GATA3 Antibody
- Known as:
- GATA3 Antibody
- Catalog number:
- Y212708
- Product Quantity:
- 200ul
- Category:
- -
- Supplier:
- ABM
- Gene target:
- GATA3 Antibody
Related genes to: GATA3 Antibody
- Gene:
- GATA3 NIH gene
- Name:
- GATA binding protein 3
- Previous symbol:
- -
- Synonyms:
- HDR
- Chromosome:
- 10p14
- Locus Type:
- gene with protein product
- Date approved:
- 1992-11-03
- Date modifiied:
- 2016-10-05
Related products to: GATA3 Antibody
Related articles to: GATA3 Antibody
- GATA-binding protein 3 (GATA3) is a pivotal transcriptional regulator during mammary gland development and serves as a core biomarker in breast cancer. Although traditionally recognized for maintaining luminal differentiation, its high mutation frequency reveals a complex, dual role in tumorigenesis. - Source: PubMed
Publication date: 2026/09/01
Tan JunjuanChen WeihanSong KaiyanZhu XiaoqianHong LiweiZhou JujuChen KaiLv Haitong - Aging leads to structural changes in facial adipose tissue, characterized by an imbalance between adipocyte regeneration and hypertrophy. Current therapeutic approaches primarily target individual aspects of these changes, often failing to address the dual nature of facial adipose remodeling. Using a combination of in vivo and ex vivo methods, we present a therapeutic strategy based on root extract (KPRE) rich in polymethoxyflavonoids. Mechanistically, we demonstrate that KPRE sustains preadipocyte proliferation while reducing hypertrophy in mature adipocytes via activation of the transcriptional regulators SOX9 and GATA3 while suppressing PPARγ and SREBP1. To translate these findings toward human application, we conducted a clinical pilot study in 35 participants with topical application of KPRE long-chain fatty acid emulsions for 6 months. By comparing high-resolution stereoscopic imaging and digital 3-dimensional modeling data at baseline and after 3 months and 6 months of follow-up, we show significant volume restoration in atrophic regions and reduction in hypertrophic areas, consistent with the coordinated effects observed in the organotypic adipose culture models. These findings provide a successful example for the rapid translation of molecular insights gained from organotypic human tissue models to human application and provide clinical evidence supporting the potential of KPRE-based formulations for facial adipose tissue rejuvenation. - Source: PubMed
Publication date: 2026/09/14
Taebnia NayereMurawska MagdalenaKemas Aurino MSheng HongdaWang YiXu JianZhou TingtingGalanin IvanLauschke Volker M - Severe skeletal muscle injury is a serious disease worldwide, but current clinical treatments are unsatisfactory because of the limited ability of these treatments to repair muscle; thus, novel therapies that can efficiently promote muscle regeneration are desirable. - Source: PubMed
Publication date: 2026/09/09
Zhang PeiwenXu YahongZhang YimengYang JingLiu ShuyunYuan YujiaChen YounanLi ChunhongLu YanrongWang HuiLiu Jingping - Neuroblastoma (NB) is a heterogeneous pediatric malignancy in which many high-risk tumors lack MYCN amplification, necessitating the identification of alternative molecular drivers. Here, integrative transcriptomic analyses of MYCN-nonamplified NB cohorts identified cell division cycle 20 (CDC20) as a candidate associated with high-risk disease and metastasis. CDC20 expression was elevated in aggressive NB across subtypes and correlated with adverse clinical outcomes, with particularly informative prognostic value in MYCN-nonamplified patients. Functional studies established CDC20 as a potent oncogene promoting proliferation, migration, apoptosis resistance, and tumor progression in NB models irrespective of MYCN status. Pharmacological inhibition of CDC20further supported CDC20 as a potential therapeutic vulnerability in NB. Mechanistically, we found that the transcription factor GATA3 directly bound a specific motif within the CDC20 promoter, as validated by ChIP-qPCR and site-directed point mutagenesis, and transcriptionally activates its expression. Reciprocal genetic epistasis experiments further demonstrated that CDC20 depletion attenuated GATA3-driven oncogenic phenotypes, whereas restoration of CDC20 rescued the impaired growth, migration, and survival caused by GATA3 depletion. At the downstream level, CDC20 facilitates NB progression via dual mechanisms: suppressing the pro-apoptotic Bax/Bcl-2 ratio and inducing an epithelial-mesenchymal transition-like phenotype conducive to metastasis. Collectively, our study delineates a previously uncharacterized GATA3-CDC20 regulatory axis that promotes NB progression and identify CDC20 as a potential therapeutic vulnerability across NB subtypes, while highlighting its particular potential for risk stratification in MYCN-nonamplified disease. - Source: PubMed
Publication date: 2026/09/11
Fang XiaonaLan YingxiaLi MengzhenXie WeijiMao LeiHuang JinlinLi QiutingZhang YuSong MengjiaQue YiLu SuyingWang JuanHuang JuntingZhu JiaWang YiSun FeifeiZhang Yizhuo - Ascariasis is a prevalent parasitic infection in both humans and pigs, resulting in significant human morbidity and economic losses in the porcine industry. Experimental infections are often studied by mimicking natural settings, exposing the host to frequent, small doses (trickle infection) or by administering a single (bolus) dose of infective eggs. However, the impact of infection schemes and doses on the host immune response inA. suum infected pigs is still unclear. Using trickle and bolus infections and applying different doses, we found systemic GATA3+CD4+ T cells and eosinophils increased dose-dependently during A. suum body migration, while CD4+ T cells that specifically recognize A. suum antigens showed no association with the infection dose. In contrast, all dose-dependent differences were resolved by 8-9 weeks post infection, when adult worms were present. The results further showed that adult worm burden did not differ detectably across all groups, though a high intragroup variability was observed. Local type 2, germinal center B cell, and Tfh cell responses were dose-dependent in bolus infected animals only. Our data suggest that the initial immune response generated during A. suum larval migration is pivotal in determining the fate of the antiparasite response and adult worm population. Moreover, our results indicate that the host can regulate the worm load independent of the infection dose and scheme. - Source: PubMed
Oser LarissaRoose SaraMidha AnkurSchlosser-Brandenburg JosephineLaubschat AlexandraMusimbi Zaneta DKundik ArkadiHöfler PhilippHelm Christina Svon Samson-Himmelstjerna GeorgGeldhof PeterHartmann SusanneEbner Friederike