Slc11a1 siRNA_Lentivectors
- Known as:
- Slc11a1 siRNA_Lentivectors
- Catalog number:
- i062721a
- Product Quantity:
- 500ng
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Slc11a1 siRNA_Lentivectors
Related genes to: Slc11a1 siRNA_Lentivectors
- Gene:
- SLC11A1 NIH gene
- Name:
- solute carrier family 11 member 1
- Previous symbol:
- LSH, NRAMP, NRAMP1
- Synonyms:
- -
- Chromosome:
- 2q35
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-21
- Date modifiied:
- 2016-02-17
Related products to: Slc11a1 siRNA_Lentivectors
Related articles to: Slc11a1 siRNA_Lentivectors
- Intra-abdominal infection frequently progresses to sepsis, where the liver is an early and commonly injured organ. In a cecal ligation and puncture (CLP) mouse model combined with bulk and single‑cell RNA sequencings, we observed marked neutrophil infiltration in the liver that correlated with injury severity. Sepsis‑associated neutrophils displayed a pro‑inflammatory phenotype and specifically upregulated the divalent metal transporter solute carrier family 11 member 1 (SLC11A1). Conditional knockout of Slc11a1 in neutrophils (Ly6G-Cre Slc11a1) significantly alleviated liver injury and improved survival. Mechanistically, SLC11A1 drives intracellular Fe accumulation and reactive oxygen species production via the Fenton reaction, promoting the formation of neutrophil extracellular traps (NETs). Hepatocytes were found to secrete C-X-C motif chemokine ligand 10 (CXCL10) through nuclear factor kappa B (NF‑κB) activation, which both recruit neutrophils and stimulates the JAK/STAT1/SLC11A1 axis, thereby enhancing NETs‑mediated pro‑inflammatory macrophage polarization. Clinically, peripheral blood CXCL10 levels correlated with liver injury markers in sepsis patients. Neutralization of CXCL10 using an anti-CXCL10 antibody or liver-specific knockdown of CXCL10 via Adeno-Associated Virus (AAV) reduced NETs formation and attenuated liver damage in CLP mice. This study delineates a "CXCL10-SLC11A1-NETs" signaling axis that exacerbates sepsis‑induced liver injury, offering a novel target for therapeutic intervention. - Source: PubMed
Publication date: 2026/07/13
Lin HaipingZheng ShicongSong PeiChang JieChen ZeweiLi CangYu MinWang LudeYu Shian - Myocardial ischemia-reperfusion (MIR) injury remains the leading cause of adverse outcomes after myocardial infarction, and its prevention remains a major therapeutic challenge. - Source: PubMed
Publication date: 2026/06/19
Dong YilinYang HaomingYang FanMeng Liang - Ferroptosis is a critical contributor to cardiomyocyte injury in acute myocardial infarction (AMI). This study aimed to identify key ferroptosis-associated genes and elucidate their roles in AMI. Transcriptomic datasets from AMI patients and healthy controls were analyzed to identify differentially expressed genes (DEGs). The role of the solute carrier family 11 member 1 (SLC11A1) was validated in vitro using a hypoxia/reoxygenation (H/R) model in H9c2 cardiomyocytes and in vivo using a murine AMI model. SLC11A1 expression was elevated in H/R-treated cardiomyocytes and infarcted murine hearts. SLC11A1 silencing reduced infarct size and improved cardiac function, and suppressed ferroptosis. Mechanistically, SLC11A1 led to the transcriptional suppression of glutathione peroxidase 4 (GPX4) mediated by the transcription factor specificity protein 1 (Sp1). This study identifies the SLC11A1-Sp1-GPX4 axis as a pivotal transcriptional regulator pathway driving ferroptosis in AMI. These findings highlight SLC11A1 as a promising therapeutic target in AMI. - Source: PubMed
Publication date: 2026/06/03
Zhang ShirongWang YeshuFeng YangmeiWang FangZhu Jiaqing - Given its high mortality and broad societal impact, the COVID-19 pandemic is arguably one of the most consequential public health crises of the twenty-first century. Although previous studies have identified several genes associated with COVID-19 susceptibility, relatively little is known about the genes contributing to severe COVID-19, including their evolutionary histories. In the current study, we analyzed IL-4, TLR2, CCL2, and SLC11A1-immunity genes that have previously been implicated in severe COVID-19 and other immune-related diseases-in globally diverse populations from the 1000 Genomes Project. We also tested for associations between genetic variation at these genes and clinical COVID-19 phenotypes in nearly 4000 laboratory-confirmed COVID-19-positive individuals across two datasets from the GEN-COVID Multicenter Study in Italy. - Source: PubMed
Publication date: 2026/05/29
Cross Christopher NLisi AlessandroSimmonds Faith CFlores Marisol FerminWashington KareemHeinbockel ThomasCampbell Michael C - Pleural tuberculosis is one of the most frequent extrapulmonary manifestations of infection and is characterized by a pronounced immune-mediated response with a low bacillary burden. Host genetic factors appear to play a central role in its immunopathogenesis. - Source: PubMed
Publication date: 2026/05/02
Neto André AmateOlivo Taylor Endrigo ToscanoMastroianni Patríciade Nadai Mariane NunesForgerini Marcelade Nadai Tales Rubens