Anti-Canine CD44 FITC 100 tests
- Known as:
- Antibody toCanine CD44 fluorecein 100 tests
- Catalog number:
- 11-5440-42
- Category:
- -
- Supplier:
- eBioscience
- Gene target:
- Anti-Canine CD44 FITC 100 tests
Related genes to: Anti-Canine CD44 FITC 100 tests
- Gene:
- CD44 NIH gene
- Name:
- CD44 molecule (Indian blood group)
- Previous symbol:
- MIC4, MDU2, MDU3
- Synonyms:
- IN, MC56, Pgp1, CD44R, HCELL, CSPG8
- Chromosome:
- 11p13
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2019-04-23
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- Enteric nervous system development relies on migration, proliferation and differentiation of enteric neural crest-derived cells (ENCDCs), processes that are regulated by mesenchymal morphogens and the extracellular matrix (ECM). Hirschsprung disease (HD) is a congenital neurocristopathy in which abnormal gut motility results from loss of ENCDC-derived enteric ganglia in the colorectum. While enteric neural stem cell transplantation is a proposed therapy, current efforts are limited by poor cell migration in HD models. To address this, we investigated ECM-derived inhibitory cues on enteric neural stem cell transplantation efficiency. Immunohistochemistry of embryonic chick hindgut reveals dynamic chondroitin sulfate proteoglycan (CSPG) expression during development. In vitro assays show that CSPGs inhibit ENCDC migration, an effect reversed by chondroitinase ABC. Transplantation of enteric neurospheres into chick and mouse colon results in limited engraftment, but chondroitinase ABC significantly enhances migration of transplanted cells. Single-cell RNA sequencing of postnatal mouse neurospheres reveals high expression of CD44, a transmembrane glycoprotein that can act as a functional CSPG on the cell surface. Blocking CD44 function promotes neurosphere-derived ENCDC migration. Modulating inhibitory ECM components may enhance the success of regenerative therapies for HD. - Source: PubMed
Publication date: 2026/08/25
Szőcs EmőkeMueller Jessica LJurenka CsengeTóth Réka BorbálaHalasy ViktóriaHotta RyoSoós ÁdámGoldstein Allan MNagy Nándor - Magnetodynamic therapy (MDT), which utilizes the mechanical motion of magnetic nanoparticles (MNPs) under low-frequency magnetic fields (LFMFs), has emerged as a promising approach to overcome the major limitations of traditional chemotherapy. This study aims to evaluate an integrated therapeutic strategy, termed chemo-MDT, under in vitro conditions. - Source: PubMed
Publication date: 2026/08/19
Sarkhosh NafisehKandi Mohammad RezaMahna AkramSalehi Roya - Extramammary Paget's disease (EMPD) is a rare intraepithelial adenocarcinoma that arises predominantly in apocrine gland-rich areas. Its clinical presentation is non-specific, frequently leading to erroneous clinical diagnoses, diagnostic delay, and prolonged morbidity. A 77-year-old female presented with a 10-year history of a dermatosis affecting the trunk, external genitalia, and the inner side of the right thigh, characterized by three erythematous-squamous plaques (1 to 4 cm in diameter). The patient had a previous histopathological diagnosis of squamous cell carcinoma in situ and was treated with topical 5% 5-fluorouracil for six months. Due to recalcitrance to therapy, a new incisional biopsy was performed on the thigh lesion. Histopathology revealed large, pleomorphic cells with clear cytoplasm and pagetoid migration. Immunohistochemistry showed positivity for CK7 and negativity for CD44, supporting the diagnosis of EMPD. The patient was subsequently referred for Mohs micrographic surgery. Taking new biopsies for recalcitrant lesions is critical. An appropriately selected, broad immunohistochemical panel is a fundamental tool to differentiate intraepidermal malignancies in complex anogenital cases. - Source: PubMed
Publication date: 2026/07/25
Estrada Marentes PatricioCortés López Paulina NArenas RobertoVega-Memije Elisa - Rare lung neuroendocrine neoplasms (LNENs), including pulmonary carcinoids and large-cell neuroendocrine carcinomas (LCNEC), are heterogeneous tumors. Current World Health Organization (WHO) classification primarily relies on morphological features, leading to important inter-observer variability and sub-optimal prognostic accuracy. This review highlights the clinical utility of molecular profiling to overcome these diagnostic and prognostic challenges. Recent multi-omics studies have demonstrated that pulmonary carcinoids are not a uniform entity but comprise distinct molecular subgroups (A1, A2, B, and supra-carcinoids) with unique clinical and genomic features. Furthermore, the recently described atypical SCLC adds another layer of heterogeneity to this spectrum. For clinical practice, a biomarker panel consisting of OTP, CD44, and Ki-67 can improve the prediction of disease recurrence in pulmonary carcinoids, enabling personalized follow-up strategies. Furthermore, subgroup-specific markers, such as OTP, ASCL1, and HNF1A, may facilitate clinical implementation of molecular profiles. Within LCNEC molecular profiles are heterogenous, generally defining two major subgroups (SCLC-like and NSCLC-like). Emerging therapies targeting and show potential relevance for clinical screening of these targets. Integration of subgroup-specific molecular markers into routine diagnostics is essential. This approach may allow clinicians to refine risk stratification, prevent unnecessary long-term surveillance, and develop personalized treatment approaches for patients with pulmonary NENs. - Source: PubMed
Publication date: 2026/08/10
Leunissen DaphneMoonen Lauravan Weert TijmenHeijboer FrankHillen Lisa MVon der Thüsen JanSpeel Ernst-JanDingemans Anne-MarieDerks Jules Louis - Posttranslational modification (PTM) plays an important role in protein regulation and may influence tumor initiation and progression. However, the role of PTM-related programs in lung adenocarcinoma (LUAD) remains incompletely understood. - Source: PubMed
Publication date: 2026/08/24
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