C_REACTIVE PROTEIN, Human (CRP)
- Known as:
- C_REACTIVE PROTEIN, Human (CRP)
- Catalog number:
- 140-11
- Product Quantity:
- 2 mg
- Category:
- -
- Supplier:
- LeeBio
- Gene target:
- C_REACTIVE PROTEIN Human (CRP)
Related genes to: C_REACTIVE PROTEIN, Human (CRP)
- Gene:
- ABCG2 NIH gene
- Name:
- ATP binding cassette subfamily G member 2 (Junior blood group)
- Previous symbol:
- -
- Synonyms:
- EST157481, MXR, BCRP, ABCP, CD338
- Chromosome:
- 4q22.1
- Locus Type:
- gene with protein product
- Date approved:
- 1999-10-26
- Date modifiied:
- 2019-04-23
- Gene:
- ADIPOQ NIH gene
- Name:
- adiponectin, C1Q and collagen domain containing
- Previous symbol:
- ACDC
- Synonyms:
- ACRP30, AdipoQ, apM1, GBP28, adiponectin
- Chromosome:
- 3q27.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-26
- Date modifiied:
- 2016-10-05
- Gene:
- BANF1P1 NIH gene
- Name:
- barrier to autointegration factor 1 pseudogene 1
- Previous symbol:
- -
- Synonyms:
- BCRP1, D14S1460, D14S1460E, BCRG1
- Chromosome:
- 14q24.1
- Locus Type:
- pseudogene
- Date approved:
- 2003-04-09
- Date modifiied:
- 2012-04-19
- Gene:
- C1QTNF4 NIH gene
- Name:
- C1q and TNF related 4
- Previous symbol:
- -
- Synonyms:
- CTRP4, ZACRP4
- Chromosome:
- 11p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-02
- Date modifiied:
- 2017-03-01
- Gene:
- C1QTNF6 NIH gene
- Name:
- C1q and TNF related 6
- Previous symbol:
- -
- Synonyms:
- CTRP6, ZACRP6
- Chromosome:
- 22q12.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-02
- Date modifiied:
- 2017-03-01
Related products to: C_REACTIVE PROTEIN, Human (CRP)
Related articles to: C_REACTIVE PROTEIN, Human (CRP)
- Skin coloration is a distinctive phenotype and an economically important trait in ornamental fish. Understanding its regulatory mechanisms is crucial for both aquaculture and selective breeding. In this study, we cloned and analysed the full-length complementary DNA (cDNA) sequences of four key pigmentation-related genes-mitf, mc1r, tyr and sox10-in the black-tailed angelfish (Centropyge vrolikii). We established the fin-derived tissue cell line of C. vrolikii (CVFTCL) and confirmed its transfection efficiency using EGFP, achieving 40%-50% expression 24 h post-transfection, providing an in vitro platform for subsequent gene function verification. Using the primary fin cell culture system, we conducted overexpression and RNA interference (RNAi) experiments to investigate the regulatory relationships among these genes. Overexpression of mitf upregulated mc1r but downregulated sox10 and tyr; overexpression of mc1r enhanced mitf expression while inhibiting sox10 and tyr; overexpression of tyr only increased tyrp1 expression and overexpression of sox10 upregulated both mc1r and mitf, without affecting tyr. RNAi-mediated knockdown confirmed the efficiency of gene silencing and supported the regulatory relationships inferred from overexpression experiments. Collectively, these findings indicate that mitf, mc1r, tyr and sox10 may interact to coregulate melanocyte development and melanin synthesis, thereby influencing skin coloration in C. vrolikii. This study provides a mechanistic framework for pigmentation regulation and a foundation for colour improvement and selective breeding in this species. - Source: PubMed
Publication date: 2026/05/28
Luo DingyuanXi NingShi ShengkaiLu YizhenChen ZebinLiu HongweiChen JincanHuang HaiZhong ZhaoweiJiang Yonghua - Coat colour is among the most distinctive phenotypic traits for pig breed identification. Zhaotong pigs (ZTs), indigenous pigs in China, present two coat colour types: black and brown. However, the key genes and regulatory mechanisms responsible for coat colour variation remain unknown. In this study, we analysed the whole-genome resequencing data of 1110 individuals, including 43 pig breeds, Eurasian wild boars, and an outgroup. Population genetic structure analysis, including principal component analysis (PCA), phylogenetic tree construction, and admixture analysis, revealed that ZTs present unique genetic characteristics. Using selective sweep analysis of the black population vs brown population of ZTs and a genome-wide association study (GWAS) targeting coat colour, we identified tyrosinase-related protein 1 (TYRP1) and nuclear factor I B (NFIB) as two important functional genes that influence coat colour in ZTs. A mutation at the g.209726926_209726931del locus in exon 8 of the TYRP1 gene results in decreased eumelanin synthesis, leading to the brown coat colour of ZTs. Our study is the first to systematically elucidate the molecular genetic mechanisms underlying coat colour formation in ZTs, providing essential theoretical foundations for the conservation of indigenous pig genetic resources and the development of new specialized breeds. - Source: PubMed
Publication date: 2026/05/25
Zhou ChunluLi XinpengDong WenjunWang LixingChu JinyuChong YuqingMa YunlongDong XinxingYan Dawei - Alternations of DNA methylation occur in aging, which is regulated by DNA methyltransferases (DNMTs). In this study, we show that even though the transcription of DNMT1, the only enzyme that maintains DNA methylation in the mammalian genome, is reported to be decreased in an age-dependent manner, the decrease of mRNA does not result in a decrease of its protein. Instead, DNMT1 protein is increased in aged mouse tissues, which is responsible for the methylation of genes related to macroautophagy/autophagy, senescence repression, and melanin synthesis and transport in aged organs, resulting in a decline of autophagy, an increase of senescence in those organs, and a decrease in melanin production in hair follicles (canities) in response to ionizing radiation (IR). Genetic deletion and inhibition of DNMT1 can reverse these processes. The interaction of DNMT1 with ATG7 through its CXXC domain is essential for its degradation, and treatment with senolytics also downregulates DNMT1 in aged organs, supporting two feedback loops between them.: 4-OHT, 4-hydroxytamoxifen; ChIP, chromatinimmunoprecipitation; D, dasatinib; D-gal, D-galactose; DCT/Trp-2, dopachrometautomerase; DMRs, differentially methylated regions; DNAm, DNA methylation; DNMTs,DNA methyltransferases; DSBs, double-stranded breaks; ETO, etoposide; GST, glutathione-S-transferase; HEK293T,human embryonic kidney 293T; HEM, human epidermal melanocytes; Hydr, hydralazine;IP, immunoprecipitation; IR, ionizingradiation; KIF1A, kinesin family member 1A; M, methylated; MmIMCD3,mouse inner-medullary collecting duct 3; MITF, melanocyte inducingtranscription factor; MSP, methylation specific PCR; NCBI, national center for biotechnologyinformation; N-me, N-methyladenosine; PBMCs, peripheral blood mononuclear cells;Pro, proliferating; Q, quercetin; Rapa, rapamycin; RRBS, reduced representationbisulfite sequencing; RT, reverse transcription; SA-GLB1/β-Gal, senescence-associatedgalactosidase beta 1; SASP, senescence-associated secretory phenotype; Sen, senescent; SNP, single nucleotidepolymorphism; TYR, tyrosinase; TYRP1/Trp-1, tyrosinase related protein 1; UHRF1,ubiquitin like with PHD and ring finger domains 1; UM, unmethylated; UTR, untranslatedregion; WGBS, whole-genome bisulfite sequencing. - Source: PubMed
Publication date: 2026/05/28
Li LuMao XinyueLi Linda XiaoyanXiao HuapingLou ZhenkunLiu HongboZhou Julie XiaYao LiLi Xiaogang - Although PD-1 inhibitors have significantly reduced metastatic melanoma patients' mortality, only a small proportion of these patients actually benefit. We aim to develop some parsimonious predictive models for identifying those patients' survival outcome under anti-PD-1 treatment. - Source: PubMed
Publication date: 2026/05/18
Wang YuTang WeiWang YuanyuanLu XiaoyuZhang LingYang JiaojiaoYang ShuibingYang Jingjin - In the cosmetic industry, active ingredients often consist of organic compounds that are hydrophobic, making oil-based formulations impractical. Oil-in-water (O/W) nanoemulsions are used to deliver such ingredients in an aqueous medium. However, creating stable nanoemulsions with uniform size, especially from natural products, poses significant challenges. This study presents the development of micellar O/W nanoemulsions to deliver meroterpenoid-rich fractions from the ethanolic extract of (MES). We systematically investigated the effects of mixing order and chemical compositions on the size and stability of nanoemulsions, enhancing stability with a tri-block copolymer for micellar features. Under optimised conditions, nanoemulsions with a size around 20 nm were prepared. The MES-loaded nanoemulsion effectively inhibited melanin production over multiple cycles, demonstrating increased stability against oxidation. Molecular docking revealed strong binding affinities of MES compounds to tyrosinase-related protein 1 (TYRP1), indicating potential as effective skin-whitening agents. - Source: PubMed
Publication date: 2024/12/30
Siboro Sonita A PSalma Sabrina AufarYuliati FritaRahayu Iresha MuthiaTaek Lim Kwon