NEFL antibody
- Known as:
- NEFL (anti-)
- Catalog number:
- 38115
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- NEFL antibody
Related genes to: NEFL antibody
- Gene:
- NEFL NIH gene
- Name:
- neurofilament light
- Previous symbol:
- -
- Synonyms:
- NFL, CMT1F, CMT2E, NF68, PPP1R110
- Chromosome:
- 8p21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-06-22
- Date modifiied:
- 2019-04-23
Related products to: NEFL antibody
Related articles to: NEFL antibody
- Immune signaling alterations have been implicated in Alzheimer's disease (AD) pathophysiology, but their heterogeneity across the disease continuum in real-world cohorts is poorly characterized, limiting the development of stratified immunomodulatory approaches. - Source: PubMed
Birditt Katherine RMavromati KalliopiSwann PeterQuinn TerenceHainsworth Atticus HHughes LynneO'Brien John TMcEwan WilliamMalpetti Maura - This study aimed to explore the mediating role of white blood cell (WBC) count in the relationship between the advanced lung cancer inflammation index (ALI) and serum neurofilament light chain (sNfL) levels. We conducted a cross-sectional analysis of 1725 adult participants from the 2013 to 2014 National Health and Nutrition Examination Survey. ALI was calculated as body mass index × serum albumin/neutrophil-to-lymphocyte ratio, and participants were categorized into quartiles based on ALI distribution. Associations among ALI, WBC count, and sNfL levels were examined using weighted multivariable linear regression, nonlinear curve fitting, and mediation analysis. Higher ALI values were significantly associated with lower sNfL concentrations (β = -0.04 per unit increase; 95% confidence interval [CI]: -0.06--0.02; P = .0007), demonstrating a clear dose-response pattern across ALI quartiles. A nonlinear relationship was identified, with a threshold effect at an ALI value of 71.64. Below this threshold, ALI showed a stronger inverse association with sNfL (β = -0.14; 95% CI: -0.21--0.08; P < .0001), which attenuated above the threshold (β = -0.01; P = .63). WBC count partially mediated the association between ALI and sNfL, accounting for 21.04% of the total effect (95% CI: 6.85-43.18%; P = .006). ALI is inversely associated with serum sNfL levels in the general United States adult population, with WBC count acting as a significant mediator. Clinically, these findings suggest that ALI, a readily available composite marker of systemic inflammation and nutritional status, may help identify individuals at higher risk of neuroaxonal injury, thereby supporting its potential utility in population-level neurodegenerative risk stratification and early preventive assessment. Further longitudinal studies are warranted to confirm these associations and clarify their prognostic implications. - Source: PubMed
Wang ShuangMa HuiShi QimeiZong ShoujianWang GuangjieHu XiaojieSu HaifangSun GuizhiYun Chunmei - Blood-based biomarkers are increasingly used to support the biological diagnosis of Alzheimer's disease (AD), but their prognostic value in subjective cognitive decline (SCD) remains incompletely understood. We investigated whether plasma p-tau217, p-tau181, and neurofilament light chain (NfL) are associated with domain-specific longitudinal cognitive changes in SCD. - Source: PubMed
Publication date: 2026/06/26
Giacomucci GiuliaPieri AliceBagnoli SilviaGiametta Katia MariaPadiglioni SoniaMoschini ValentinaMorinelli CarmenTabbì Silvia Maria RitaSensi ChiaraMistretta LorenzoCrucitti ChiaraNacmias BenedettaBessi Valentina - Whether surgical haematoma evacuation leads to reduced brain damage in patients with spontaneous supratentorial intracerebral haemorrhage (SSICH) remains unknown. Blood biomarkers reflecting brain damage could aid in prognosticating the clinical outcome and hence support quantifying the benefit of surgical interventions. - Source: PubMed
Publication date: 2026/06/25
Hallenberger Tim JonasWillemse ElineBrégère CatherineGhosh NilabhBonati Leo HMaleska Maceski AleksandraBenkert PascalFischer UrsSoleman JehudaLeppert DavidGuzman RaphaelKuhle Jens - Brain health disorders (BHDs) remain a concern for people with HIV (PWH) despite antiretroviral therapy access and viral suppression. The contribution of HIV to brain health is often obscured by comorbidities in high-income settings which are less prevalent in sub-Saharan Africa. Neurofilament light chain (NfL), a biomarker of axonal injury, may offer insight into underlying mechanisms. 338 virally-suppressed PWH and 250 people without HIV (PWoH) completed a Research Domain Criteria-informed battery assessing cognitive, sensorimotor, and social processing systems. Demographically-adjusted norms were derived from PWoH. Serostatus differences in impairment (≥ 1SD below the mean) were examined using multivariable logistic regression. Additional models examined associations between NfL (plasma, cerebrospinal fluid [CSF]) and task performance. PWH were similar to PWoH in age (43.9 vs. 43.5yrs), sex (female, 54 vs. 46%), and education (6.1 vs. 5.8yrs). PWH had higher odds of impairment in the cognitive control and attention (Color Trails, Symbol Digit) and sensorimotor (Grooved Pegboard) domains. Plasma NfL was associated with sensorimotor impairment in both groups. Similar trends held in CSF NfL but did not reach statistical significance, likely due to sample size (n = 85). Cognitive and sensorimotor difficulties are common in PWH in Rakai, independent of typical Western confounders. The profile of impairment differs from reports in high-income settings where declarative memory deficits are often observed. NfL was associated with sensorimotor impairment, suggesting that NfL may capture ongoing axonal injury and motor system vulnerability in PWH and PWoH. These findings suggest NfL's potential as a biomarker of sensorimotor impairment in sub-Saharan Africa. - Source: PubMed
Publication date: 2026/06/22
Ridgeway KDastgheyb Raha MEaster Rebecca EShorer Eran FAnok AggreyTomusange StephenMannarino JulieSaylor DeannaGisslen MagnusZetterberg HenrikNakasujja NoelineNakigozi GertrudePaul RobertRubin Leah H