Mouse anti-Human CD86, FITC Conjugated mAb
- Known as:
- Mouse (anti-) to-Human CD86, fluorecein Conjugated mAb
- Catalog number:
- 28206
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- Mouse anti-Human CD86 FITC Conjugated mAb
Related genes to: Mouse anti-Human CD86, FITC Conjugated mAb
- Gene:
- CD86 NIH gene
- Name:
- CD86 molecule
- Previous symbol:
- CD28LG2
- Synonyms:
- B7.2, B7-2
- Chromosome:
- 3q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1994-12-07
- Date modifiied:
- 2016-10-05
Related products to: Mouse anti-Human CD86, FITC Conjugated mAb
Related articles to: Mouse anti-Human CD86, FITC Conjugated mAb
- Adjuvants are critical for enhancing vaccine efficacy, however, conventional adjuvants often suffer from poor biocompatibility and limited immune activation profiles. Herein, we developed a nanoadjuvant by modifying a lentinan (LNT) backbone with polyethyleneimine (PEI) to generate a cationic LNT-PEI vector, which was then used to load SOCS1 siRNA, forming LNT-PEI/siRNA nanocomplexes. experiments demonstrated that LNT-PEI/siRNA effectively silenced gene expression, significantly upregulated the expression of CD80 and CD86, and promoted the secretion of TNF-α and IL-6. Furthermore, a vaccine was formulated by self-assembling the LNT-PEI/siRNA nanoadjuvant with the model antigen ovalbumin (OVA) to evaluate its immunostimulatory capacity. Biodistribution studies revealed that the vaccine formulation effectively targeted and accumulated in lymph nodes while reducing non-specific hepatic retention. Immunological evaluation showed that incorporation of LNT-PEI/siRNA markedly increased the proportions of CD11bF4/80 macrophages and CD11c dendritic cells, as well as CD3CD8a T cells in the spleen. It also upregulated costimulatory molecule expression and elevated serum levels of TNF-α, IL-6, and IFN-γ. In summary, the LNT-PEI/siRNA nanoadjuvant developed in this study successfully enhances immune responses, providing both a theoretical foundation and experimental basis for the development of next-generation vaccine adjuvants. - Source: PubMed
Publication date: 2026/08/14
Zhu YingShen YaoyanBao YumengMei CongjinZhou JuanChen Jinghua - Microporous annealed particle (MAP) scaffolds are injectable hydrogel biomaterials that promote tissue regeneration by enabling rapid cell infiltration and presenting reparative cues. Previous work showed that substituting L- with D-chiral residues in matrix metalloproteinase (MMP)-degradable crosslinkers induces adaptive immune-mediated skin regeneration and balanced macrophage responses in vivo, but the underlying mechanisms remain unclear. Here, we identify myeloid differentiation factor 2 (MD-2)-associated TLR4 signaling as a key mechanistic contributor to macrophage polarization driven by crosslinker chirality in MAP scaffolds. Macrophages cultured in D-chiral MAP (DMAP) scaffolds exhibited reduced iNOS, CD86, and TNF-α expression and shifted from an M1-like state toward M0-like phenotypes compared to L-chiral MAP (LMAP) and 2D controls. Competitive inhibition with soluble D-chiral MMP crosslinker peptide (DMMP) partially restored M1 activation, implicating direct peptide-macrophage interactions. Docking and surface plasmon resonance (SPR) analyses revealed higher-affinity binding of DMMP to MD-2 relative to L-chiral peptides. Accordingly, DMAP altered TLR4/MD-2 trafficking and attenuated endocytosis-dependent signaling. Engineering a second D-peptide crosslinker with enhanced MD-2 affinity (DMMP2) reduced inflammatory markers and promoted regenerative macrophage polarization. Together, these results establish peptide chirality as a tunable design parameter for modulating TLR4/MD-2 signaling and engineering immunomodulatory MAP scaffolds. - Source: PubMed
Publication date: 2026/08/13
Suarez-Arnedo AlejandraThomas Jeremy LLiu YiningCordero-Alvarado PabloKim AmyEspinoza April ChavezHarvey LeicaPoysungnoen KoravitLin FayanneYe ZhiyouSegura Tatiana - Oral squamous cell carcinoma (OSCC) is the most common malignant tumor in the head and neck region. Apolipoprotein C1 (APOC1) has been identified as an oncogene in multiple tumors, while its role and molecular mechanism in OSCC remain incompletely understood. - Source: PubMed
Publication date: 2026/08/11
Sun QiuwangyueZhang XiZhang Wei - Endometriosis (EMS) is a chronic inflammatory disorder involving ectopic endometrial tissue growth. This study investigated IL-33, CD1c+ dendritic cells (DCs) and their co-stimulatory molecules (CD40, CD80, CD86), and IL-17 A in the peritoneal fluid (PF) of EMS patients, and explored their interrelationships. - Source: PubMed
Publication date: 2026/08/13
Yuan WenHuang JiaoHe TaoLi HuanniWu Xianqing - To assess whether pretreatment intratumoral macrophage-associated and T-cell marker-positive areas are associated with treatment outcomes in patients with stage IV solid tumors receiving programmed cell death protein 1 (PD-1)-based immune checkpoint blockade, and whether tissue marker-positive areas correspond to peripheral blood monocyte subsets. - Source: PubMed
Publication date: 2026/08/12
Ohkuma RyotaroOnishi NobuyukiMisawa AyaWatanabe MakotoJin JianAriizumi HirotsuguShimokawa MasahiroIkeda GoSuzuki RisakoTsurui ToshiakiKubota YutaroSasaki YosukeHomma MayumiYoshimura KiyoshiYamochi ToshikoKobayashi ShinichiTsunoda TakuyaHoriike AtsushiWada Satoshi