Aqp3 siRNA_Lentivectors
- Known as:
- Aqp3 siRNA_Lentivectors
- Catalog number:
- i065517a
- Product Quantity:
- 500ng
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Aqp3 siRNA_Lentivectors
Related genes to: Aqp3 siRNA_Lentivectors
- Gene:
- AQP3 NIH gene
- Name:
- aquaporin 3 (Gill blood group)
- Previous symbol:
- -
- Synonyms:
- GIL
- Chromosome:
- 9p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-25
- Date modifiied:
- 2019-04-23
Related products to: Aqp3 siRNA_Lentivectors
Related articles to: Aqp3 siRNA_Lentivectors
- This study evaluated the effects of live and heat-killed HP7 on intestinal motility, host physiological responses, and gut microbiota in a mouse model of delayed intestinal transit. BALB/c mice were treated with live HP7 (HP7L), heat-killed HP7 (HP7K), or bisacodyl following loperamide administration. HP7L and HP7K improved intestinal motility-related parameters, including fecal output, stool consistency, fecal moisture content, and charcoal meal transit. HP7 treatment also modulated circulating gastrointestinal hormones and inflammatory cytokines, with changes in serotonin, ghrelin, peptide YY, IL-6, and IL-17A. In intestinal tissues, HP7 regulated the expression of genes related to neuroendocrine signaling, water transport, mucus production, and tight junction integrity, including and . Histological analysis further showed reduced colonic tissue alterations and improved structural parameters. Microbiota analysis revealed that HP7L exerted broader effects on microbial community structure, whereas HP7K induced more selective taxonomic changes. Predicted functional profiling suggested that both HP7L and HP7K were associated with shifts in carbohydrate metabolism-related pathways, with HP7K showing additional predicted enrichment of pathways related to redox-associated metabolism, lipid metabolism, and microbial substrate utilization. These findings suggest that heat-killed HP7 retains biological activity and has potential as a postbiotic candidate for regulating intestinal motility. - Source: PubMed
Publication date: 2026/07/01
Gwon HyeonjunKim HyeonjiKim Joo-YunShim Jae-JungLee Jae-Hwan - Extremely low-frequency pulsed electromagnetic fields are used as a biotherapy method in various medical and experimental applications. However, the cellular effects of prolonged or intense exposure remain unclear. This study aimed to evaluate the effects of two different ELF-PEMF doses on kidney tissue over an 8 week period, investigating oxidative stress, apoptosis, inflammation, and aquaporin expression using biochemical, histopathological, and immunohistochemical methods. Forty male rats were assigned to control, sham, 1 mT, and 5 mT groups; the 1 mT and 5 mT groups were exposed to ELF-PEMF for four hours daily for eight weeks, while controls received no intervention. At the end of the experiment, kidney tissues were collected for histopathological (H&E and PAS), immunohistochemical and biochemical analyses. In kidney tissue exposed to ELF-PEMF, hyperemia, tubular degeneration, and proteinaceous casts were observed. 1 mT and 5 mT ELF-PEMF exposure increased BAX, Caspase-9, and TNF-α immunoreactivity compared to the control and sham groups, while no change was observed in BCL-2 expression. 5 mT group exposure to ELF-PEMF increased AQP3 expression, a critical water channel in cellular HO permeability (p < 0.05). AQP5 expression was significantly increased in both the 1 mT and 5 mT groups compared to the control group (p < 0.05). Biochemical analyses showed that oxidative stress levels were significantly increased in both the 1 mT and 5 mT groups compared to the control group (p < 0.05). These findings suggest that, despite its recent use for its therapeutic properties, long-term exposure to ELF-PEMF may cause oxidative stress, apoptosis, and inflammation in renal tissue and alter the histological structure and cellular homeostasis. - Source: PubMed
Publication date: 2026/07/06
Pekince Özöner MerveSeker UgurSert CemilTuysuz Mehmet ZahidYüksel MeralGökçe Yasin - Proteins directly impact disease development and act as drug targets. Therefore, we integrated genomic and lung tissue proteomics data to identify lung cancer susceptibility proteins, elucidating genetic mechanisms and candidate drug targets. - Source: PubMed
Publication date: 2026/06/22
Xu ShuaiShi JiajunShu Xiao-OuTao RanDou YongchaoGuo XingyiWen WanqingYang YaohuaZhang BingWu JieDeppen Stephen ALi BingshanZheng WeiLong JirongCai Qiuyin - Aquaporins (AQPs) are integral membrane proteins that are crucial for maintaining fluid homeostasis in the female reproductive system. This study aimed to determine the immunolocalization and protein expression levels of AQP1, AQP2, AQP3, and AQP4 in rat ovaries at postnatal days 1, 5, 15, 30, and 70. AQP1 immunoreactivity was detected in the cytoplasm and nuclei of oocytes and granulosa cells in follicles on postnatal days 1, 5, and 15. It was found to increase from day 30 onward. AQP2 immunoreactivity was positive only in the zona pellucida from postnatal day 5 onward. The AQP3 immunoreaction was similar to that of AQP1, with a particularly strong reaction in smooth muscle cells located in the walls of blood vessels. AQP4 immunoreactivity was found to be strongly positive in the cytoplasm of oocytes and granulosa cells on the postnatal days examined, and this reaction was higher than that observed in theca and luteal cells. Western blot analysis revealed that AQP1 protein expression levels were high on postnatal days 30 and 70 compared with other postnatal days. These data support the idea that AQPs are local regulators of water metabolism in oogenesis, folliculogenesis, and antrum formation during postnatal development. - Source: PubMed
Alan EmelAlan AydınGram AykutLiman NarinKüçük Bayram GünerBeyaz FeyzullahKorkmaz Alev - Dilated cardiomyopathy (DCM) is the most common non-ischemic cardiomyopathy and a major cause of heart failure, but disease-specific molecular biomarkers remain limited. This study aimed to identify and prioritize tissue-level, disease-responsive candidate biomarkers for DCM using an integrative multi-omics bioinformatics framework. - Source: PubMed
Publication date: 2026/06/09
Li JingweiSong ZhongyangWang GuanweiChen YuchanCheng JiamiaoZhang Zhiming