PTX3 Monoclonal Antibody [MNB4]
- Known as:
- PTX3 Monoclonal Antibody [MNB4]
- Catalog number:
- a-0568-100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Epigentek inc
- Gene target:
- PTX3 Monoclonal Antibody [MNB4]
Related genes to: PTX3 Monoclonal Antibody [MNB4]
- Gene:
- PTX3 NIH gene
- Name:
- pentraxin 3
- Previous symbol:
- TNFAIP5
- Synonyms:
- TSG-14
- Chromosome:
- 3q25.32
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-08
- Date modifiied:
- 2016-10-05
Related products to: PTX3 Monoclonal Antibody [MNB4]
Related articles to: PTX3 Monoclonal Antibody [MNB4]
- Dengue virus (DENV) infection can manifest as dengue fever (DF) or dengue hemorrhagic fever (DHF), although DHF often becomes clinically apparent around defervescence. How complement components and other immune responses evolve over the course of illness from the febrile to recovery phase remains incompletely defined. This study characterized circulating complement activation and immune mediators in DF and DHF using paired febrile and early-recovery samples. - Source: PubMed
Publication date: 2026/06/04
Saptarini IkaMasyeni SriHarahap Alida RoswitaGiantini AstutiNugroho PringgodigdoHandito AgusHendarwan HarimatSusilo AdityoHaryanto SotianingsihFitriani DesiSasmono R TedjoNelwan Erni Juwita - Silica nanoparticles (SiNPs) are considered as one of the excellent alternative negative electrode materials for optimizing the storage performance of lithium-ion batteries. Therefore, with the global transition to new energy, their production may rapidly increase, but there is still a lack of relevant research on occupational exposure risks, especially respiratory toxicity mechanisms and biomarkers, associated with lithium-ion battery-related SiNPs. This study investigated the mechanism of toxic effects and possible biomarkers of SiNPs on human bronchial epithelial cells (BEAS-2B) using integrative transcriptomic, proteomic, and metabolomic approaches. SiNPs used in this study were selected as the most relevant type of negative electrode material for lithium-ion batteries, and their physical and chemical properties were characterized in detail. It was found that SiNPs induced significant concentration- and time-dependent cytotoxicity on BEAS-2B cells. SiNPs could alter the multiomics phenotype of cells after treatment with 50 μg/mL for 24 h. Multiomic joint analysis found that SiNPs may have induced cytotoxicity through toxic pathways, including oxidative stress, inflammation, and fibrosis, screening possible biomarkers such as PTX3, SESN2, STC2, IL-6, CLDN1, and COL14A1. This study revealed the possible mechanisms and biomarkers of respiratory toxicity of lithium-ion battery-related SiNPs and also suggested that integrative omic analyses could be a useful approach for evaluating the toxicity of novel nanoparticles. - Source: PubMed
Publication date: 2026/06/03
Zhou XinyanShi JiaqiMa YingZhang YiLi XiaojinPeng BinshuaiJia GuangChen Zhangjian - Diabetic kidney disease (DKD) is characterized by tubular EMT and fibrosis. So far, the pathogenesis of DKD is still not fully understood. Pentraxin 3 (PTX3), an inflammatory regulator, is overexpressed in DKD due to hyperglycemia. PTX3 amplifies inflammation by promoting inflammatory cytokine release (TNF-α, IL-6) and activating the nuclear factor kappa-B (NF-κB) pathway. Subsequently, it triggers the c-Jun N-terminal kinase (JNK) signaling pathway, enhancing AP-1-mediated transcription of inflammatory genes (MCP-1, ICAM-1). JNK also upregulates EMT markers (α-SMA, N-cadherin) through increased transforming growth factor TGF-β1, accelerating renal fibrosis. Targeting the PTX3-JNK axis with neutralizing antibodies or inhibitors mitigates inflammation and EMT, suggesting PTX3 as a potential anti-fibrotic target in DKD. - Source: PubMed
Publication date: 2026/05/20
Ma XuezhenMa ChuntaoZhou XiaochunWang JianqinZhang WenkaiNiu QiaoqiaoLi XuanZhang Yaxin - Intestinal lymphatic vessels are essential for dietary lipid absorption and immune cell trafficking. Villus lymphatic capillaries, lacteals, undergo continuous VEGF-C-dependent renewal to function in a hyperosmolar, inflammatory environment exposed to dietary and microbial by-products. To define mechanisms underlying this adaptation, we integrated new and published single-cell RNA-sequencing datasets of murine small intestinal lymphatic endothelial cells (LECs). Lacteal LECs resembled Ptx3+ immune-interacting LECs and were characterized by high expression of water channel AQP1. LEC-specific Aqp1 deletion reduced lacteal length, impaired lipid uptake, and limited weight gain on a high-fat diet, while mosaic deletion revealed a cell-autonomous requirement for AQP1 in LEC positioning at hyperosmolar tip regions. AQP1 promoted LEC migration under hyperosmotic stress by preserving cytoskeletal and junctional remodeling and alleviating osmotic stress-induced transcriptional programs. AQP1 was upregulated during inflammatory remodeling in lymphedema and lymphatic malformations, but not during embryonic lymphangiogenesis. These findings link lacteal regeneration to inflammatory lymphatic remodeling and highlight tissue osmolarity as a biophysical determinant of postnatal lymphangiogenesis. - Source: PubMed
Publication date: 2026/06/01
Roci IrenaKim Jaeryungde Korodi KellyWyss TaniaBernier-Latmani JeremiahArroz-Madeira SilviaGonzález-Loyola AlejandraBovay EstherGrenningloh NadiaSchoofs HansJeon Noo LiGiampietro CostanzaMäkinen TaijaNoël AgnèsPetrova Tatiana V - Tumor necrosis factor-alpha-induced proteins (TNFAIPs) are key regulators of inflammation, apoptosis, and immune signaling, yet their integrated roles in breast cancer (BC) remain poorly characterized. While individual TNFAIP members have been studied in other cancers, a comprehensive multi-omics characterization of this gene family in BC is still needed. - Source: PubMed
Publication date: 2026/05/29
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