GLI1 Antibody
- Known as:
- GLI1 Antibody
- Catalog number:
- Y214004
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- GLI1 Antibody
Related genes to: GLI1 Antibody
- Gene:
- GLI1 NIH gene
- Name:
- GLI family zinc finger 1
- Previous symbol:
- GLI
- Synonyms:
- -
- Chromosome:
- 12q13.3
- Locus Type:
- gene with protein product
- Date approved:
- 1986-01-01
- Date modifiied:
- 2016-01-15
Related products to: GLI1 Antibody
Related articles to: GLI1 Antibody
- Lung organogenesis is orchestrated by dynamic epithelial-mesenchymal interactions during embryogenesis, yet the gene regulatory programs and signaling dynamics governing these processes in the pseudoglandular stage remain incompletely understood. In this study, we integrated spatial and single-cell transcriptomic data across embryonic developmental stages to systematically characterize epithelial and mesenchymal dynamics during lung development. To achieve more refined cell types at single-cell resolution in spatial transcriptomic data, we developed a bin-based deconvolution strategy that enabled high-precision cell-type assignment. We subsequently constructed a 3D spatiotemporal landscape of lung development and elucidated the molecular regulatory mechanisms underlying epithelial-mesenchymal maturation during lung morphogenesis. In addition, we analyzed transcription factor module activity, intercellular communication signaling, and predicted downstream target genes, while integrating public GWAS metadata to link developmental programs with lung cancer-related features. We observed pronounced stage-specific functional heterogeneity between the pseudoglandular and late embryonic stages. Notably, E13.5 emerged as a critical transition window, during which progenitor states shifted toward more mature cellular phenotypes. We reconstructed epithelial-mesenchymal interactions and uncovered coordinated rewiring of ligand-receptor signaling and transcriptional networks across developmental stages. Regulatory network analysis further identified temporally coordinated transcription factor modules centered on , , , , , and , which collectively orchestrated branching morphogenesis, epithelial patterning, and tissue stabilization. Integration with lung cancer genome-wide association data demonstrated that embryonic lung progenitor states exhibit strong associations with lung cancer-related transcriptional programs, particularly involving epithelial-mesenchymal plasticity and RNA-splicing pathways. Furthermore, TP53/HNRNP-mutant lung adenocarcinomas displayed embryonic-like molecular features associated with cytoskeletal remodeling and progenitor-state reactivation. Together, our study provided a spatiotemporally resolved framework of embryonic lung development and identifies a critical transition window linking lung morphogenesis, regulatory network remodeling, and cancer-associated epithelial plasticity. - Source: PubMed
Publication date: 2026/06/01
Zheng HuiwenLin JinpeiLi HanyiHao ShijieCheng Mengnan - The Hedgehog (Hh) signaling pathway plays an essential role in tissue development and homeostasis.Glioma-associated oncogene homolog 1 (Gli1) functions as a key transcription factor in Hedgehog signaling and acts as a direct target gene within this pathway. Gli1-positive (Gli1) cells functions as pivotal effector cells of the Hh pathway, and play complex and critical roles in oral tissue development, homeostasis, post-injury repair, and oral disease progression. Recent advances in lineage-tracing techniques and single-cell RNA sequencing have deepened our understanding of Gli1 cells, evolving from simple Hh pathway effectors to heterogeneous mesenchymal stem cell subsets, significantly enriching our knowledge of oral biology and pathology. This review systematically summarizes the fundamental characteristics of Gli1 cells and their function in oral tissues.Their contributions to the initiation and progression of oral diseases, and the latest advances in Gli1 cell-based tissue regeneration and disease treatment are also discussed. By integrating our findings on the biological properties of Gli1 cells into their immunomodulatory roles in disease and Gli1 cell-centered tissue regeneration strategies, we aim to provide a theoretical foundation for elucidating the cellular and molecular mechanisms that maintain oral tissue homeostasis. These insights pave the way for novel and precise therapeutic approaches in oral regenerative medicine. - Source: PubMed
Publication date: 2026/06/20
Xiao LiAi MiWu LaidiYu YilinCao YingguangSong Ke - - Source: PubMed
Publication date: 2026/06/04
Wolfram ChristopherMcAlpine Cameron S - To investigate the role and epigenetic mechanism of methyltransferase 14 (METTL14)-mediated N6-adenylate methylation (m6A) modification of long non-coding RNAs (lncRNAs) in the pathogenesis of periodontitis. - Source: PubMed
Publication date: 2026/06/17
Du JuanCheng Zi'angZhang YuCong YaqiGuo DonghuaZhou YiHuang Jing - Diagnosing low-grade spindle cell lesions of the skin can be challenging. In particular, distinguishing among fibroblastic, myofibroblastic, and smooth muscle or pericytic proliferations may be difficult during a routine histologic examination. This article provides an update on recent developments in superficial mesenchymal tumors exhibiting smooth muscle and pericytic differentiation. We focus on the characterization of clinicopathological features, differential diagnosis, and recurrent molecular alterations. Additionally, we address superficial leiomyosarcomas, which are now classified as atypical intradermal smooth muscle neoplasms due to their low risk of aggressive behavior. The article also discusses Epstein-Barr virus-associated smooth muscle tumors. - Source: PubMed
Publication date: 2026/06/16
Machado IsidroParafioriti AntoninaArmiraglio ElisabettaPadilla-Esquivel Jaime JoséSuarez Natalia RojoTraves VíctorLlombart Beatriz