ACOT4 siRNA_Lentivectors
- Known as:
- ACOT4 siRNA_Lentivectors
- Catalog number:
- i000411c
- Product Quantity:
- 500ng
- Category:
- -
- Supplier:
- ABM
- Gene target:
- ACOT4 siRNA_Lentivectors
Related genes to: ACOT4 siRNA_Lentivectors
- Gene:
- ACOT4 NIH gene
- Name:
- acyl-CoA thioesterase 4
- Previous symbol:
- -
- Synonyms:
- FLJ31235, PTE-Ib, PTE2B
- Chromosome:
- 14q24.3
- Locus Type:
- gene with protein product
- Date approved:
- 2005-09-08
- Date modifiied:
- 2016-10-05
Related products to: ACOT4 siRNA_Lentivectors
Related articles to: ACOT4 siRNA_Lentivectors
- Gestational diabetes mellitus (GDM) poses significant health risks, yet the causal genetic and epigenetic mechanisms linking glycolipid metabolism dysregulation to GDM remain elusive. This study aimed to identify key causal genes and regulatory pathways by integrating multi-omics data with large-scale genetic association studies. - Source: PubMed
Publication date: 2026/05/20
Lin XiaoxiaoZheng JingjingQin NingningLi Yimei - Cholesterol imbalances and elevated blood pressure (BP) are closely interrelated risk factors for cardiovascular disease (CVD) and are subject to genetic influences. We sought to identify novel associations between candidate genetic coding variants and CVD traits in our isolated study cohort and validate them in a general population cohort. - Source: PubMed
Publication date: 2026/02/09
Meyjes-Brown Jacob W ISutherland Heidi GTran Kim NganBenton Miles CLea Rod AGriffiths Lyn R - Psoralea corylifolia(PF) is widely utilized for the treatment of conditions such as kidney yang deficiency, frequent urination, and cold pain in the waist and knees. However, both basic research and clinical reports indicate that it induce hepatotoxicity. Our preliminary research has confirmed that PF has hepatotoxicity and in vitro research indicated that psoralidin is hepatotoxic. but it remains unclear whether psoralidin is the hepatotoxic component of PF and the mechanism of psoralidin induces hepatotoxicity. This study aimed to investigate the hepatotoxicity induced by psoralidin and its toxic mechanisms. - Source: PubMed
Publication date: 2026/02/02
Guo ZhaojuanPeng XiyiQin DashengZhang LinTu CanWang Ting - PURPOSE: Oncogenesis and tumor progression have been linked to abnormal metabolism. We aimed to investigate the potential connection between sulfur metabolism-related genes and clinical features of patients with breast cancer. METHODS: Machine learning algorithms were utilized to assess the risk index of sulfur metabolism-related genes in breast cancer. All patients were categorized into high- and low-risk clusters, based on their calculated average risk scores. Kaplan–Meier curves were used to evaluate the patient prognoses in different groups. Enrichment analysis was performed on the differentially expressed genes (DEGs) across these distinct clusters. The effect of the highest-risk gene, HSPA9, on the malignant behavior of tumor cells was appraised through siRNA transfection. RESULTS: A risk model with nine sulfur metabolism-related genes (ACOT2, ACOT4, CHPF, ELOVL2, HLCS, HSPA9, MICAL1, SPOCK2, and TCF7L2) was established, and low-risk groups exhibited better outcomes than high-risk groups. Various biological functions and pathways of the DEGs were observed between the different groups. The high-risk group exhibited a higher immune cell infiltration rate than the low-risk group. Inhibiting HSPA9 expression effectively reduced breast cancer cell proliferation and migration. CONCLUSION: Our genetic risk model provides a novel pattern for prognostic evaluations and individualized therapeutic strategies for breast cancer. Given its association with breast cancer risk, HSPA9 represents an exceptionally promising therapeutic target. - Source: PubMed
Publication date: 2026/01/16
Yuan YuanZhang ShuyaoFu JialeiZhou Fei - Cervical cancer, in which cervical squamous cell carcinoma (CSCC) accounts for 60-70% of cases, has a poor prognosis and poses a significant health threat to global patients. Lipid metabolism reprogramming is a key driver of tumor progression and tumor microenvironment (TME) regulation, making it a promising target for improving the efficacy of immunotherapy. This study aimed to construct a lipid metabolism prognostic signature (LMPS) in CSCC and identify key genes involved in tumor progression. - Source: PubMed
Publication date: 2025/10/14
Bai GaigaiChen FanghuaQiu JunjunHua Keqin