Sap18 siRNA_Lentivectors
- Known as:
- Sap18 siRNA_Lentivectors
- Catalog number:
- i061603a
- Product Quantity:
- 500ng
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Sap18 siRNA_Lentivectors
Related genes to: Sap18 siRNA_Lentivectors
- Gene:
- SAP18 NIH gene
- Name:
- Sin3A associated protein 18
- Previous symbol:
- -
- Synonyms:
- SAP18p, 2HOR0202, MGC27131
- Chromosome:
- 13q12.11
- Locus Type:
- gene with protein product
- Date approved:
- 1998-09-21
- Date modifiied:
- 2016-06-01
Related products to: Sap18 siRNA_Lentivectors
18 kDa Sin3-associated polypeptide,2HOR0202,Cell growth-inhibiting gene 38 protein,GIG38,Histone deacetylase complex subunit SAP18,Homo sapiens,Human,SAP18,Sin3-associated polypeptide p1818 kDa Sin3-associated polypeptide,Bos taurus,Bovine,Histone deacetylase complex subunit SAP18,SAP18,Sin3-associated polypeptide p1818 kDa Sin3-associated polypeptide,Histone deacetylase complex subunit SAP18,Mouse,Mus musculus,Sap18,Sin3-associated polypeptide p183 Target siRNA's & 1 negative control duplex. Standard purity, 2 nmol each5x SiRNA Buffer5x SiRNA Buffer5x SiRNA BufferA-SIN3 assoc SAP18 mAb 150µgA1BG predesign siRNAA1BG predesign siRNAAAAS predesign siRNAAAAS predesign siRNAAADAC predesign siRNAAADAC predesign siRNAAAK1 predesign siRNA Related articles to: Sap18 siRNA_Lentivectors
- - Source: PubMed
Publication date: 2026/05/26
- Behavioral and psychological symptoms of dementia (BPSD) are common, profoundly troubling to patients and caregivers, and difficult to treat, yet their molecular underpinnings remain poorly understood. Here, we generated a large brain proteomic dataset with nine BPSD domains assessed in life from 376 donors from three cohorts. Protein associations with BPSD were examined using complementary approaches - domain-specific BPSD, multi-domain BPSD, and latent factor modeling - and integrated via cross-cohort meta-analysis. Four proteins (NMT1, DCAKD, DNPH1, and HIBADH) were associated with anxiety in dementia and five proteins (ABL1, SAP18, PLXND1, CTRB2, and LDHD) with multi-domain BPSD or BPSD latent factors after adjusting for sex, age, and other covariates (FDR < 0.05). Additionally, eight protein co-expression networks were associated with BPSD across cohorts. Together, these results link BPSD to dysregulation of synaptic signaling, protein folding, and humoral immune response, providing a molecular framework for therapeutic discovery. - Source: PubMed
Publication date: 2026/04/24
Vattathil Selina MDuong Duc MGearing MarlaSeyfried Nicholas TWilson Robert SBennett David AWoltjer Randall LWingo Thomas SWingo Aliza P - In the root apical meristem, the stem cell niche (SCN) comprises a mitotically inactive quiescent center (QC) and adjacent, mitotically active stem cells that divide to form root tissues. Auxin dynamics are essential for specification and maintenance of the root SCN; however, the underlying mechanisms remain to be explored. Here, we report that Arabidopsis (Arabidopsis thaliana) AUXIN RESPONSE FACTOR3 (ARF3), ARF3-INTERACTING PROTEIN1/2 (AIP1/2), and SIN3-ASSOCIATED POLYPEPTIDE OF 18 KDA (SAP18) form a protein complex that specifies root SCN cell fate in response to auxin level. In cells proximal to the QC, the ARF3-AIP1/2-SAP18 complex bound the WOX5 promoter and restricted WOX5 expression to the QC by decreasing H3 histone acetylation, thereby maintaining the SCN. Disrupting the ARF3-AIP1/2-SAP18 complex via mutation or exposure to excessive amounts of auxin resulted in proximal and lateral expansion of WOX5 expression and inhibited root elongation by repressing cell division. During de novo specification of the SCN in lateral root primordia or regenerating root tips, accumulated auxin caused the ARF3-AIP1/2-SAP18 complex to dissociate, allowing the induction of WOX5 expression. In the reestablished meristem, the ARF3-AIP1/2-SAP18 complex confines WOX5 expression to the newly formed QC. Our findings provide insights into the roles of auxin dynamics in determining root SCN. - Source: PubMed
Cheng Zhi JuanZhang Meng RuZhang Huan KaiChu Xiao LiLi Bing ZhenZhang Miao MiaoLi Jia YangDong Wan ChenWang De HaoXin Wen QiHan Xin LinYu Cai YuWang Zhi WeiZhang Xiao HangLiu Jiong HuiZhang Xian ShengSang Ya Lin - Acute myeloid leukaemia with normal karyotype (AML-NK) is a cytogenetically cryptic yet heterogeneous clinical subgroup that lacks structural chromosomal abnormalities. Although classified as an intermediate-risk group, AML-NK exhibits variability in patient outcomes, underscoring the need for refined molecular stratification. In this study, high-throughput deep sequencing was performed on 51 AML-NK patients, with a comprehensive analysis of a Southeast Asian cohort to identify cryptic and novel fusion genes potentially implicated in disease pathogenesis and prognosis. Two pipelines (Arriba and STAR-fusion) were utilised in this study, which identified 68 findings involving 27 fusion genes, of which approximately 70% (n = 19/27) were novel. The majority (85%) were intrachromosomal fusion events, and 26% involved non-coding RNAs. The most recurrent and novel fusions were LATS2::SAP18 (17.6%) and HOXA3::HOXA9 (15.7%). In addition, known prognostic fusion genes, KMT2A-PTD, NUP98::NSD1, and NPM1::MLF1, were detected. The integration of these prognostic fusion genes into the ELN 2022 criteria reclassified 73% (n = 8/11) of intermediate-risk patients as poor-risk. Notably, the presence of KMT2A-PTD and/or LATS2::SAP18 was associated with reduced overall survival (p = 0.039, Log-Rank), although this significance was not retained in multivariate analysis. This study's findings revealed the complexity of the AML-NK transcriptome, highlighting the utility of RNA sequencing for prognostic risk assessment and therapeutic strategy development. KEY MESSAGE: RNA-seq uncovered 27 fusion genes in AML-NK, 70% of which were novel. Recurrent LATS2::SAP18 and HOXA3::HOXA9 fusions were identified. Fusion-based ELN 2022 reclassified most intermediate-risk patients. RNA-seq enhances prognostic assessment in AML-NK. - Source: PubMed
Publication date: 2026/01/22
Ambayya AngeliRazali RozaimiSulong SarinaYap Yee YeeSelvaratnam VeenaSathar JameelaHassan Rosline - The relationships between plants and the moonlight is frequently dismissed as a myth, which obstructs a deeper understanding of this topic, but recent work provided evidence for its effect on plant cellular activities and growth. We addressed the involvement of the Arabidopsis epigenetic modifiers DDM1 and SUVH4 in plant responses to full moonlight (FML) by using their corresponding mutants. Wild type (WT) and ddm1 etiolated seedlings responded to FML by apical hook opening and cotyledon unfolding; suvh4 mutant was impaired in skotomorphogenesis. Exposure to FML resulted in notable changes in genome organization and protein and metabolite profiles in WT and ddm1 but not in suvh4. Among the upregulated proteins in WT and ddm1 are those related to photosynthesis such as the photosystem I reaction center subunits PSAK and PSAH1 and chlorophyll a-b binding proteins LHB1B1 and LHCA1 as well as the blue light receptor phototropin 1 (PHOT1) and the phytochrome-associated serine/thronine-protein phosphatase 1 (PYPP1). Using GST pull down coupled proteome analysis we identified the apoptosis and splicing-associated protein (ASAP) SAP18 as a SUVH4 interacting protein. The interaction of SUVH4 with SAP18 was confirmed by GFP-TRAP of proteins extracted from SAP18-GFP expressing plants followed by proteome analysis. Indeed, SAP18-GFP could trap SUVH4 along with SR45 and the Acinus paralog PININ, components of the ASAP complex. Our study highlighted a previously unrecognized link between histone modification by SUVH4 HMTase and the ASAP complex of splicing factors which may facilitate the silencing of active genes and possibly interpret the moonlight signal into a functional state. - Source: PubMed
Publication date: 2025/10/16
Singiri Jeevan RYarra Naveen-KumarSannidhi SasankPriyanka GovindegowdaSwetha BupurNovoplansky NuritAdler-Agmon ZachorGrafi Gideon