MLC2 (Phospho-Tyr118) Antibody
- Known as:
- MLC2 (Phospho-Tyr118) Antibody
- Catalog number:
- 11589
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Signalway
- Gene target:
- MLC2 (Phospho-Tyr118) Antibody
Related genes to: MLC2 (Phospho-Tyr118) Antibody
- Gene:
- MYL9 NIH gene
- Name:
- myosin light chain 9
- Previous symbol:
- -
- Synonyms:
- MYRL2, MLC2, LC20, MRLC1
- Chromosome:
- 20q11.23
- Locus Type:
- gene with protein product
- Date approved:
- 2001-09-17
- Date modifiied:
- 2015-11-13
- Gene:
- MYLPF NIH gene
- Name:
- myosin light chain, phosphorylatable, fast skeletal muscle
- Previous symbol:
- -
- Synonyms:
- MRLC2, HUMMLC2B, MYL11
- Chromosome:
- 16p11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2009-03-06
- Date modifiied:
- 2016-07-18
Related products to: MLC2 (Phospho-Tyr118) Antibody
Related articles to: MLC2 (Phospho-Tyr118) Antibody
- Turner syndrome (TS) is a sex chromosome aneuploidy with a variable spectrum of symptoms including short stature, ovarian failure and skeletal abnormalities. The etiology of TS is complex, and the mechanisms driving its pathogenesis remain unclear. In our study, we used the online Gene Expression Omnibus (GEO) microarray expression profiling dataset GSE46687 to identify differentially expressed genes (DEGs) between monosomy X TS patients and normal female individuals. The relevant data on 26 subjects with TS (45,XO) and 10 subjects with the normal karyotype (46,XX) was investigated. Then, tissue-specific gene expression, functional enrichment, and protein-protein interaction (PPI) network analyses were performed, and the key modules were identified. In total, 25 upregulated and 60 downregulated genes were identified in the differential expression analysis. The tissue-specific gene expression analysis of the DEGs revealed that the system with the most highly enriched tissue-specific gene expression was the hematologic/immune system, followed by the skin/skeletal muscle and neurologic systems. The PPI network analysis, construction of key modules and manual screening of tissue-specific gene expression resulted in the identification of the following five genes of interest: , and . and are involved in the hematologic/immune system, and are related to the circulatory system, and is related to skeletal abnormalities. In addition, several genes of interest with possible roles in the pathogenesis of TS were identified as being associated with the hematologic/immune system or metabolism. This discovery-driven analysis may be a useful method for elucidating novel mechanisms underlying TS. However, more experiments are needed to further explore the relationships between these genes and TS in the future. - Source: PubMed
Publication date: 2020/03/06
Wang HaoZhu HuiZhu WenjiaoXu YueWang NanHan BingSong HuaidongQiao Jie - To learn more about cancer-associated fibroblasts (CAFs), we have isolated fibroblasts from different stages of breast cancer progression and analysed their function and gene expression. These analyses reveal that activation of the YAP transcription factor is a signature feature of CAFs. YAP function is required for CAFs to promote matrix stiffening, cancer cell invasion and angiogenesis. Remodelling of the ECM and promotion of cancer cell invasion requires the actomyosin cytoskeleton. YAP regulates the expression of several cytoskeletal regulators, including ANLN and DIAPH3, and controls the protein levels of MYL9 (also known as MLC2). Matrix stiffening further enhances YAP activation, thus establishing a feed-forward self-reinforcing loop that helps to maintain the CAF phenotype. Actomyosin contractility and Src function are required for YAP activation by stiff matrices. Further, transient ROCK inhibition is able to disrupt the feed-forward loop, leading to a long-lasting reversion of the CAF phenotype. - Source: PubMed
Publication date: 2013/05/26
Calvo FernandoEge NilGrande-Garcia AraceliHooper StevenJenkins Robert PChaudhry Shahid IHarrington KevinWilliamson PeterMoeendarbary EmadCharras GuillaumeSahai Erik