Mouse anti-Human CD62P, FITC Conjugated mAb
- Known as:
- Mouse (anti-) to-Human CD62P, fluorecein Conjugated mAb
- Catalog number:
- 28191
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- Mouse anti-Human CD62P FITC Conjugated mAb
Related genes to: Mouse anti-Human CD62P, FITC Conjugated mAb
- Gene:
- SELP NIH gene
- Name:
- selectin P
- Previous symbol:
- GRMP
- Synonyms:
- CD62, PSEL, PADGEM, GMP140, CD62P
- Chromosome:
- 1q24.2
- Locus Type:
- gene with protein product
- Date approved:
- 1989-06-30
- Date modifiied:
- 2015-11-16
Related products to: Mouse anti-Human CD62P, FITC Conjugated mAb
Related articles to: Mouse anti-Human CD62P, FITC Conjugated mAb
- Selenium (Se) is a vital trace element necessary for fish growth and health. This research aimed to elucidate the beneficial impacts of coated sodium selenite (CSS) on sub-adult grass carp muscle and compared effects of CSS and sodium selenite (SS). A total of 450 healthy fish with an initial average body weight of 687.33 ± 1.15 g were randomly assigned to six groups. Fish in these groups were fed experimental diets supplemented with graded levels of CSS (0.028, 0.25, 0.50, 0.75, and 1.00 mg/kg Se) and one diet containing SS at 0.50 mg/kg Se, respectively, for an 8-week feeding trial. Results indicated that optimal CSS increased body length and Se concentrations in muscle and hepatopancreas ( < 0.05). The accumulated Se further up-regulated the expressions of selenoproteins (such as and ), which collectively improved antioxidant capacity (such as glutathione peroxidase [GPX] activity and L-glutathione [GSH] content]) and mitochondrial quality (such as fusion, biogenesis, and respiratory chain) ( < 0.05). These alterations improved muscle fiber development by upregulating the expression of genes related to protein synthesis (, , and ) and extracellular matrix synthesis (, , , , and ) ( < 0.05). Interestingly, at the 0.50 mg/kg Se supplementation, CSS and SS showed similar growth and muscle development, but different responses in signaling pathways, implying that CSS may confer additional physiological benefits. Overall, dietary Se could enhance muscle growth in sub-adult grass carp by dual mechanisms: enhancing antioxidant defenses and improving mitochondrial quality. - Source: PubMed
Publication date: 2026/04/03
Zhao FeiWu PeiJiang WeidanZhang HongyunLiu YangMa YaobinRen HongmeiJin XiaowanKuang YingguFeng LinZhou Xiaoqiu - P-selectin exists in two biologically distinct forms, soluble in plasma (sP-selectin) and membrane-bound on activated platelets (CD62P). Both have been linked to the pathophysiology of preeclampsia, but their comparative diagnostic and predictive performance have not been systematically analyzed. We conducted an original dual meta-analysis comparing soluble and platelet-bound P-selectin for the diagnosis and early prediction of pre-eclampsia. - Source: PubMed
Sucker ChristophEntezami MichaelSchroer Andreas - Megakaryopoiesis is an elaborate biological process that primarily occurs in the bone marrow. To gain deeper insights into molecular mechanisms driving normal megakaryopoiesis, we utilized an in vitro human megakaryocytic culture system based on mobilized peripheral blood-derived CD34 cells. Following fluorescence-activated cell sorting (FACS) isolation of CD41 and CD41 megakaryocyte (MK) subsets, mature MKs were confirmed through characterization of MK-specific surface markers, ploidy analysis, Giemsa staining, and immunofluorescence. Subsequent bulk RNA sequencing of these distinct populations enabled the identification of differentially expressed genes (DEGs) and enriched pathways. Based on our CD34-derived MK differentiation model, the expression of CD41 was found robustly induced by day 4 and further elevated by day 10. The CD41 population exhibited marked co-expression of CD42b and CD61, a significantly higher proportion of polyploid cells (≥16 N), along with characteristic morphological features of mature MKs, including proplatelet formation, cytoplasmic maturation, and cell size enlargement compared to the CD41 subset. Transcriptomic profiling of these two populations identified 1877 up-regulated and 1817 down-regulated DEGs in CD41 MKs. Protein-protein interaction (PPI) network analysis of the key DEGs revealed hub genes including VWF, PF4V1, SELP, PF4, GP1BA, CD40LG, PPBP, CLEC1B, P2RY12, and THBS1. Functional enrichment underscored the acquisition of migratory, adhesive, and secretory capacities, marked by significant upregulation of platelet activation and wound healing signatures. Pathway analysis further indicated coordinated activation of focal adhesion, cytoskeletal reorganization, glycerolipid metabolism, and neuroactive ligand-receptor interaction during maturation. This study provides an integrative transcriptomic blueprint of human MK maturation and highlights the novel candidate targets for thrombopoiesis. - Source: PubMed
Publication date: 2026/05/15
Zhang ZiyanWang YueLiu Peng - To explore the molecular mechanisms underlying cystoid macular edema (CME) through protein-protein interaction (PPI) network analysis, identifying key regulatory proteins, functional modules, and enriched biological pathways relevant to its pathogenesis. - Source: PubMed
Shariati Mehrdad Motamed - A high rate of metastasis remains a challenge for the treatment of adenoid cystic carcinoma (ACC), yet the underlying mechanism of lung metastasis remains elusive. By integrating single-cell RNA sequencing and bulk transcriptomics with multiplex immunohistochemistry, we identified a metastatic niche consisting of IL1B tumor-associated macrophages (TAMs), CD24 luminal-like tumor cells, ACKR1 endothelial cells (ECs) and HSPA1ACD8 T cells. Importantly, we revealed that IL1B TAMs play diverse roles in the processes of tumor cell intravasation and colonization, two fundamental steps supporting metastatic outgrowth. In primary lesions, IL1B TAMs release elevated levels of VEGFA and MMPs, thereby coupling sprouting angiogenesis with extracellular matrix remodeling to facilitate cancer cell intravasation. In metastatic lesions, IL1B TAMs bind to IL-1R1 on ACKR1 ECs to upregulate the expression of the adhesion molecule SELP, which can attract CD24 luminal-like tumor cells for lung colonization. IL1B TAMs also increase the stress response state of HSPA1ACD8 T-cell recruitment and induce T-cell exhaustion, thereby facilitating the survival of disseminated tumor cells. Mechanistically, MIF derived from CD24 tumor cells increases the transcription of IL1B in TAMs. We also reported that the infiltration of IL1B TAMs increased steadily with increasing lung metastatic progression in mice bearing metastatic ACC cells. Elevated plasma IL-1β and VEGFA levels are associated with increased metastatic burden and poor overall survival in patients with ACC. Our findings reveal the critical role of IL1B TAMs in reshaping the metastatic tumor immune microenvironment and reveal a potential therapeutic vulnerability for metastatic ACC. - Source: PubMed
Publication date: 2026/05/16
Wang YuZheng JianweiZhang KungeMo WeipengYang XiaotianCui PengyuLiu ChaoZheng LeiXia ShunjinSun MengyuWang BoMei MeiZhou XuanRen Yu