigates downstream inflammatory response. In this study, we investigated the anti-inflammatory and analgesic effects of ISO-1 in both male and female mice subjected to chronic constriction injury (CCI) of the sciatic nerve. A battery of behavioral, electrophysiological, immunohistochemical, and molecular approaches was used to evaluate the impact of systemic ISO-1 treatment on neuroinflammation and neuropathic pain. Electrophysiological recordings from the superficial dorsal horn neurons in acute spinal cord slices revealed that ISO-1 largely prevented the CCI-induced imbalance between excitatory and inhibitory postsynaptic currents. ISO-1 significantly reduced macrophage infiltration at the sciatic nerve injury site and within dorsal root ganglia. Notably, ISO-1 alleviated mechanical allodynia and thermal hyperalgesia in male mice, but not in female mice, a sex-specific effect corroborated by quantitative PCR analysis of inflammatory mediators. Together, these findings identify ISO-1 as a promising MIF-targeted strategy to counteract neuroinflammation and neuropathic pain after peripheral nerve injury and highlight the importance of sex-specific responses for the development of personalized immunomodulatory therapies. - Source: PubMed
Publication date: 2026/07/21
Pontearso MonicaBhattacharyya AnirbanAdamek PavelVasconcelos DanielSlepicka JakubHeles MarioSpicarova DianaPalecek Jiri - Cholangiocarcinoma (CCA) has a complex tumor microenvironment (TME) and poor immunotherapy response. Understanding how the adaptive immune response (AIR) affects the TME and prognosis is critical. - Source: PubMed
Publication date: 2026/07/06
Jie WangJixiang ZhouYang BaoYanting WangLing Liu