Anti-Mouse CD69 FITC 500 ug
- Known as:
- Antibody toMouse CD69 fluorecein 500 ug
- Catalog number:
- 11-0691-85
- Category:
- -
- Supplier:
- eBioscience
- Gene target:
- Anti-Mouse CD69 FITC 500
Related genes to: Anti-Mouse CD69 FITC 500 ug
- Gene:
- CD69 NIH gene
- Name:
- CD69 molecule
- Previous symbol:
- -
- Synonyms:
- CLEC2C
- Chromosome:
- 12p13.31
- Locus Type:
- gene with protein product
- Date approved:
- 1992-08-06
- Date modifiied:
- 2016-10-05
Related products to: Anti-Mouse CD69 FITC 500 ug
Related articles to: Anti-Mouse CD69 FITC 500 ug
- During pregnancy, immune tolerance toward the semi-allogeneic fetus must be established. γδT cells constitute a distinct T-cell lineage characterized by expression of the γδT-cell receptor (γδTCR). They combine rapid innate-like responses with adaptive immune functions and contribute to feto-maternal immune regulation; however, their peripheral phenotypic characteristics, including chemokine receptor (ChR) profiles potentially relevant to decidual recruitment, remain incompletely characterized. Peripheral blood from healthy non-pregnant and first-trimester pregnant women was analyzed by flow cytometry to assess γδT-cell phenotypes and CCR5/CCR6 ChR expression. Analysis of γδT-cell subsets defined by lower (γδTCR) or higher (γδTCR) surface γδTCR expression showed that CCR5/CCR6 cells were more frequent in γδTCR cells, whereas CCR5 phenotypes were more prominent in γδTCR cells; CD4/CD8 and CD56/CD8 distributions were comparable. Resting γδT cells were mainly CD4/CD8, whereas recently activated CD69 γδT cells had increased CD4 or CD8 single-positive frequencies. Compared with non-γδT cells, γδT cells showed distinct CD4/CD8-linked CCR5/CCR6 organization, including a CCR5/CCR6 preference. Unlike non-γδT cells, conventional CD56 and NK-like CD56 γδT cells retained similar CCR5/CCR6 profiles across CD4/CD8-defined subsets. PMA/ionomycin-stimulated samples generally exhibited lower CCR5 and higher CCR5 frequencies across CD4 conventional and NK-like γδT cell subsets. Pregnancy-related circulating γδT-cell phenotype changes were negligible, possibly reflecting decidual immune adaptation. Overall, the study highlights γδTCR intensity-linked ChR heterogeneity and, in contrast to non-γδT cells, conserved CCR5/CCR6 organization across CD56-defined γδT-cell subsets. Broader ChR phenotyping and functional migration analyses could clarify the biological relevance of these subset-specific differences. - Source: PubMed
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