NK3R (Neurokinin 3 Receptor) Antibody
- Known as:
- NK3R (Neurokinin 3 Receptor) Antibody
- Catalog number:
- 20061
- Product Quantity:
- 100 µL
- Category:
- -
- Supplier:
- Immunostar
- Gene target:
- NK3R (Neurokinin 3 Receptor) Antibody
Related genes to: NK3R (Neurokinin 3 Receptor) Antibody
- Gene:
- TACR3 NIH gene
- Name:
- tachykinin receptor 3
- Previous symbol:
- -
- Synonyms:
- NK3R, NKR, TAC3R, NK3
- Chromosome:
- 4q24
- Locus Type:
- gene with protein product
- Date approved:
- 1997-11-28
- Date modifiied:
- 2018-02-28
Related products to: NK3R (Neurokinin 3 Receptor) Antibody
Related articles to: NK3R (Neurokinin 3 Receptor) Antibody
- Enteric glia are key components of the nervous system, contributing to many aspects of gastrointestinal function. In this issue of Neuron, Muppirala and colleagues reveal that anatomical niches dictate enteric glial transcriptional identity, identifying Tacr3 as a specific marker for intraganglionic glia. - Source: PubMed
Rowland Eve SStamp Lincon AHao Marlene M - Little is known about the regulation of gene expression related to the hypothalamus-pituitary (HP) axis around the onset of normal puberty. In the present study, we examined the expression profiles of genes in HP hormone circuit on every other day from postnatal day (PND) 29 to PND 43. Average vaginal opening (VO) date was PND 37 (66%), and the weight of reproductive organs increased significantly from PND 37. Serum steroid hormone levels significantly increased on PND 39. The appearance of a number of Graafian follicles and corpora lutea on PND 37. Generally, our polymerase chain reactions (PCR) results showed that most of the expression of hypothalamus and pituitary factors tended to increase after VO, and the patterns were rather unstable and no significant peak pattern such as LH surge shown in proestrus adults. The mRNA levels of gonadotropin-inhibitory hormone (GnIH)-GPR147 and neurokinin B(Tac)-TacR3 mostly reached a peak in the last period of the experimental schedule. In pituitary, mRNA level of gonadotropin subunits (Cgα, LH-β and FSH-β) also significantly increased on later experimental period. In conclusion, we could confirm the rapid growth and maturation of reproductive organs immediately after VO, and dynamic changes in gene expression of the HP axis factors. The gene expression patterns at peripubertal period were incomplete and unstable without showing the preovulatory LH surge-related gene expression pattern in adults. The present study on neuroendocrine control of peripubertal sexual maturation may offer a basis for understanding normo- and/or patho-physiological status of puberty. - Source: PubMed
Publication date: 2025/12/31
Jeon Eun-YoungLee Sung-Ho - One of the largest glial populations outside the brain is in the gut. These enteric glia are involved in many functions, from intestinal peristalsis to immunity, yet it is unclear whether subtypes exist with distinct roles in homeostasis. Comparing glia from divergent microenvironments in the mouse intestine, we found that mucosal glia most resembled microglia, while muscularis glia resembled satellite glia. Tacr3, encoding the receptor for neuropeptide neurokinin B (NKB), was enriched within muscularis glia associated with neuronal soma and was undetectable in extraintestinal glia. Genetic or pharmacological manipulation of NKB-TACR3 signaling disrupted the establishment of enteric glial populations during postnatal development and dynamically modulated intestinal motor behaviors in adult mice. Collectively, we delineate spatially, transcriptionally, and functionally distinct populations of enteric glia; identify one as an unanticipated target of TACR3 antagonists in clinical use; and establish this pathway as necessary for enteric glial diversification and function. - Source: PubMed
Publication date: 2026/01/08
Muppirala Anoohya NMitchell Perry ECourtney EliseDebnath SushmitaD'Alessandro Lia RMani NehaDadabhoy MaryamRobinson ArielDíaz-Muñoz CristianParaskevopoulou Maria DD'Amato MauroGould Thomas WRao Meenakshi - Most women experience hot flashes (hot flushes) during the menopause transition. Menopausal hot flashes typically persist for years, and for a sizeable minority of women, are substantially impairing. Genetic investigations can improve understanding of hot flash etiology. - Source: PubMed
Publication date: 2026/01/06
Werwath Kathryn ELawn Rebecca BSalem Madeleine TLi TaydenMitchell Brittany LShen HanyangGordon Scott DKung BensonStafford CieraVemuri MytileeRatanatharathorn AndrewMeijsen JoeriShadyab Aladdin HKooperberg CharlesKoenen Karestan CCrandall Carolyn JMartin Nicholas GDuncan Laramie E - Endometriosis is a chronic, estrogen-driven inflammatory disorder affecting approximately 10% of reproductive-aged women globally. Despite increasing genomic insights into advanced-stage disease, the genetic underpinnings of early-stage endometriosis remain poorly understood, limiting opportunities for timely diagnosis and intervention. This study explores the contribution of regulatory variants, including those derived from ancient hominin introgression, and their interaction with modern environmental exposures in shaping endometriosis susceptibility. We conducted a dual-phase literature review to identify genes implicated in endometriosis pathophysiology and endocrine-disrupting chemical (EDC) sensitivity. Five genes (IL-6, CNR1, IDO1, TACR3, and KISS1R) were selected based on tissue expression, pathway involvement, and EDC reactivity. Whole-genome sequencing (WGS) data from the Genomics England 100,000 Genomes Project were analysed in nineteen females with clinically confirmed endometriosis. Variant enrichment, co-localisation, and linkage disequilibrium analyses were conducted, and functional impact was evaluated using public regulatory databases. Six regulatory variants were significantly enriched in the endometriosis cohort compared to matched controls and the general Genomics England population. Notably, co-localised IL-6 variants rs2069840 and rs34880821-located at a Neandertal-derived methylation site-demonstrated strong linkage disequilibrium and potential immune dysregulation. Variants in CNR1 and IDO1, some of Denisovan origin, also showed significant associations. Several of these variants overlapped EDC-responsive regulatory regions, suggesting gene-environment interactions may exacerbate risk. These findings propose a novel perspective of endometriosis susceptibility, in which ancient regulatory variants and contemporary environmental exposures converge to modulate immune and inflammatory responses. This integrative approach identified new potential biomarkers for early-stage detection of endometriosis. - Source: PubMed
Publication date: 2025/11/20
Warren AmeliaAndreou DemetraWarren DeanWieland JackMantzouratou Anna