Lrrc42 siRNA_Lentivectors
- Known as:
- Lrrc42 siRNA_Lentivectors
- Catalog number:
- i061572b
- Product Quantity:
- 500ng
- Category:
- -
- Supplier:
- ABM
- Gene target:
- Lrrc42 siRNA_Lentivectors
Related genes to: Lrrc42 siRNA_Lentivectors
- Gene:
- LRRC42 NIH gene
- Name:
- leucine rich repeat containing 42
- Previous symbol:
- -
- Synonyms:
- MGC8974
- Chromosome:
- 1p32.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-05-24
- Date modifiied:
- 2018-06-04
Related products to: Lrrc42 siRNA_Lentivectors
Related articles to: Lrrc42 siRNA_Lentivectors
- Ischemic stroke in Saudi Arabia arises in a highly consanguineous population with a distinctive genetic architecture, likely enriching rare coding variants that influence stroke risk. Yet the contribution of these variants to stroke susceptibility, age at onset, and subtype patterns in this setting remains incompletely defined. - Source: PubMed
Publication date: 2026/05/05
Alkhamis FahadAlabdali Majed MAlamri Abdullah SAlali RudaynahHabara Alawi HAkhtar Mohammed SAlkhamis Shahad FRophina MercyAlkhudair Abdullah MVatte ChittibabuKeating BrendanAl-Ali Amein K - Osteoarthritis (OA) has been implicated in the development and progression of early-stage endometrial cancer (EC), suggesting shared pathogenic factors between the two diseases. This study aimed to investigate the causal relationship between OA and EC and to identify causative genes common to both early-stage EC and OA. A Two-sample Mendelian randomization (MR) analysis was first performed to assess the causal relationship between OA and EC. Differentially expressed genes associated with early-stage EC and OA were identified using the limma package. Overlapping genes were extracted to determine common causative genes, followed by enrichment analysis. The causal relationship between these genes and EC was verified through Mendelian randomization (MR) of drug targets. Genes with diagnostic value were identified using multiple machine learning algorithms to construct EC prediction models and evaluate their performance. Additionally, the study examined the correlation between diagnostic-value genes and immune cell infiltration. IVW analysis indicated that OA was a high-risk factor for the development of EC (P < 0.05). Seven common causative genes (CDKN2A, DDA1, LRRC42, POLB, ADCYAP1R1, DNMT3A, and GLRX5) were identified for OA and EC, showing significant enrichment in related pathways such as heterochromatin. MR analysis of drug targets revealed that CDKN2A, DDA1, LRRC42, and POLB had diagnostic value for EC. The EC prediction model based on these four genes demonstrated high performance (AUC = 0.974 for the training set; AUC = 0.966 for the validation set), and these genes were significantly associated with immune cell infiltration (P < 0.05). CDKN2A, DDA1, LRRC42, and POLB may be common causative genes for OA and early-stage EC, potentially serving as targets for drug intervention. - Source: PubMed
Publication date: 2025/07/01
Bai YiyunLuo SangShuai RuzhenZhang XiaomeiYuan LiweiLiu Dan - This study investigated the role of LRRC42 in tumor development and progression using comprehensive methodologies. Analysis of RNA-seq data from the TCGA database revealed that LRRC42 expression is upregulated in various tumor tissues, including bladder cancer (BLCA), breast cancer (BRCA), cholangiocarcinoma (CHOL), colorectal cancer (COAD), esophageal cancer (ESCA), glioblastoma (GBM), head and neck squamous cell carcinoma (HNSC), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), and skin cutaneous melanoma (SKCM), compared to normal tissues. Conversely, LRRC42 was significantly downregulated in kidney chromophobe (KICH) and thyroid carcinoma (THCA) tissues. Single-cell analysis using the TISCH2 database highlighted high LRRC42 expression levels in specific subpopulations across different cancers. Correlation analyses indicated associations between LRRC42 expression and prognosis in multiple tumors, linking it to poor overall survival in several cancer types. Investigations into LRRC42's interactions with the tumor immune microenvironment and signaling pathways demonstrated significant correlations with immune cells, epithelial-mesenchymal transition molecules, autophagy-related factors, and pyroptosis-related molecules. Focusing on LRRC42's potential role in hepatocellular carcinoma (HCC), the study uncovered co-expression relationships with Th2 cells and identified genes enriched in mRNA processing and cell cycle regulation pathways. Functional validation through LRRC42 knockdown experiments revealed its critical involvement in promoting cell proliferation, migration, and invasion in HCC cell lines. Collectively, these findings emphasize LRRC42 as a promising therapeutic target for inhibiting HCC progression and suggest its pivotal role in modulating key cellular processes integral to HCC advancement. - Source: PubMed
Publication date: 2025/02/12
Huang RongfuYao JianfengLiu LeiLi HuaHuang Baoshan - Colorectal cancer is a prevalent malignancy with an increasing incidence worldwide. Leucine-rich repeat-containing protein 42 (LRRC42) is known to be dysregulated in tumor tissues, yet its role in colorectal cancer remains largely unexplored. Herein, the function of LRRC42 in colorectal cancer was investigated using clinical samples, cellular experiments, animal models, and multiple omics techniques. The results demonstrated that LRRC42 was highly expressed in colorectal cancer tissues and was associated with poor clinical outcomes. Silencing LRRC42 suppressed cell proliferation, induced G0/G1 phase arrest, and promoted apoptosis by reducing Bcl2 expression while elevating the expression of Bax, cleaved PARP and cleaved caspase 3. Conversely, LRRC42 overexpression exhibited the opposite effects. Consistent findings were observed in vivo. Additionally, ubiquitin specific peptidase 7 was identified as a potential LRRC42-interacting protein through immunoprecipitation-mass spectrometry, with ubiquitin specific peptidase 7 stabilizing LRRC42 expression by promoting its deubiquitination. Notably, LRRC42 overexpression partially reversed the effects of ubiquitin specific peptidase 7 silencing on tumor cell proliferation and apoptosis. mRNA sequencing analysis revealed that differentially expressed genes in LRRC42 overexpressing cells were linked to Wnt signaling pathway, suggesting that LRRC42 overexpression may activate this pathway. Furthermore, LRRC42 was proved to elevate the levels of ki67, cyclin D1 and WNT3, while reducing the level of p-β-catenin. These findings suggest that LRRC42 perhaps serve as a potential oncogenic factor in colorectal cancer, regulated by ubiquitin specific peptidase 7 and capable of activating Wnt/β-catenin signaling pathway. - Source: PubMed
Publication date: 2024/10/09
Li YunzeSun XinHuang Zhe - Alpaca (Vicugna pacos), llama (Lama glama), vicugna (Vicugna vicugna) and guanaco (Lama guanicoe), are the camelid species distributed over the Andean high-altitude grasslands, the Altiplano, and the Patagonian arid steppes. Despite the wide interest on these animals, most of the loci under selection are still unknown. Using whole-genome sequencing (WGS) data we investigated the occurrence and the distribution of Runs Of Homozygosity (ROHs) across the South American Camelids (SACs) genome to identify the genetic relationship between the four species and the potential signatures of selection. - Source: PubMed
Publication date: 2023/08/21
Pallotti StefanoPicciolini MatteoAntonini MarcoRenieri CarloNapolioni Valerio