Anti-Rat CD8b FITC 50 ug
- Known as:
- Antibody toRat CD8b fluorecein 50 ug
- Catalog number:
- 11-0080-81
- Category:
- -
- Supplier:
- eBioscience
- Gene target:
- Anti-Rat CD8b FITC 50
Related genes to: Anti-Rat CD8b FITC 50 ug
- Gene:
- CD8B NIH gene
- Name:
- CD8b molecule
- Previous symbol:
- CD8B1
- Synonyms:
- -
- Chromosome:
- 2p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-04-13
- Date modifiied:
- 2016-10-05
Related products to: Anti-Rat CD8b FITC 50 ug
Alkaline Phosphatase Conjugated Affinity Purified anti-Swine IgG (H&L) [Goat] Secondary_Antibodiesα - Calcitonin Gene Related Peptide, α - CGRP, rat'F 4_80 Antigen (mouse) Host Rat'F 4_80 Antigen (mouse) Host Rat(2_Furoyl)_PAR_2 (2_6)_Orn amide (mouse, rat) Salt Trifluoroacetate Binding _ Synonym (2_Furoyl)_LIGRLOamide SumFormula C36H63N11O8(2_Furoyl)_PAR_2 (2_6)_Orn amide (mouse, rat) Salt Trifluoroacetate Binding _ Synonym (2_Furoyl)_LIGRLOamide SumFormula C36H63N11O8(Ala11·22·28)_VIP (human, bovine, porcine, rat) Salt Trifluoroacetate Binding _ Synonym (Ala11·22·28)_Aviptadil SumFormula C139H231N43O39S(Ala11·22·28)_VIP (human, bovine, porcine, rat) Salt Trifluoroacetate Binding _ Synonym (Ala11·22·28)_Aviptadil SumFormula C139H231N43O39S(Ala13)-Apelin-13 (human, bovine, mouse, rat) 98% C63H107N23O16S CAS: 568565-11-7(Ala13)_Apelin_13 (human, bovine, mouse, rat) Salt Trifluoroacetate Binding _ Synonym SumFormula C63H107N23O16S(Ala13)_Apelin_13 (human, bovine, mouse, rat) Salt Trifluoroacetate Binding _ Synonym SumFormula C63H107N23O16S(Ala96)-Myelin Basic Protein (87-99) (human, bovine, rat) 98% C70H110N20O17 CAS:(Ala96)_Myelin Basic Protein (87_99) (human, bovine, rat) Salt _ Binding _ Synonym SumFormula C72H112N20O17(Ala96)_Myelin Basic Protein (87_99) (human, bovine, rat) Salt _ Binding _ Synonym SumFormula C72H112N20O17(Arg6,b_cyclohexyl_Ala8,D_Tic16,Arg17,Cys18)_Atrial Natriuretic Factor (6_18) amide (mouse, rabbit, rat) Salt _ Binding (Disulfide_bond) Synonym A71915 SumFormula C69H116N26O15S2 Related articles to: Anti-Rat CD8b FITC 50 ug
- Cervical cancer (CC) is one of the leading malignancies impacting women worldwide, with a large number of cases occurring in developing countries. However, there is a need for optimal predictive models that can precisely forecast the prognosis and guide treatment selection. Programmed cell death (PCD) and immune responses (IRs) are pivotal in understanding disease progression, diagnosis, therapeutic decision-making, and risk stratification, making them promising prognostic markers. In this study, machine learning approaches were applied to identify key prognostic genes related to PCD and IR, which led to the development of three prognostic models: a PCD index, an IR index, and a combined immune-cell death index (ICDI). The PCD and IR indices showed a positive correlation in risk scores, and all three models demonstrated comparable prognostic significance. Given the biological relevance of the immune and cell death pathways, we further investigated the ICDI derived from the key genes FADD, MUC4, CLNK, and CD8B. This analysis included validation against clinical parameters, nomograms, and exploration of immune infiltration. Profiling of drug susceptibility revealed that the high-risk cohort of patients showed resistance to rapamycin and idelalisib but were sensitive to thapsigargin and linsitinib. Overall, the ICDI shows strong potential as a prognostic marker for forecasting clinical outcomes and could facilitate personalized treatment strategies for CC patients. - Source: PubMed
Publication date: 2026/07/06
Kiruba BlessySundararajan Vino - Clear cell renal cell carcinoma (ccRCC) is a prevalent malignancy, representing 80-90% of kidney cancer cases. This study aimed to identify potential prognostic genes to improve patient survival prediction and provide new insights into the pathogenesis and treatment of ccRCC through comprehensive whole transcriptome sequencing analysis. - Source: PubMed
Publication date: 2026/07/08
Chang PengchengQin ZitongLiu RunzhangWang BinxianLu HuaiquanJing SuoshiGuo ChenhaoLi Weiping - Chronic hepatitis B virus (HBV) infection is a major etiological driver of hepatocellular carcinoma (HCC) and is accompanied by profound immune dysregulation that shapes disease progression and therapeutic responsiveness. However, the extent to which systemic immunity reflects the tumor immune microenvironment (TIME) in HBV-related HCC (HBV-HCC) remains incompletely defined. Here, we used mass cytometry (CyTOF) to resolve immune heterogeneity across peripheral blood mononuclear cells (PBMCs), tumor tissues, and matched adjacent non-tumor (paracancer) tissues in treatment-naïve HBV-HCC. PBMCs, tumor tissues, and paracancer tissues were collected from 12 treatment-naïve HBV-HCC patients and profiled by CyTOF. Nine major immune lineages/clusters were quantified and compared across compartments. Immune-cell distributions were correlated with virological and clinicopathological features (HBV DNA status, serum alpha-fetoprotein [AFP], tumor differentiation) and 5-year clinical outcomes. Public transcriptomic datasets were further leveraged for external validation of CD8A/CD8B-associated prognostic signals. HBV-HCC exhibited marked systemic-local immune compartmentalization. PBMCs were enriched for naïve CD8⁺ T cells and natural killer (NK) cells, whereas paracancerous tissues showed higher abundance of myeloid-derived suppressor cells (MDSCs) and memory CD8⁺ T cells. In contrast, HCC tissues were characterized by increased neutrophils and regulatory T (Treg) cells, together with a more activated and immunosuppressive marker profile in HCC-associated MDSCs. HBV DNA-positive patients showed higher intratumoral expression of naïve CD8⁺ T cells and Tregs than HBV DNA-negative patients, with the increase being most evident in HCC tissues relative to matched paracancerous tissues. Clinically aggressive phenotypes, including high AFP, poor differentiation, and postoperative recurrence, were characterized by neutrophil expansion accompanied by reduced PD-1⁺ dendritic cells (PD-1⁺ DCs) and decreased naïve/memory CD8⁺ T-cell subsets. Although higher CD8A/CD8B expression in public datasets predicted improved survival, CyTOF indicated that abundant intratumoral CD8⁺ infiltration could coexist with systemic and intratumoral immunosuppression and functional exhaustion, consistent with the recognized challenge of reinvigorating exhausted intrahepatic immunity. HBV-HCC is defined by profound immune heterogeneity across blood, tumor, and adjacent non-tumor compartments. Distinct immune signatures associate with virological activity, tumor aggressiveness, and long-term outcomes, providing a rationale for immune-based patient stratification and for combinatorial immunotherapy strategies targeting both myeloid-driven suppression and dysfunctional T-cell immunity. - Source: PubMed
Publication date: 2026/07/02
Li YadiWang WenjingZeng AjuanZheng XiaoqinLyu LingnaDing HuiguoWang Shanshan - BH3 mimetics are apoptogenic but rarely cause immunogenic cell death (ICD), limiting durable antitumor immunity. We hypothesized that an ICD-inducing immunoadjuvant could convert BH3-mimetic-triggered tolerogenic apoptosis into immunogenic priming, enhancing checkpoint immunotherapy and overcoming immune evasion in AML. We in vivo evaluated the hydroxycoumarin OT-55, combined with the Bcl-xL inhibitor A-1331852, to enhance PD-1/Tim-3 blockade in Bcl-xL-dependent murine prophylactic and bilateral AML vaccination models. To define the clinical and immunological context, we derived a nine-gene AML ICD score (ATG5, CALR, CD8A, CD8B, IFNGR1, IL1B, PDIA3, PIK3CA, TLR4) by screening 34 ICD-associated genes in transcriptomes of three AML patient cohorts (TARGET-AML, BEAT-AML, GSE37642), retaining genes consistently associated with favorable prognosis (HR < 1, Cox regression). These cohorts were dichotomized by median ICD score to infer immune composition (CIBERSORTx) and profile driver mutations, and to assess blast maturation. High ICD scores were associated with an immune-activated state, increased CD8⁺ T cells, activated dendritic cells, and higher HAVCR2 (Tim-3) expression, consistent with a survival advantage. Bone marrow scRNA-seq from AML and healthy donors revealed ICD-related and progenitor-to-intermediate exhausted T cells, alongside T cell depletion in myelomonocytic AML. Experimentally, we used murine C1498 myelomonocytic AML cells to evaluate OT-55 combined with A-1331852 by prophylactic whole-cell vaccination for DAMP release, dependency testing (CRT neutralization and apyrase), antigen-specific CD8⁺ responses, and synergy with anti-PD-1/anti-Tim-3 therapy in a bilateral tumor model, while monitoring hematologic and serum parameters. OT-55 reduced C1498 viability, induced CRT exposure and ATP release, and conferred CRT/ATP-dependent, but HMGB1-independent, vaccine protection. While A-1331852 was cytotoxic yet weakly immunogenic, its combination with OT-55 enhanced DAMP release, increased CD8⁺ effector functions, and, with PD-1/Tim-3 blockade, achieved local and distant tumor control with low toxicity. These findings identify OT-55 as an immunogenic adjuvant converting tolerogenic BH3 mimetic-driven apoptosis into ICD, providing a proof-of-concept immunogenic treatment for myelomonocytic AML. - Source: PubMed
Publication date: 2026/07/01
Lee YejinKwon Eun-JiGajulapalli Sruthi ReddyPaik Ji YeonOrlikova-Boyer BarboraSilva Artur M SCha Hyuk-JinCerella ClaudiaDiederich Marc - The role of heritable genetic variation in hematologic traits in adults is well established, yet the genetic architecture of neonatal blood cell traits is unknown. Leveraging flow cytometry profiling in cord blood samples from 382 Hispanic newborns, we conducted genome-wide association studies (GWASs) of 24 blood cell phenotypes to assess the impact of genetic and birth-related characteristics. We identified six genome-wide significant loci, including a signal at chromosome 2p11.2 spanning CD8A and CD8B that was associated with CD4CD8 double-positive T cells (rs35505884-C: p = 6.83 × 10). The lead variant showed strongly differentiated allele frequencies between European (22.1%) and admixed American (11.8%) populations and was associated with global (p = 2.51 × 10) and local (p = 2.01 × 10) Indigenous American ancestry. Colocalization with single-cell expression quantitative trait loci (eQTLs) revealed convergence of GWAS effects with regulation of CD8A expression in natural killer cells and CD4 effector memory T cells with posterior probability (PP) >0.85. A locus at 6p21.33 was associated with CD4CD8 cytotoxic T cells (rs2853973-C, p = 3.90 × 10) and colocalized with MICA-AS1 expression across multiple immune cell types (PP > 0.85). Additional nominal genome-wide significant loci were detected for total CD45 lymphocytes, CD19CD56CD16 natural killer cells, and CD4CD8 helper T cells. C-section delivery and biological sex significantly altered blood cell profiles, with the largest magnitudes of association observed between C-section and total CD3 T cells (β = 0.39) and CD4 helper T cells (β = 0.39), and between female sex and CD4CD8 (β = 0.39) and CD4CD8 T cells (β = -0.36). Our study demonstrates that blood cell composition at birth is under strong genetic regulation in Hispanic newborns, highlighting the value of studying complex traits in early life. - Source: PubMed
Publication date: 2026/07/01
Li YunqiAlonzo BenjaminZhang Zixuan ELangie JalenMyint Swe SweInce MichaelaLu RongChiang Charleston W KGazal StevenMancuso NicholasKachuri Lindade Smith Adam J