AQP3 siRNA_Lentivectors
- Known as:
- AQP3 siRNA_Lentivectors
- Catalog number:
- i001203a
- Product Quantity:
- 500ng
- Category:
- -
- Supplier:
- ABM
- Gene target:
- AQP3 siRNA_Lentivectors
Related genes to: AQP3 siRNA_Lentivectors
- Gene:
- AQP3 NIH gene
- Name:
- aquaporin 3 (Gill blood group)
- Previous symbol:
- -
- Synonyms:
- GIL
- Chromosome:
- 9p13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1994-07-25
- Date modifiied:
- 2019-04-23
Related products to: AQP3 siRNA_Lentivectors
Related articles to: AQP3 siRNA_Lentivectors
- Dilated cardiomyopathy (DCM) is the most common non-ischemic cardiomyopathy and a major cause of heart failure, but disease-specific molecular biomarkers remain limited. This study aimed to identify and prioritize tissue-level, disease-responsive candidate biomarkers for DCM using an integrative multi-omics bioinformatics framework. - Source: PubMed
Publication date: 2026/06/09
Li JingweiSong ZhongyangWang GuanweiChen YuchanCheng JiamiaoZhang Zhiming - The ruminant colon plays a critical role in intestinal homeostasis but is highly susceptible to dysfunction induced by high-concentrate diets during the finishing period. This study investigated the efficacy of alkaline mineral complex (AMC) against such colonic disturbances in finishing cattle. - Source: PubMed
Publication date: 2026/06/02
Li JiaLiu XingyuGu LiLiu XiaowanWang YixinGuo HongruiGou LipingQi JianchengZuo Zhicai - Adolescent depression is a prevalent and serious mental health issue that can negatively impact multiple organ systems, including the cardiovascular system. This study investigates the effects of chronic unpredictable mild stress (CUMS), a validated animal model of depression, on the expression of Aquaporins (AQP1, AQP2 and AQP3) in the cardiac tissue of adolescent rats and evaluates the potential therapeutic role of ashwagandha (Withania somnifera (L.) Dunal). Twenty-eight male Wistar albino rats were divided into four groups: Control, CUMS, CUMS+SERT, and CUMS+ASHW. Treatments were administered via oral gavage for 28 days, and cardiac tissues were evaluated histologically, immunohistochemically and biochemically. While serum levels of CK, Na, Cl and K showed no significant differences across groups, histological examination revealed myocardial damage (edema, hemorrhage, vacuolization) in CUMS rats. Immunohistochemical analysis demonstrated strong AQP1 expression across all groups, while AQP2 and AQP3 showed increased expression in treatment groups compared to the control. These findings suggest that Ashwagandha may mitigate stress-induced cardiac changes and influence aquaporin expression, particularly AQP2 and AQP3, which could be relevant to cardiac water balance and function in depression. Further studies are warranted to explore the molecular mechanisms linking aquaporin modulation and cardioprotection in stress-related pathologies. - Source: PubMed
Publication date: 2026/06/15
Baksi NGokdemir G ŞArkaş Alklay AKarakoç Z - Constipation is a common gastrointestinal disorder, which impairs health and quality of life. This study evaluated the ameliorating effects and underlying mechanism of 6'-sialyllactose (6'-SL) and subsp. BB12 (BB12) on loperamide-induced constipation and associated depression-like behaviors. 6'-SL combined with BB12 increased the fecal water content, fecal pellet number, and gastrointestinal transit rate while reducing the time of first black feces. 6'-SL and BB12 modulated secretion of intestinal neurotransmitters, regulated expression of AQP3 and Claudin-1, and modulated expression of key proteins in the SCF/c-Kit pathway. Meanwhile, 6'-SL and BB12 ameliorated depression-like behaviors by inhibiting inflammatory responses and modulating the expression of synaptic plasticity-related proteins in the brain. Moreover, 6'-SL and BB12 regulated the diversity of gut microbiota, enhanced the relative abundance of and , and elevated SCFA levels. This study provides a theoretical and practical basis for developing functional foods based on synbiotics containing 6'-SL and BB12. - Source: PubMed
Publication date: 2026/06/15
Tian ZihaoTan ZhongmeiZhang XuguangXie QinggangSong MingjinChen XianhuiMa JiageRen Qiqi - Aquaporins (AQPs) are a family of water channel proteins with a significant role in immune cell function. Although aquaporins have been studied in sepsis, their expression in critical illness remains underexplored. Our group aimed to examine the mRNA expression profile of AQP isoforms in polymorphonuclear (PMN) and peripheral blood mononuclear cells (PBMCs) of critically ill patients admitted to the intensive care unit (ICU). To this end, we designed a prospective, longitudinal, observational study performed in the ICU of "Evangelismos" General Hospital between February 2024 and October 2024. In total, 40 critically ill patients and 25 healthy controls were enrolled in the study. Blood samples were collected at four time points: upon ICU admission (24-48h), and at days 4 (D4), 8 (D8), and 14 (D14). Total RNA was extracted from PMNs and PBMCs, and RT-qPCR was performed to examine mRNA levels of AQPs 1, 2, 3, 4, 5, 7, and 9. Our results revealed downregulation of AQP isoforms, except AQP1, in PMNs, whereas PBMCs exhibited sustained upregulation of all AQPs except AQP3, which was downregulated. Our findings suggest that differential AQP expression in immune cell subsets may reflect adaptive immune responses during critical illness, providing insights into leukocyte function and potential therapeutic targets. - Source: PubMed
Publication date: 2026/06/02
Lotsios Nikolaos SIssaris VasileiosPoupouzas GeorgiosVrettou Charikleia SKeskinidou ChrysiKardara MatinaPapavassiliou Kostas AEconomidou FoteiniKokkoris SteliosKotanidou AnastasiaDimopoulou IoannaVassiliou Alice G