Prkcd siRNA_Lentivectors
- Known as:
- Prkcd siRNA_Lentivectors
- Catalog number:
- i064789d
- Product Quantity:
- 500ng
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Prkcd siRNA_Lentivectors
Related genes to: Prkcd siRNA_Lentivectors
- Gene:
- PRKCD NIH gene
- Name:
- protein kinase C delta
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 3p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1991-08-06
- Date modifiied:
- 2019-04-23
Related products to: Prkcd siRNA_Lentivectors
Related articles to: Prkcd siRNA_Lentivectors
- Leniolisib, a selective phosphoinositide 3-kinase δ (PI3Kδ) inhibitor, is approved in several countries for the treatment of activated PI3Kδ syndrome (APDS) in patients 12 years of age and older. We report the first successful compassionate use of leniolisib in another inborn error of immunity, protein kinase C δ deficiency. In addition to infectious complications, the 14-year-old patient experienced lymphoproliferation in the form of splenomegaly, lymphadenopathy, and thymic hyperplasia; trilineage cytopenia; multiple forms of autoimmunity; and interstitial lung disease. Decision to initiate treatment with leniolisib was based on multiorgan-disease progression, lack of therapeutic alternatives, molecular evidence, overlap with APDS manifestations, and mammalian target of rapamycin hyperactivity. We observed improvement in lymphoproliferation, cytopenias, hepatic cytolysis, skin manifestations, pulmonary function, favorable changes in immunophenotypes, and no known drug-related adverse events. This experience supports expanding Leniolisib's potential indications to appropriately selected patients and conditions. Broader repurposing strategies for targeted therapies in diseases involving dysregulated PI3K signaling should be systematically evaluated in clinical trials. - Source: PubMed
Publication date: 2026/04/20
Lodi LorenzoGuarnieri ValentinaPeri MatildeBaronio ManuelaRicci SilviaCanessa ClementinaLippi FrancescaVoarino MartaCalistri ElisaPisano LauraPerrone AnnaFenu GraziaIndolfi GiuseppeLougaris VassiliosMarsh Rebecca AAzzari Chiara - Monogenic lupus is a rare, early-onset form of lupus caused by high-penetrance genetic variants, with diverse clinical features and a central role for type I interferon (IFN-I) in its pathogenesis. Standard treatments are lacking, but Janus kinase (JAK) inhibitors show promise, especially in refractory cases. - Source: PubMed
Publication date: 2026/02/04
Al-Mayouf Sulaiman MAlAsmari AliAl-Saleem Alhanouf - Sensory processing in the amygdala is a complex, dynamic process. Decades of surgical, electrical, pharmacological, optogenetic, and chemogenetic manipulations have revealed the nociceptive functions of anatomically- and genetically-restricted neuronal populations. In parallel, molecular and electrophysiological approaches have allowed for high-resolution, temporal examination of nociceptive-induced alterations in amygdala plasticity. Computational integration of this data is critical for future therapeutic development; in practice, these models would allow for prediction of amygdala activity following injury, and in a reciprocal fashion, changes in pain-like behaviors following manipulation of discrete amygdala neuronal populations. To this end, we developed a three-dimensional computer model of the bilateral central nucleus of the amygdala (CeA). We employed agent-based modelling to integrate wet-lab data from two CeA cell populations: Calcitonin Gene-Related Peptide Receptor (CGRPR; ) expressing cells and Protein Kinase C delta (PKCδ; ) expressing cells. We integrated the spatial location, connectivity, neuronal activity, and electrophysiological properties of these neurons in our realistic bilateral model architecture. Our model captures properties of the amygdala that drive pain modulation, including hemisphere-specific physiological differences, and generates predictions of nociception related to bladder injury. Predictions from the model were compared retrospectively to pain outcomes during manipulation of CGRPR-expressing neurons in whole mice. These comparisons show strong alignment between our model and outcomes. - Source: PubMed
Publication date: 2026/04/28
Paul Blesson KKwiatkowski MeganZhantibiyeva FatimaSingh SudhumanNguyen ClaireDevi Singari Sri VaishnaviPerumal Chris DavisAnandan IniyaAdke Anisha PSadler Katelyn ECarrasquillo YarimarNeilan Rachael MillerKolber Benedict J - Colorectal cancer (CRC) is the leading cause of cancer-related deaths worldwide. Colon adenocarcinoma (COAD), the most common histological subtype, is characterized by a poor prognosis in advanced stages due to significant molecular heterogeneity. Protein kinase C delta (PKCδ), encoded by PRKCD, is a context-dependent regulatory kinase in tumor biology. Its expression, genomic alterations, and binding interactions with phytochemicals from Phoenix dactylifera were studied using a comprehensive in silico approach. PRKCD was found to be downregulated in all TCGA-COAD tumor subgroups when compared to normal tissue. The survival analysis failed to show a statistically significant association between PRKCD expression and overall or disease-free survival; thus, the protein is more likely to be a biological modulator than a prognostic marker. Mutational profiling revealed missense substitutions and copy number variations in COAD. The drug-like properties of 46 phytochemicals from P. dactylifera were evaluated, and only five compounds passed all the filters. Docking against the C2 regulatory domain of PKCδ (PDB ID: 1YRK) revealed (Z)-4-Methoxy-3,3',5,5'-tetrahydroxystilbene (PubChem CID: 13499471) as the highest-scoring ligand at -7.0 kcal/mol. Rottlerin, the validated PKCδ inhibitor, was used as a positive control and had a score of -7.3 kcal/mol at the same binding site. Both complexes were subjected to 100 ns molecular dynamics (MD) simulations under equated conditions. Several parameters, including backbone RMSD, RMSF, radius of gyration (Rg), solvent-accessible surface area (SASA), hydrogen-bond counts, principal component analysis (PCA), and free-energy landscape (FEL) profiling, all indicated stable conformations for the two complexes. The lead phytocompound showed very similar behaviour to the positive control, thereby reinforcing its potential as a PRKCD modulator. The results indicate that further experimental studies on P. dactylifera-derived stilbenoids in COAD are warranted. - Source: PubMed
Adnan MohdSiddiqui Arif JamalAlreshidi MousaSurti MalviPatel Mitesh - Glioblastoma (GBM) is one of the most aggressive brain tumors with a poor prognosis despite current treatment modalities. This study aimed to identify genes whose high expression is paradoxically associated with both poor survival and enhanced immune activity, as potential targets for combination chemotherapeutic and immunotherapeutic strategies. - Source: PubMed
Publication date: 2026/04/27
Han Myung-HoonNoh Yung-KyunKim HyunkeeKim Kyu ShikKim Dong-HoonJung Un SukLee Kyung SukKwon Mi JungChae Seoung WanMin Kyueng-Whan