VALPROIC ACID (VALPROATE), SERUM
- Known as:
- VALPROIC ACID (VALPROATE), SERUM
- Catalog number:
- 1244
- Product Quantity:
- 1
- Category:
- -
- Supplier:
- Kenova
- Gene target:
- VALPROIC ACID (VALPROATE) SERUM
Related genes to: VALPROIC ACID (VALPROATE), SERUM
- Gene:
- MED25 NIH gene
- Name:
- mediator complex subunit 25
- Previous symbol:
- -
- Synonyms:
- ARC92, ACID1, TCBAP0758, DKFZp434K0512
- Chromosome:
- 19q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 2004-11-09
- Date modifiied:
- 2019-04-23
Related products to: VALPROIC ACID (VALPROATE), SERUM
Related articles to: VALPROIC ACID (VALPROATE), SERUM
- The Thr445Met substitution in the novel allele med25-5 uncouples seed dormancy from flowering, and MED25 acts as a negative regulator of seed dormancy via the DOG1 and ABA pathways. MED25, a pivotal subunit of the Mediator complex, regulates diverse biological processes, but its role in seed dormancy remains unclear. Here, we identified a novel MED25 allele, med25-5, harboring a Thr445Met substitution in the MD domain, which enhances seed dormancy without affecting flowering time in Arabidopsis thaliana. The med25-5 mutant exhibited increased dormancy with altered expressions in DOG1 and ABA signaling genes (e.g., ABI1, NHL6) and increased sensitivity to ABA and PAC. Either dog1-3 or abi3-10 can completely repress the enhanced seed dormancy of med25, indicating MED25 regulates dormancy requiring the DOG1 and ABA pathways. The Thr445 residue is conserved across crops, highlighting MED25's potential for crop improvement against pre-harvest sprouting. Our study uncovers MED25 as a negative regulator of seed dormancy, providing insights into the molecular mechanisms coordinating dormancy and flowering. - Source: PubMed
Publication date: 2026/07/02
Yang YueLi Xiao-YingDing RunCao HongLiu YongxiuLi Yu - To explore the clinical features and genetic etiology of a child with Basel-Vanagaite-Smirin-Yosef syndrome (BVSYS). - Source: PubMed
Zhao YongLi NuoHan YuLi NannanLiu QiuliFu WenjieLuo GuanjunChen YizhaoWang NantianZhou YuanQian Xuguang - ABSCISIC ACID INSENSITIVE 5 (ABI5) is a key regulator that represses seed germination, flowering, and seedling growth in and functions in abscisic acid (ABA) signal transduction. However, whether ABI5 is involved in other biological processes and its interacting partners remain largely unknown. Here, we show that , an ortholog of , positively regulates erucic acid synthesis and the transcript level of the marker gene in . Expression patterns of and overlap during specific stages of seed development, as indicated by the BnIR database, and GUS staining assays show that both genes are expressed in seeds. BnaABI5 is a bZIP transcription factor that localizes to the nucleus and activates transcription of the reporter gene . We further demonstrate that the mediator subunit BnaMED25 is involved in modulating erucic acid synthesis through interaction with BnaABI5 and . Dual-luciferase assays and electrophoretic mobility shift assays (EMSAs) indicate that BnaMED25 facilitates BnaABI5-mediated regulation of expression. Genetic experiments indicate that, compared with wild-type Col-0 and the variety "Wangxiangyou1881", the transcript level of the marker gene is increased in -overexpressing and oilseed rape, respectively. Erucic acid content in the tested seeds exhibited a corresponding trend. Taken together, these results demonstrate that BnaMED25 is involved in BnaABI5-mediated regulation of erucic acid accumulation and reveal a mechanism by which ABI5 and its recruiting factor play a significant role in long-chain fatty acid synthesis. - Source: PubMed
Publication date: 2026/06/10
Li ZhuangZhi ShouchuanTang YongkangLi HuanTian MengliangPu XiaobinWu Yongcheng - HO functions as a signaling molecule regulating plant growth, development, and stress responses; however, its role in jasmonic acid (JA) signaling transduction and JA-regulated biological processes remains elusive. Here, we report that General regulatory factor 8 (GRF8) is a critical factor inhibiting JA signaling, while HO removes this inhibition to facilitate the JA response during root growth and leaf senescence in Arabidopsis. GRF8 interacts with and inhibits MYC2, the key transcription factor in JA signaling. It recruits Jasmonate-ZIM domain (JAZ) repressors to enhance their interaction with and inhibition of MYC2. Additionally, GRF8 competes with Mediator 25 (MED25), a subunit of the Mediator coactivator complex, to interact with MYC2. Upon increased JA levels, HO sulfenylates GRF8 at cysteine-103, reducing its interaction with MYC2 and thereby releasing MYC2 activity to stimulate the JA response. Together, our findings suggest that HO-mediated sulfenylation of GRF8 provides a redox-based mechanism to modulate JA signaling in Arabidopsis. - Source: PubMed
Publication date: 2026/05/29
Song Ru-FengLi LinGuo Xin-RuLiao Cai-YiLiu Wen-Cheng - DNA methylation has been proposed as a predictive biomarker. Cervical intraepithelial neoplasia grade 2 (CIN2) was historically the cut-off for surgical treatment, however it is increasingly managed with active surveillance, while there is currently no accurate way to predict which lesions will regress. - Source: PubMed
Publication date: 2026/04/11
Ellis Laura BurneyBowden Sarah JParaskevaidi MariaLyons DeirdreParaskevaidis EvangelosMoscicki Anna-BarbaraFlanagan James MKyrgiou Maria