Anti-Human CD68 FITC 25 tests
- Known as:
- Antibody toHuman CD68 fluorecein 25 tests
- Catalog number:
- 11-0689-71
- Category:
- -
- Supplier:
- eBioscience
- Gene target:
- Anti-Human CD68 FITC 25 tests
Related genes to: Anti-Human CD68 FITC 25 tests
- Gene:
- CD68 NIH gene
- Name:
- CD68 molecule
- Previous symbol:
- -
- Synonyms:
- SCARD1, macrosialin, GP110, DKFZp686M18236, LAMP4
- Chromosome:
- 17p13.1
- Locus Type:
- gene with protein product
- Date approved:
- 1993-06-11
- Date modifiied:
- 2016-10-05
Related products to: Anti-Human CD68 FITC 25 tests
Related articles to: Anti-Human CD68 FITC 25 tests
- Idiopathic pulmonary arterial hypertension (IPAH) is driven by progressive vascular remodeling, particularly smooth muscle cell (SMC) proliferation. Current combination vasodilator therapies have markedly improved outcomes; however, prognosis remains poor in subgroups such as patients with respiratory comorbidities. Elevation of intravascular hydrostatic pressure is a hallmark of IPAH, yet its direct role in pulmonary artery SMCs remains unclear. We aimed to identify pressure-responsive mediators using a newly developed hydrostatic pressurization system to model hypertensive hemodynamics. - Source: PubMed
Publication date: 2026/09/09
Kogami MarikoKato YukoIto SatokoUchida KeikoInoue HanaHidaka YukoTanifuji ShotaYokotsuka MayumiYamamoto YoshinariNagao ToshitakaAbe ShinjiReddel Roger RNakamura KazufumiYokoyama Utako - Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial lung disease with limited therapeutic options. Existing hiPSC-derived lung organoid models are largely restricted to single epithelial lineages and cannot endogenously integrate multiple pulmonary cell types, limiting mechanistic studies and drug screening. - Source: PubMed
Publication date: 2026/08/25
Hua ChenfengQu ChaojieYang LiuZhao WenfeiZhao JunweiJia YongliangMa ChengjieShang PingpingLi XiangXie FuweiNie Cong - Erdheim-Chester disease (ECD) is an extremely rare non-Langerhans cell histiocytosis, a category of hematologic disorders characterized by the proliferation of foamy histiocytes. ECD predominantly affects adults, and pediatric cases with cerebral ventricular system involvement are exceptionally rare, with only a few previous reports. Moreover, epiphyseal involvement has not been characterized by magnetic resonance imaging (MRI) in children with ECD. Here we present a pediatric case of ECD involving both the cerebral ventricular system and epiphyses, highlighting diagnostic challenges and novel imaging findings relevant to pediatric hematologists. - Source: PubMed
Publication date: 2026/08/25
Yan JieLi JuLi QianHe XiaoZhu MingFan LupingLi RonghuiLong YanHuang Shuixian - Environmental degradation and accumulation of plastics results in micro- and nanoplastics that are small enough to cross biological barriers, including the blood-brain barrier. Microglia, resident immune cells of the brain, are critical regulators of neuroimmune homeostasis and represent a cellular target of nanoplastic exposure. In this study, we assessed the neurotoxic effects of two sizes of polystyrene nanoplastics (PS-NPs; 100 nm and 500 nm) using integrated in vivo and in vitro exposure and washout paradigms. In vivo exposure in mice (60 days; 1.5 mg/day) showed the presence of both PS-NPs sizes in the cerebral cortex without overt histopathological damage. However, cortical microglia showed pronounced morphological remodeling, assessed by Sholl and Skeleton analyses. Transcriptomic profiling of cortical tissue revealed a strong size-dependent response. The 100 nm PS-NPs group revealed 18 DEGs (|log₂FC= ≥ 2, padj < 0.05), whereas the 500 nm PS-NPs showed more than 4000 DEGs, including upregulation of immune- and microglia-associated genes (CCL5, CXCL10, LCN2, LYZ2) and downregulation of synaptic and neuronal signaling genes (GRIN2B, SYN1, STX1B, MAP1B, ITPR1/2). Using BV2 microglial cells, data indicate size dependent internalization of PS-NPs via the endolysosomal pathway. While both the 100 and 500 nm particles were present in late endosomes, only the 100 nm particles were found in lysosomes. Microglial activation markers (Iba1, CD68) exhibited a transient, size- and concentration-dependent increase, correlated with intracellular particle burden rather than cumulative exposure. Overall, these findings demonstrate that PS-NPs reached cortical regions of the brain, driving size-dependent microglial activation and transcriptomic reprogramming, even after cessation of exposure to PS-NPs. - Source: PubMed
Publication date: 2026/09/05
Tavakolpournegari AlirezaKannan UnnikrishnanGregory MaryDufresne JulieCostantino SantiagoLefrancois StephaneCyr Daniel G - Combination immunotherapy has shown encouraging activity across multiple solid tumors. We report the complete and consecutive cohort of patients with locally advanced oral squamous cell carcinoma (OSCC) treated at a single center within the prospective, multicenter, randomized phase 2 BelieveIT-201 trial (ASND0038), evaluating neoadjuvant intratumoral Toll-like receptor (TLR) 7/8 agonist (TransCon TLR7/8 Agonist) therapy combined with systemic immunotherapy. - Source: PubMed
Publication date: 2026/09/04
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