ITLN1, 17-313aa, Human, E.coli
- Known as:
- ITLN1, 17-313aa, Human, E.coli
- Catalog number:
- ATGP1125
- Product Quantity:
- 0.5mg
- Category:
- -
- Supplier:
- ATGen
- Gene target:
- ITLN1 17-313aa Human .coli
Related genes to: ITLN1, 17-313aa, Human, E.coli
- Gene:
- FCN2 NIH gene
- Name:
- ficolin 2
- Previous symbol:
- -
- Synonyms:
- P35, FCNL, EBP-37, ficolin-2
- Chromosome:
- 9q34.3
- Locus Type:
- gene with protein product
- Date approved:
- 1996-07-11
- Date modifiied:
- 2016-10-05
- Gene:
- ITLN1 NIH gene
- Name:
- intelectin 1
- Previous symbol:
- -
- Synonyms:
- ITLN, FLJ20022, LFR, HL-1, hIntL
- Chromosome:
- 1q23.3
- Locus Type:
- gene with protein product
- Date approved:
- 2003-03-14
- Date modifiied:
- 2016-10-05
Related products to: ITLN1, 17-313aa, Human, E.coli
Related articles to: ITLN1, 17-313aa, Human, E.coli
- In brief: Omentin-1 enhanced in vitro oocyte maturation by increasing the percentage of oocytes in metaphase II, progesterone levels, mitochondrial functions, and lipolysis via extracellular signal-regulated kinase 1/2 and AMP-activated protein kinase alpha 1, without effect on preimplantation embryo development. Abstract: Oocyte maturation is a critical stage in embryo development and female reproduction, and is regulated by adipokines-hormones produced by adipose tissue. Omentin-1 (ITLN1) is an adipokine known to regulate ovarian follicle function, however its role in oocyte maturation remains unclear. This study investigated ITLN1 expression in porcine oocytes and cumulus cells before and after in vitro maturation (quatitiative real-time PCR, western blotting, immunofluorescence) and the effect of ITLN1 on: oocyte maturation by assessing the percentage of oocytes in metaphase II (M2) (4',6-diamidino-2-phenylindole, DAPI) and progesterone (P4) secretion (enzyme-linked immunosorbent assay); glucose metabolism, including glucose transporter type 4 (GLUT4) expression, glucose and lactate secretion, and mitochondrial function (Seahorse Test); lipid metabolism, as assessed by lipid droplet area (Nile Red), and adipose differentiation-related protein and adipose triglyceride lipase (ATGL) expression; extracellular signal-regulated kinase 1/2 (ERK1/2) and AMP-activated protein kinase alpha 1 (PRKAA1) phosphorylation, which mediate the effects of ITLN1 on oocyte maturation. Moreover, the effect of ITLN1 on preimplantation embryo development was also examined. ITLN1 expression increased after maturation in both oocytes and cumulus cells, with strong immunofluorescence signals in both cells. ITLN1 increased oocyte maturation to the M2 stage and P4 secretion. It enhanced glucose metabolism by upregulating GLUT4 and reducing glucose and lactate levels, improved mitochondrial function, reduced lipid droplet area, upregulated ATGL expression, and stimulated ERK1/2 and PRKAA1 phosphorylation. However, ITLN1 had no significant effect on preimplantation embryo development. In conclusion, ITLN1 positively regulates porcine oocyte maturation in vitro through coordinated modulation of energy metabolism, mitochondrial activity, lipid utilization, and ERK1/2-PRKAA1 signalling. - Source: PubMed
Kubicka KarolinaRespekta-Długosz NataliaKurowska PatrycjaMarynowicz WeronikaSmolińska NinaDawid MonikaKostilek MałgorzataBryła MagdalenaTrzcińska MonikaRak Agnieszka - Appetite regulation in vertebrates involves central neuropeptides and peripheral metabolic and endocrine signals that act together to maintain energy homeostasis. These include orexigenic (e.g., neuropeptide Y, orexin, ghrelin) and anorexigenic (e.g., cocaine- and amphetamine-regulated transcript, corticotropin-releasing factor, cholecystokinin, leptin) factors coordinate feeding behavior. Intelectin-1 (ITLN1), a protein implicated in innate immunity and metabolic signaling in mammals, has not yet been investigated in the context of fish feeding physiology. This study examined the potential role of ITLN1 in appetite regulation and energy metabolism in goldfish (Carassius auratus). We first determined tissue distribution of itln1, which showed highest mRNA levels in spleen and liver and lower expression in brain, intestine, kidney, and gonads. Short-term fasting reduced itln1 expression in the hypothalamus and intestine, but not in liver. Peripheral administration of recombinant human ITLN1 (250-500 ng/g) significantly reduced food intake without altering blood glucose. At the highest dose (500 ng/g), ITLN1 increased brain expression of anorexigenic neuropeptides cart1, crf, trh, cck and lep2, intestinal expression of cck and inflammatory markers (tnfa, il1b) and hepatic lep2 and glycogen synthase (gs) expressions, with no effect on orexigenic peptides or glucose transporters. These findings suggest that ITLN1 might act as a peripheral satiety signal in goldfish, modulating the expression of anorexigenic neuropeptides, gut hormones, and hepatic metabolic genes. This study provides initial evidence that ITLN1 may contribute to appetite regulation in a teleost, suggesting a potential role in coordinating immunity, nutrient metabolism, and central pathways involved in feeding. - Source: PubMed
Publication date: 2026/06/23
Perry Heidi CVolkoff Helene - Omentin-1 protein has protective effects against coronary artery disease (CAD). The Val109Asp polymorphism (rs2274907) in the Omentin-1 gene has been associated with CAD risk, but this relationship has not been investigated in patients with type 2 diabetes mellitus (T2DM). To investigate the association between the Omentin-1 Val109Asp polymorphism and CAD risk in Han Chinese patients with T2DM. This case-control study enrolled 465 Han Chinese patients with T2DM from July 2008 to September 2015. Participants were classified as CAD-positive (coronary stenosis > 50% in at least 1 major vessel, n = 249) or CAD-negative (n = 216). The Val109Asp polymorphism was genotyped using PCR-RFLP. Logistic regression analysis was performed to assess the association between genotypes and CAD risk, with adjustment for potential confounders including age, sex, smoking status, hypertension, dyslipidemia, diabetes duration, body mass index, and fasting glucose. The A allele frequency was higher in CAD patients than in controls (34.5% vs 27.5%; OR = 1.386; P = .026). Under the dominant model, TA/AA carriers had increased CAD risk compared with TT homozygotes (adjusted OR = 1.509, 95% CI: 1.025-2.222; P = .037). Stratified analyses showed that smokers carrying the A allele exhibited further elevated CAD risk (adjusted OR = 1.82, 95% CI: 1.02-3.27). The Omentin-1 Val109Asp polymorphism is associated with increased CAD risk in Han Chinese patients with T2DM under the dominant genetic model. Stratified findings suggest that smoking may further heighten CAD susceptibility among A-allele carriers. Integrating genetic and lifestyle factors may improve cardiovascular risk assessment in this population. - Source: PubMed
Yu DahongTong LinchaoMa XiaoweiGu NanLu DifeiYu NaWang YuxinZhang JunqingLi JianpingGuo Xiaohui - Hashimoto thyroiditis (HT) is a chronic autoimmune disease that extends beyond abnormalities in thyroid hormone levels. The aim of this study was to evaluate circulating levels of omentin-1, an anti-inflammatory adipokine, and high-mobility group box 1 (HMGB1), an inflammatory alarmin, in patients with HT, and to examine their associations with clinical and biochemical parameters as well as their diagnostic performance. - Source: PubMed
Publication date: 2026/06/20
Genc SelinMercantepe FilizAksu OguzhanCan UmmugulsumKizilarslanoglu Muhammet CemalKlisic Aleksandra - White adipose tissue is now recognized as an active endocrine organ that secretes numerous bioactive molecules known as adipokines. These proteins regulate essential physiological processes, including energy metabolism, inflammation, and reproduction, while disturbances in their secretion are linked to conditions such as infertility, obesity, and diabetes. Omentin-1, also termed intelectin-1, is a secreted trimeric lectin conserved across mammals. In addition to systemic actions that improve insulin sensitivity, enhance glucose uptake, and suppress oxidative stress and inflammation, omentin-1 exerts important functions within the female reproductive system. It is expressed in the hypothalamus, pituitary gland, ovary, oocyte, and placenta, where it influences cell proliferation, apoptosis, and hormone production. Through these actions, omentin-1 contributes to hormonal homeostasis, follicular development, oocyte maturation, luteal function - integrating energy balance with female fertility. Altered circulating or local levels of omentin-1 have been observed in polycystic ovary syndrome, endometriosis, ovarian and endometrial cancers, preeclampsia, and gestational diabetes. This review aims to summarize current knowledge on omentin-1 expression and function in the female reproductive system within hypothalamus - pituitary - ovary axis and its role in reproductive pathologies. - Source: PubMed
Kubicka KarolinaRespekta-Długosz NataliaSzkraba OliwiaKurowska PatrycjaRak Agnieszka