ARNTL2 Antibody
- Known as:
- ARNTL2 Antibody
- Catalog number:
- 39937
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- ARNTL2 Antibody
Related genes to: ARNTL2 Antibody
- Gene:
- ARNTL2 NIH gene
- Name:
- aryl hydrocarbon receptor nuclear translocator like 2
- Previous symbol:
- -
- Synonyms:
- BMAL2, MOP9, CLIF, PASD9, bHLHe6
- Chromosome:
- 12p11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2003-08-21
- Date modifiied:
- 2016-10-05
Related products to: ARNTL2 Antibody
Related articles to: ARNTL2 Antibody
- Immunotherapy resistance in lung adenocarcinoma (LUAD) remains a critical clinical challenge, and the mechanisms underlying resistance-associated intratumoral heterogeneity are poorly characterized. - Source: PubMed
Publication date: 2026/08/15
Qiu ZhengangZhao HuiLyu QiongLi ZhigangXi QiujiangYe BingqingLong QianshanLai ZhengxinCao XiangZhong WenjuanZhang YuLiu Rongrong - Circadian rhythms synchronize physiological processes with the light-dark cycle and regulate biological functions relevant to cancer, including cell-cycle control, metabolism, DNA repair, immunity, and tissue homeostasis. Growing evidence indicates that disruption of these temporal mechanisms contributes to tumor initiation, progression, metastasis, and treatment response. In colorectal cancer (CRC), circadian clock dysregulation has emerged as an important component of tumor biology. A systematic search identified 1338 records, of which 43 studies met the eligibility criteria (20 human, 19 experimental, and 4 chronotherapy studies). Across the included studies, statistically significant associations were consistently reported between dysregulation of clock genes such as , , , , , , and and alterations in proliferation, metabolism, epithelial plasticity, immune regulation, metastatic potential, and treatment responsiveness. Experimental evidence also supported interactions with Wnt signaling, ferroptosis, oxidative-stress adaptation, epithelial-mesenchymal remodeling, and a proposed clock-microbiota-immune axis. Overall, the available evidence indicates that circadian dysregulation represents a systems-level disturbance that gives rise to a multidimensional biological condition, here referred to as the Tumor Temporal State, integrating the metabolic, immune, invasive, and therapeutic dimensions of colorectal cancer biology. - Source: PubMed
Publication date: 2026/07/10
Tarasewicz MirosławZbroch EdytaMarkowski Adam R - The coexistence of skin diseases is common. Although molecular studies have made significant efforts to understand each disease entity, the shared molecular basis explaining their concurrence remains largely unknown. This study aims to identify common upregulated genes in skin diseases that may serve as potential biomarkers. - Source: PubMed
Alsabbagh Manahel Mahmood - Obsessive-compulsive disorder (OCD) and allergic diseases co-occur far more often than expected, yet genome-wide genetic correlations are typically modest or negative. The objective of this study was to test whether OCD and allergic diseases show convergence at the level of pre-specified biological pathways, especially synaptic pruning and circadian regulation, rather than at the level of broad genome-wide correlation. - Source: PubMed
Publication date: 2026/05/27
Cheung Ngo - This study investigated the prognostic value and molecular mechanisms of miR-517c-3p in lung cancer. miR-517c-3p in 112 lung cancer tissues was detected using qRT-PCR. Kaplan-Meier survival analysis and Cox regression were used to assess its prognostic significance. Functional experiments, including cell proliferation, migration, and invasion, were conducted in lung cancer cell lines (H1229, A549) after miR-517c-3p overexpression. Target gene prediction and validation were performed using bioinformatics tools and dual-luciferase reporter assays. The regulatory effects of miR-517c-3p on ARNTL2 were further explored through gene overexpression and rescue experiments. miR-517c-3p was significantly downregulated in lung cancer tissues (p < 0.001) and correlated with advanced TNM stage, lymph node metastasis, and larger tumor size. Patients with low miR-517c-3p expression exhibited poorer overall survival (p < 0.001), and Cox regression identified miR-517c-3p as an independent prognostic factor (HR = 0.110, 95% CI = 0.047-0.256). Functional assays demonstrated that miR-517c-3p overexpression inhibited lung cancer cell proliferation, migration, and invasion. Dual-luciferase reporter assays confirmed ARNTL2 as a direct target of miR-517c-3p, and ARNTL2 restoration reversed the suppressive effects of miR-517c-3p on tumor progression. miR-517c-3p is significantly downregulated in lung cancer and associated with poor patient prognosis. Furthermore, miR-517c-3p suppresses tumor progression by directly targeting ARNTL2. - Source: PubMed
Chen JiaRen QiuSun BowenSun YongJiang HongjieWang Junwen