PTX3 Polyclonal Antibody, Biotin Conjugated
- Known as:
- PTX3 Polyclonal Antibody, Biotin Conjugated
- Catalog number:
- a-0488-050
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Epigentek inc
- Gene target:
- PTX3 Polyclonal Antibody Biotin Conjugated
Related genes to: PTX3 Polyclonal Antibody, Biotin Conjugated
- Gene:
- PTX3 NIH gene
- Name:
- pentraxin 3
- Previous symbol:
- TNFAIP5
- Synonyms:
- TSG-14
- Chromosome:
- 3q25.32
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-08
- Date modifiied:
- 2016-10-05
Related products to: PTX3 Polyclonal Antibody, Biotin Conjugated
Related articles to: PTX3 Polyclonal Antibody, Biotin Conjugated
- Oral squamous cell carcinoma (OSCC) poses major clinical challenges because of its invasiveness and poor prognosis. Pentraxin 3 (PTX3) is an immune-modulating protein implicated in various types of cancer, although its role in OSCC remains unclear. In this study, we examined the functional roles and underlying molecular mechanisms of PTX3 in OSCC. - Source: PubMed
Publication date: 2026/07/01
Yeh Chia-MingSu Chun-WenYang Wei-EnLin Chiao-WenTang Chih-HsinYang Shun-FaChen Mu-Kuan - Refinement of in vitro maturation (IVM) protocols is critical for enhancing sheep oocyte production efficiency and supporting genetic improvement in breeding programs. However, the developmental competence of in vitro-matured oocytes remains suboptimal partly because conventional culture systems fail to fully recapitulate the complex paracrine interactions within the ovarian follicular microenvironment. Kit Ligand (KL), a granulosa cell-derived growth factor, plays a pivotal role in mediating oocyte-cumulus cell communication during in vivo maturation, but its functional role and optimal supplementation conditions in sheep IVM systems remain unclear. In this study, we investigated the effects of recombinant KL supplementation during IVM on nuclear maturation, cytoplasmic maturation, intracellular homeostasis, and subsequent embryonic development in sheep oocytes. Supplementation with 30 ng/mL KL significantly increased the first polar body extrusion rate and enhanced cumulus expansion. KL treatment upregulated the expression of cumulus expansion-related genes (PTX3, HAS2, PTGS2, and TNFαIP6) and promoted cortical granule redistribution to the oocyte cortex. In addition, KL reduced intracellular reactive oxygen species levels, decreased the BAX/BCL-2 ratio, increased mitochondrial membrane potential, and improved mitochondrial distribution. Following in vitro fertilization, KL-treated oocytes exhibited higher cleavage and blastocyst formation rates compared with the control group. These findings suggest that KL supplementation improves oocyte developmental competence in sheep, potentially through regulation of cumulus cell activity and maintenance of intracellular homeostasis. - Source: PubMed
Publication date: 2026/06/28
Yang QiSun DuiJiang Zhao-YuTang Rui-HaoZhang Rui-FengZhang Xiao-YiLi Wen-YingLi Yi-TongLiu AoZhang Chun-LanJia Zhi-WenFeng Meng-LeiXue Fang-RuiSong Chun-RuZhang Xiao-JieLiang Cheng-Guang - Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive cancer and was ranked among the top seven leading causes of cancer-related deaths in South Africa in 2020. Highlighting the urgent need for ongoing research to identify reliable biomarkers to improve clinical outcomes. This study compared the plasma proteomes of patients with PDAC, those with benign biliary pathologies (BBP), and healthy controls (HC). We used Mag-Net, a magnetic-bead-based method that enriches membrane-bound vesicles. Comparative analyses identified distinct and overlapping dysregulated proteins between PDAC, BBP, and HC. PDAC showed enrichment for epithelial-mesenchymal transition, complement activation, hypoxia, glycolysis, and extracellular matrix remodeling pathways, consistent with aggressive tumor biology. Proteins including SPP1, THBS2, PTX3, FBLN2, SDC1, CTSS, and VCAN were significantly increased in PDAC, with LRG1 showing the strongest association with disease severity. Proteins, namely GPNMB, H4C1, SAA1, and CCDC47, demonstrated progressive upregulation across disease comparisons, suggesting potential relevance to disease progression. These findings demonstrate that plasma proteomics provides discriminatory molecular insights and supports the development of population-relevant biomarker panels. While several candidate proteins show promise for inclusion in multianalyte panels, further validation in larger cohorts is necessary to establish their diagnostic and translational utility for early detection, risk stratification, and improved differential diagnosis of PDAC. - Source: PubMed
Publication date: 2026/06/30
Buthelezi SindisiweElebo NnennaNaicker PrevinMokoena RethabileDubazana SineguguGovender IreshynMamputha SiphoEllero AndreaStoychev StoyanMazibuko JeanetOjo DupeCandy GeoffreyDevar JohnCacciatore StefanoOmoshoro-Jones JonesNweke Ekene Emmanuel - To investigate the diagnostic efficacy of antinuclear antibody spectrum(ANAs) combined with serum pentraxin 3(PTX3) and chemokine ligand 19(CCL19) for systemic lupus erythematosus (SLE). - Source: PubMed
Liu QingZhang JianqiaoLiu MeichenChen DongZhang Meng - Low-pathogenic avian influenza viruses (LPAIVs) show pathogenesis variations, suggested of being impacted by virus and host characteristics. This study aimed to understand the interaction of virus and host factors in LPAIV reproductive tract infection. Oviduct organ cultures (OOCs) were prepared from two chicken lines, brown layers (BL) and white layers (WL), to compare virus replication, microscopical lesions, and host-immune responses between two atypical virulent LPAIV strains H3N1 (A/chicken/Belgium/460/2019) and H6N1 (A/chicken/Netherlands/917/2010), and an avirulent H9N2 strain (A/chicken/Saudi Arabia/2525/2000). mRNA levels of interferon λ (IFN λ), inducible nitric oxide synthase (iNOS), host factors such as importin (Imp) α3, α8, and chemerin were measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR). High-throughput transcriptomic profiling of innate immune genes using a quantitative polymerase chain reaction (qPCR) array focused on H3N1- and H9N2-infected BL-OOCs. H3N1- and H6N1-infected BL-OOCs showed significantly higher viral loads compared with H9N2-inoculated OOCs (p < 0.05). This was associated with higher mRNA levels of innate-immunity related genes, including Pentraxin (PTX3) at 48 hours post-infection (hpi) after H9N2 inoculation. Compared with H9N2, H3N1 triggered a stronger yet delayed innate immune response at 48 hpi with an 8- and 256-fold increase in IFN λ and C-C motif chemokine ligand 4 (CCL4) expression, respectively, along with upregulation of Imp α3 in BL-OOCs. WL-OOCs were less susceptible to H6N1 with lower viral loads compared with BL-OOCs, which coincided with lower IFN λ expression levels after virus infection (p < 0.05). Overall, the OOCs model was a suitable model to demonstrate variable pathogenicity of LPAIV strains across chicken genotypes. Variations in host responses were detected impacting virus replication in a strain-dependent manner. - Source: PubMed
Publication date: 2026/06/25
Abukhadra Basel ABexter FrederikMohamed Sana IVervelde LonnekeSutton Katede Wit SjaakRautenschlein Silke