IGFBP_1 (pp12)
- Known as:
- IGFBP_1 (pp12)
- Catalog number:
- 4I52
- Product Quantity:
- 1mg
- Category:
- -
- Supplier:
- Hytest
- Gene target:
- IGFBP_1 (pp12)
Related genes to: IGFBP_1 (pp12)
- Gene:
- CCN1 NIH gene
- Name:
- cellular communication network factor 1
- Previous symbol:
- IGFBP10, CYR61
- Synonyms:
- GIG1
- Chromosome:
- 1p22.3
- Locus Type:
- gene with protein product
- Date approved:
- 1998-03-02
- Date modifiied:
- 2018-10-11
- Gene:
- IGFBP1 NIH gene
- Name:
- insulin like growth factor binding protein 1
- Previous symbol:
- IBP1
- Synonyms:
- IGF-BP25, AFBP, hIGFBP-1, PP12
- Chromosome:
- 7p12.3
- Locus Type:
- gene with protein product
- Date approved:
- 1988-11-30
- Date modifiied:
- 2015-11-12
- Gene:
- NEK4 NIH gene
- Name:
- NIMA related kinase 4
- Previous symbol:
- STK2
- Synonyms:
- NRK2, pp12301
- Chromosome:
- 3p21.1
- Locus Type:
- gene with protein product
- Date approved:
- 1995-05-10
- Date modifiied:
- 2016-01-13
Related products to: IGFBP_1 (pp12)
3CH61,CCN family member 1,Ccn1,Cyr61,Cysteine-rich angiogenic inducer 61,IBP-10,IGF-binding protein 10,Igfbp10,IGFBP-10,Insulin-like growth factor-binding protein 10,Mouse,Mus musculus,Protein CYR61Anti-bovine Insulin Like Growth Factor Binding Protein-2 (IGFBP-2) antiserumAnti-Human Insulin Like Growth Factor Binding Protein-1 (IGFBP-1) protein antiserumAnti-Human Insulin Like Growth Factor Binding Protein-3 (IGFBP-3) antiserumAnti-Human Insulin Like Growth Factor Binding Protein-4 (IGFBP-4) protein antiserumAnti-Human Insulin Like Growth Factor Binding Protein-5 (IGFBP-5) protein antiserumAnti-Human Insulin Like Growth Factor Binding Protein-7 (IGFBP-7) protein IgG, aff pureAnti-Insulin-like Growth Factor Binding Protein-1 (IGFBP-1 (pp12)) AntibodyAnti-Insulin-like Growth Factor Binding Protein-1 IGFBP-1 pp12 antibodyAntigens IGFBP-4Antigens Insulin like growth factor binding protein-1 (IGFBP-1)Anti_Insulin_like Growth Factor Binding Protein_1 (IGFBP_1 (pp12))Biochemical: IGFBP-3, human recombinantBovine IGFBP-2Bovine IGFBP-2 Related articles to: IGFBP_1 (pp12)
- Preterm birth (PTB) is a major cause of neonatal morbidity and mortality, with vaginal microbiome dysbiosis and local immune responses implicated in its pathogenesis. However, the role of vaginal immune and extracellular matrix (ECM) remodeling factors in the progression from preterm labor (PTL) to PTB remains unclear. This study examines the associations between microbiome composition and immune and ECM-related protein composition in PTL patients to identify key factors and predictive models associated with the risk of PTB. - Source: PubMed
Publication date: 2026/06/05
Hong SubeenUm Gi SooKang Byung SooKim OyoungLee Seon UiKo Hyun SunNam SanghoLee SeungokPark In YangShin Sun - Metabolic dysfunction-associated steatotic liver disease (MASLD) is a highly prevalent condition that progresses from hepatic steatosis to steatohepatitis, fibrosis, and cirrhosis. While metabolic and inflammatory drivers of disease progression are well recognized, emerging evidence suggests that endocrine modulators, including the insulin-like growth factor binding proteins (IGFBPs), play important roles in MASLD. Beyond their canonical role as insulin-like growth factor (IGF) carriers, IGFBPs act as dynamic regulators of hepatic metabolism, inflammation, and fibrotic remodeling through both IGF-dependent and IGF-independent mechanisms. Growing evidence indicates that IGFBP1 and IGFBP2 confer metabolic protection by promoting lipid oxidation and increasing insulin sensitivity. IGFBP3 and IGFBP5 exhibit dual actions: they restrain lipogenesis at early stages but promote hepatocellular injury and stellate cell activation during fibrosis. IGFBP7 is a predominantly pathogenic modulator that impairs insulin signaling, drives ferroptosis, and fosters fibrosis. By contrast, IGFBP4 and IGFBP6 remain less well characterized. This review integrates recent mechanistic and translational findings on IGFBPs in MASLD with evidence accumulated from recent studies, highlighting their potential as biomarkers for disease staging and as therapeutic targets for interventions. - Source: PubMed
Publication date: 2026/06/05
Fang KuoMiao JiSong Guobin - Polycystic ovary syndrome (PCOS) is a multisystem endocrine and metabolic disease characterized by chronic low-grade inflammation, ovulatory dysfunction, hyperandrogenism, and insulin resistance. Chronic inflammation modifies the IGF system that regulates ovarian function and glucose metabolism. HMGB1 is an alarmin related with both inflammation and insulin sensitivity, and we previously described the increased follicular fluid concentration of HMGB1 in PCOS. This study aimed to investigate changes in IGF system protein concentrations in follicular fluid from PCOS with respect to control subjects. - Source: PubMed
Publication date: 2026/06/05
Buia VeronicaCatellani CeciliaCroci StefaniaRighi BeatriceMorini DariaFalbo Angela ImmacolataNicoli AlessiaDe Fanti AlessandroBelloni LuciaAguzzoli LorenzoVillani Maria TeresaSartori ChiaraStreet Maria Elisabeth - Hypoxia is a hallmark of solid tumors, and hypoxia-inducible factors (HIFs) are the master transcription factors that allow cancer cells to sense and cope with a hypoxic microenvironment. However, the mechanism by which the HIF-mediated transcription process is precisely regulated remains poorly understood. Here, we demonstrate that the RNA helicase DDX21 facilitates breast tumor growth and metastasis by triggering HIF-mediated transcription elongation. Mechanistically, DDX21 induces the release of CDK9 from the 7SK complex, enhancing the interaction between CDK9 and HIF-1α. This interaction stimulates the transcription elongation of HIF target genes by elevating the enrichment of phosphorylated RNA Polymerase II at serine 2 on the hypoxia-response element of HIF target genes. These target genes, including IGFBP1, WNT1, WNT10B, TGFB1, PCK1, and SLC2A3, are critical for cancer cell proliferation and metastasis. Consequently, DDX21 enhances breast cancer cell proliferation, survival, migration, and invasion in vitro, and promotes breast tumor growth and metastasis in vivo. Importantly, DDX21 is highly expressed in breast tumors and correlates negatively with clinical outcomes in breast cancer patients. Our study reveals a novel mechanism of HIF regulation and positions DDX21 as a potential therapeutic target for disrupting the hypoxic adaptation machinery in breast cancer. - Source: PubMed
Publication date: 2026/06/15
Li GuangqiangDeng MingxiaZhu LeqingLei ZhiweiGuo RongLiu XiongChen RenwangXia XichunWen QiongDuan YuanyuanChen YanYin Zhinan - Perfluorooctanoic acid (PFOA), a widespread persistent environmental contaminant, has been associated with osteoarthritis (OA) onset and progression, though mechanisms remain unclear. This study elucidates PFOA's influence on OA pathogenesis, evaluates its effects on disease progression, and identifies diagnostic biomarkers. - Source: PubMed
Publication date: 2026/05/28
Huang XinzhouWei YongkunRao YaniWei YueChen HuiBao Yunping