Psph siRNA_Lentivectors
- Known as:
- Psph siRNA_Lentivectors
- Catalog number:
- i063857d
- Product Quantity:
- 500ng
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Psph siRNA_Lentivectors
Related genes to: Psph siRNA_Lentivectors
- Gene:
- PSPH NIH gene
- Name:
- phosphoserine phosphatase
- Previous symbol:
- PSP
- Synonyms:
- -
- Chromosome:
- 7p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2014-11-19
Related products to: Psph siRNA_Lentivectors
Related articles to: Psph siRNA_Lentivectors
- Activation of YAP during the acute phase of pressure overload induces compensatory cardiac hypertrophy by activating aerobic glycolysis. One potential mechanism mediating the salutary action of YAP is an accumulation of serine, which provides building blocks essential for the growth and survival of cardiomyocytes. We investigated the molecular mechanism through which YAP promotes serine accumulation in the heart during the acute phase of pressure overload. Overexpression of YAP upregulated PHGDH, PSAT1, PSPH, components of the serine synthesis pathway (SSP), and SHMT1, but not SHMT2, an enzyme involved in interconversion between serine and glycine, in cardiomyocytes at both the mRNA and protein levels. Upregulation of these enzymes during transverse aortic constriction (TAC) was abolished in cardiac specific Yap knockout (Yap-chKO) mice. Downregulation of Phgdh attenuated YAP-induced increases in SSP metabolites, including phospho-serine, serine, glycine and S-adenosylmethionine, in cultured cardiomyocytes. YAP also upregulated ASC-1, a serine transporter, in cardiomyocytes, and YAP-induced increases in serine content in cardiomyocytes were decreased in the presence of Asc-1 knock-down. YAP-induced increases in cardiomyocyte cell size were inhibited in the presence of siRNA targeting Phgdh, Psat1, Psph, Shmt1 or Asc-1, suggesting that the increase in serine content plays an important role in mediating YAP-induced hypertrophy in cardiomyocytes. TAC increased binding of YAP and TEAD1 to the promoters of the SSP genes, whereas YAP-induced upregulation of PHGDH and PSAT1 was inhibited in the presence of TEAD1 downregulation. These results suggest that YAP directly promotes expression of genes involved in serine synthesis and uptake in cardiomyocytes, and that upregulation of the serine content plays an important role in mediating YAP-induced cardiac hypertrophy. - Source: PubMed
Publication date: 2026/06/05
Hu ChengchenZhai PeiyongSu XiaoyangRamoszepeda JacquelineChiles EricKhatimah Nurul GustiIkeda SoichiroKass David ASadoshima Junichi - The aim was to evaluate serum levels of Phosphoserine Phosphatase (PSPH) and Chemokine C-X-C Motif Ligand 2 (CXCL2) as biomarkers for predicting antipsychotic treatment response in male first-episode schizophrenia patients. - Source: PubMed
Zheng Jingjing - This study aims at understanding the important correlates of child undernutrition in India using a quantile regression approach. - Source: PubMed
Publication date: 2026/05/18
Singh AkanchaShri NehaSingh Saurabh - BackgroundMusculoskeletal disorders (MSDs), which impose significant economic and mental health burdens, are a major public health concerns among older population globally. However, evidence on the intersection between MSDs and depression among older adults in India remains limited.ObjectiveThe objective of the study is to investigate the association between musculoskeletal disorders and depression among older Indian adults using nationally representative data.MethodsCross-sectional data from the first wave of the Longitudinal Ageing Study in India (LASI, 2017-2018) were analyzed for 65,311 participants. Depression was measured by validated tool the Composite International Diagnostic Interview-Short Form (CIDI-SF). Binary logistic regression analysis was employed to examine the nexus between musculoskeletal disorders and depression in middle-aged and older adults.ResultsThe results indicate a significant association between musculoskeletal disorders (MSDs) and depression. After adjusting for covariates, the odds of experiencing depression among those who experienced joint pain or stiffness (aOR: 1.19, CI 1.11-1.29), foot or ankle pain/swelling (aOR: 1.55, CI 1.43-1.68), and back pain or problems (aOR: 1.28, CI 1.19-1.38) were higher compared with those reporting no such conditions. Similarly, individuals who experienced falls or injuries had 50% higher odds of depression (aOR: 1.50, CI 1.38-1.63) than those who didn't experienced falls or injuries.ConclusionAlthough causality cannot be established due to the cross-sectional nature of the study, findings highlight the strong association between MSDs and depression among older adults in India. These results underscore the need for physicians to address mental health alongside MSDs management and to promote preventive and educational programs. - Source: PubMed
Publication date: 2026/05/05
Khanal GayatriSelvamani YesuvadianBist OmkarSingh SaurabhManandhar Ruby - Bovine tuberculosis (bTB), caused by (), remains an ongoing global issue for human and animal health. The Bacille Calmette Guerin (BCG) vaccine offers immunity against bTB, however, the mechanisms underlying the heterogenous protective response, including variations across species and age groups requires further investigation. In this study, we focused on dendritic cells (DCs), which are crucial for adaptive immune stimulation following BCG vaccination. By capturing afferent lymph DCs (ALDCs) migrating from the skin, we investigated shifts in DC profiles and potential subset-specific functions in response to BCG vaccination. Single-cell RNA sequencing (scRNA-seq) was performed on samples from calves (n=3) before and after BCG vaccination, capturing the transcriptome of 20,761 individual cells expressing on average 3,036 genes, which were clustered into ALDCs, monocytes, T-cells, B-cells and NK cells. The ALDC subsets were further identified as cDC1 and cDC2. In homeostasis, ALDCs expressing potential subset-specific genes for cDC1, including ENSBTAG00000056208, , , , , and cDC2; , , , , and were identified. Following BCG vaccination, while both DC subsets exhibited gene expression signatures indicative of antigen-presenting function, migration, and DC maturation, cDC1 showed upregulation of genes consistent with metabolic alterations and lymphocyte recruitment, whereas cDC2 upregulated genes consistent with inflammatory responses. Overall, this study comprehensively describes the transcriptomic landscape of bovine ALDC subsets, providing evidence for the importance of subset-specific genes to BCG vaccination responses, while advancing knowledge on how ALDCs contribute to protective immunity against bTB. - Source: PubMed
Publication date: 2026/04/07
Sukmak RachrapeeMathie Heather ATaylor Richard SSun JianxuanShih BarbaraBell Charlotte RGray MarkMacqueen Daniel JHope Jayne C