Aqp5 siRNA_Lentivectors
- Known as:
- Aqp5 siRNA_Lentivectors
- Catalog number:
- i065644c
- Product Quantity:
- 500ng
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Aqp5 siRNA_Lentivectors
Related genes to: Aqp5 siRNA_Lentivectors
- Gene:
- AQP5 NIH gene
- Name:
- aquaporin 5
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 12q13.12
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-25
- Date modifiied:
- 2016-10-05
Related products to: Aqp5 siRNA_Lentivectors
Related articles to: Aqp5 siRNA_Lentivectors
- Autopsy assessment of drowning deaths remains a challenging task for forensic pathologists, requiring a comprehensive multidisciplinary approach. Drowning is typically diagnosed by exclusion, relying on careful evaluation of autopsy, toxicological, and histological findings. However, definitive pathognomonic autopsy features remain elusive. In recent years, numerous immunohistochemical studies on drowning cases have yielded intriguing results. Yet, despite promising findings in the literature, no specific marker is currently employed in routine forensic practice to provide a definitive diagnosis. This study delves into the cerebral cortex expression of AQP4, AQP5, AQP9, AVP, and GFAP, aiming to: (1) identify novel markers potentially useful for drowning diagnosis; (2) explore different pathways in saltwater drowning (SWD) and freshwater drowning (FWD), which can help in understanding the pathophysiology. A retrospective analysis was conducted, selecting 10 cases of FWD (Lake Geneva) from the University Center of Legal Medicine, Lausanne, Geneva (Switzerland) and cases of SWD (Mediterranean Sea) from the Institute of Legal Medicine of Genoa (Italy). As a control group (CC), we included 10 cases of death by acute external bleeding. A strong expression of AQP4 was significantly (p < 0.05) more evident in FWD cases compared to SWD and control cases. Our study findings suggest an activation of AQP4 in response to the osmotic stimulus and haemodilution that occur during FWD. These markers hold promise for differential diagnosis between freshwater and saltwater drowning. The identification of AQP4 as potential differential diagnostic markers for drowning represents a significant step forward in the forensic evaluation of these cases. Further research is warranted to validate these findings and establish their applicability in routine forensic practice. - Source: PubMed
Publication date: 2026/09/22
Barranco RosarioVentura FrancescoFracasso Tony - To investigate the efficacy and potential mechanisms of tripterygium glycosides (TG) and human umbilical cord mesenchymal stem cells (hUC-MSCs) in the treatment of primary Sjögren's syndrome (PSS). - Source: PubMed
Publication date: 2026/08/15
Zhang JingLi XiaoqianWang YikeHao JingZhou Yan - The forensic determination of heatstroke (HS) death remains challenging due to the lack of specific autopsy findings and histopathological changes. The diagnostic biomarkers reported in previous studies have not yet been effectively applied in forensic practice. The skin forms the primary interface between the body and the external environment and is central to heat exchange and thermoregulation. Therefore, the skin may capture both local thermal injury and peripheral responses associated with fatal heatstroke, suggesting its potential value as a biological sample for forensic investigation. Additionally, individual biomarkers are often insufficient to fully reflect the complex processes underlying death, whereas integrating multimodal information may improve diagnostic accuracy. Herein, we conducted a preliminary multimodal analysis to evaluate the forensic potential of skin in a rat model of fatal heatstroke, using functional assessment, HE staining, toluidine blue staining, and immunohistochemical detection of HSP72, Caspase-3, and AQP5. HE staining revealed enlarged secretory lumens and apparent shrinkage of sweat gland secretory cells in HS rats, while toluidine blue staining showed increased dermal mast-cell degranulation. Immunohistochemistry demonstrated increased HSP72, total Caspase-3, and AQP5 immunoreactivity in sweat gland secretory cells, with HSP72 and total Caspase-3 also elevated in the epidermis. PCA suggested clearer group separation when morphological and immunohistochemical variables were considered jointly. Among the individual variables, the mast-cell degranulation ratio showed the best discriminatory performance, with an AUC of 0.9792 (95% CI, 0.9309-1.000). An exploratory random forest classifier integrating seven prespecified variables achieved an internally cross-validated AUC of 1.000 (95% CI, 1.000-1.000) using leave-one-out cross-validation. Overall, this study provides preliminary evidence that skin changes may contribute to forensic assessment of fatal heatstroke. - Source: PubMed
Publication date: 2026/09/18
Liu HuinePan MeichenMa ChuxiongSun ChangaoZhu WeiweiDong Hongmei - Chronic sleep deprivation (SD) is an increasing risk factor for dry eye disease (DED); however, effective nutritional interventions remain limited. In this study, we investigated the protective efficacy of a standardized wild green oat extract (GOE; L.), a polyphenol-enriched supplement with neuromodulatory and antioxidant properties, against SD-induced DED in mice. Mice were subjected to 16 days of SD and orally administered GOE (10 and 40 mg kg, twice daily) from days 5 to 16. SD significantly impaired tear secretion by downregulating lacrimal aquaporin 5 (AQP5) and compromised tear film stability by reducing meibomian PPAR-γ-driven lipogenesis. GOE treatment significantly increased tear secretion, enhanced tear film stability, and preserved tissue integrity. Mechanistically, GOE exerted a dual regulatory effect by modulating cAMP-mediated AQP5 trafficking in lacrimal glands and PPAR-γ/FASN-driven meibocyte differentiation in meibomian glands, restoring ocular surface and tear film homeostasis. These results demonstrate that GOE improves ocular surface health , suggesting its potential as a functional food intervention for SD-related dry eye. - Source: PubMed
Publication date: 2026/09/18
Chang Ya-TingLu LingWang Ping-HsunHsieh Yi-HsienCheng Chun-WenYeh Yong-QingChen Tzu-YuChen Hui-JuHuang Yu-ChunChen Bo-Yie - Salivary gland defects from tumors or trauma are often accompanied by irreversible secretory dysfunction and remain a clinical challenge. Alternative cell sources and suitable scaffolds for salivary gland regeneration remain lacking. A functionalized scaffold system is fabricated by three-dimensional printing combined with freeze-drying to prepare a collagen-silk fibroin-Matrigel scaffold. The scaffold exhibits high porosity and strong water absorption capacity. Its internal surface is coated with a basement membrane extract-rich layer that enhances hydrophilicity and creates a physiologically relevant cell niche. In vitro, a synergistic co-culture system incorporating urine-derived induced pluripotent stem cells (iPSCs), parotid mesenchymal stem cells, and parotid epithelial cells directs the differentiation of iPSCs into KRT18+/VIM+/AQP5+ iPSC-derived cells. These cells readily adhere to the scaffold, proliferate, and form acinar-like aggregates within its porous architecture. In a rat model of parotid gland trauma, implantation of the scaffold progressively promotes tissue regeneration and attenuates trauma-induced atrophy. Histological analysis reveals that the scaffold recruits host cells to organize within its pores, forming amylase-secreting acinar-like structures. This study provides a reliable seed cell source and a suitable scaffold for structural and functional parotid restoration, offering a potential strategy for salivary gland tissue engineering. - Source: PubMed
Publication date: 2026/09/11
Liu HanSun ZiyanJin YizhouLi RuixinShan Zhaochen