Anti-Mouse CD127 FITC 50 ug
- Known as:
- Antibody toMouse CD127 fluorecein 50 ug
- Catalog number:
- 11-1271-81
- Category:
- -
- Supplier:
- eBioscience
- Gene target:
- Anti-Mouse CD127 FITC 50
Related genes to: Anti-Mouse CD127 FITC 50 ug
- Gene:
- IL7R NIH gene
- Name:
- interleukin 7 receptor
- Previous symbol:
- -
- Synonyms:
- CD127, IL7RA
- Chromosome:
- 5p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-07
- Date modifiied:
- 2019-04-23
Related products to: Anti-Mouse CD127 FITC 50 ug
Related articles to: Anti-Mouse CD127 FITC 50 ug
- Tools that enable functional inhibition of the long-term effects of immunological signalling cascades remain challenging to develop, in part because biological outcomes often arise long after the initiating receptor-ligand interaction and lack accessible experimental readouts. Interleukin-7 (IL-7) cytokine signalling through the IL-7 receptor (IL-7R) exemplifies this problem, as IL-7-mediated survival signals in activated CD4+ T cells emerge over extended timescales, yet play a critical role in human disease. Here, we describe the development of engineered Adhiron binders as molecular tools to inhibit IL-7/IL-7R signalling. Using phage display against glycosylated human IL-7Rα ectodomains, we isolated 23 unique Adhiron binders. From this panel, we identified a lead binder, Adh-42, that binds both soluble and membrane-associated IL-7Rα. Adh-42 inhibited proximal IL-7R signalling events in human cells and abrogated IL-7-mediated rescue from activation-induced cell death in human primary CD4+ T-cell blasts (using a recently developed in vitro assay). Together, these findings demonstrate that Adhiron binders can be used to target a cell-surface cytokine receptor (IL-7R) and selectively inhibit downstream biological outcomes in human primary cells. This work establishes Adhirons as versatile molecular tools for probing IL-7 cytokine signalling and provides a framework to support the design and evaluation of future therapeutic strategies. - Source: PubMed
Publication date: 2026/09/18
Perez-Witzke DanielTiede ChristianLou MinGuillet MaximeParmar RekhaRobinson James IPonchel Frederique - Insomnia is a prevalent sleep disorder that strongly affects one's quality of life and physical well-being. Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the intestines, and a majority of IBD patients suffer from comorbid insomnia. However, the shared molecular features linking insomnia and IBD remain poorly characterized. - Source: PubMed
Publication date: 2026/09/01
Guo HanXu XudongShi HuanyingCui MengZhang MinWang HongdanZhang YunxuanZhou HaifengSun XuLiu Xiaoyan - Cirrhosis-associated immune dysfunction (CAID) contributes to poor outcomes after liver transplantation (LT), but pre-transplant immune predictors remain insufficiently defined. We investigated whether pre-transplant whole blood transcriptomic profiling was associated with post-LT outcomes in this exploratory ancillary study of the prospective EDMONHG cohort. Transcriptomic analysis of 26 immune-related genes was performed on 97 LT recipients. PCA and volcano plots identified candidate biomarkers; associations with outcomes were assessed using ROC analyses and Kaplan-Meier estimates with cohort medians as thresholds. PC1 (43.5% of variance) decreased progressively from cACLD to ALF (p < 0.001) and was lower in post-LT infected patients (p = 0.044). Within the first month, 34 patients (35%) developed infections; 7 (7.2%) died within 1 year. Three genes met predefined exploratory criteria (q < 0.10, AUC > 0.65) for infections: GNLY and IL7R were downregulated and IL10 upregulated. Low GNLY or high IL10 expression was associated with reduced 30-day infection-free survival (p = 0.019 and p = 0.013). CIITA, IL10, CD177 and S100A9 showed associations with one-year survival, though results should be treated as exploratory given the limited number of events. Pre-transplant transcriptomics captures CAID severity and identifies candidate gene signatures associated with post-LT outcomes. These hypothesis-generating findings warrant validation in larger multicenter cohorts. - Source: PubMed
Publication date: 2026/08/28
Delignette Marie-CharlottePeronnet EstelleRiff ArnaudAntonini TeresaBodinier MaximeCerrato ElisabethPantel SolèneCoz ElsaMuller XavierRossignol GuillaumeMabrut Jean-YvesDumortier JérômeGuichon CélineBlet AliceAubrun FredericMonneret GuillaumeLebossé Fanny - AAA ATPase p97 is a central regulator of protein homeostasis, yet its role in late-stage thymocyte development remains undefined. Here, we demonstrate that T-cell-specific ablation of p97 in mice severely blocks the double-positive (DP) to single-positive (SP) transition, with a pronounced defect in CD8 lineage commitment. Using both genetic deletion and acute pharmacological inhibition, we revealed a stage- and lineage-specific requirement for p97, with DP thymocytes being most sensitive to p97 loss. This failure in late-stage positive selection leads to intrathymic developmental arrest of immature DP cells and profound peripheral T-cell lymphopenia. Mechanistically, p97 deficiency results in the accumulation of ubiquitinated proteins, triggering the unfolded protein response and apoptosis in thymocytes. Furthermore, we identified a critical requirement for p97 in sustaining IL-7 receptor (IL-7R) expression and JAK signaling. Strikingly, pharmacological activation of JAK partially rescued SP thymocyte development in p97-deficient mice. Our findings establish p97-mediated protein homeostasis as a previously uncharacterized, cell-intrinsic checkpoint that is indispensable for late-stage positive selection by preventing proteostatic collapse and ensuring the fidelity of IL-7R signaling. - Source: PubMed
Publication date: 2026/09/07
Yu RuixianZhang WeihongHan YiWang WenjiaMeng YanNie PingpingZhang CuiweiYe ZaishengYan BinZhou ZhaocaiJiao Shi - Intrauterine growth restriction (IUGR) is a leading cause of maternal and neonatal morbidity and mortality, particularly in low- and middle-income countries. Placental transcriptomics data were analysed to mapped dysregulated pathways via STRING-based PPI networks, identifying hubs and validating pesticide targets by molecular simulations. Rank-based prioritization identified IL7R, LCK and ZAP70 as top hub proteins driving placental dysfunction with cypermethrin exhibiting the lowest binding affinities across them (docking scores: -7.7, -8.7, -9.3 kcal/mol, respectively). Molecular dynamics simulations confirmed the stability of these docked complexes, while toxicity profiling indicated genotoxic potential for permethrin and high aquatic toxicity for deltamethrin. Thus, we show the critical molecular mediators linking pyrethroid exposure to IUGR, suggesting further experimental validation to support maternal health risk assessment. - Source: PubMed
Publication date: 2026/06/30
Shukla Adarsh KumarTyagi Anuj KumarKumar Sandeep