PTX3 Monoclonal Antibody [MNB4]
- Known as:
- PTX3 Monoclonal Antibody [MNB4]
- Catalog number:
- a-0568-100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Epigentek inc
- Gene target:
- PTX3 Monoclonal Antibody [MNB4]
Related genes to: PTX3 Monoclonal Antibody [MNB4]
- Gene:
- PTX3 NIH gene
- Name:
- pentraxin 3
- Previous symbol:
- TNFAIP5
- Synonyms:
- TSG-14
- Chromosome:
- 3q25.32
- Locus Type:
- gene with protein product
- Date approved:
- 1993-11-08
- Date modifiied:
- 2016-10-05
Related products to: PTX3 Monoclonal Antibody [MNB4]
Related articles to: PTX3 Monoclonal Antibody [MNB4]
- For chronic obstructive pulmonary disease (COPD), Bufei Yishen formula (BYF) is an established therapy for COPD, and its effective component compatibility of BYF III (ECC-BYF III) demonstrates comparable efficacy. However, the underlying mechanisms of ECC-BYF III in COPD treatment remain unclear. We aimed to identify the pivotal genes in COPD and explore the mechanism by which ECC-BYF III exerts its effects. - Source: PubMed
Publication date: 2026/08/06
Lu RuilongMiao YufangGuan QingzhouSong MengweiDong HaoranTian YangeRen ZhouxinZhang Lanxi - Pentraxin-3 (PTX-3) is a humoral pattern recognition receptor involved in innate immunity and inflammation regulation, but its relationship with lung function remains unclear. - Source: PubMed
Publication date: 2026/08/10
Tuncerler GultenAtar Bese SimgeErge DuyguCevik OzgeUysal Pinar - In this multicentric study, we found no association regarding incidence or outcome between common single nucleotide polymorphisms in PTX3 and CLEC7A and invasive pulmonary aspergillosis in patients with severe viral pneumonia. The distinct pathophysiology of virus-associated pulmonary aspergillosis warrants exploration of genetic variation in novel candidates. - Source: PubMed
Publication date: 2026/08/07
Feys SimonHeylen JannesGonçalves Samuel MPereira InêsJacobs CatoLauwers Hanne MoonBeeckmans HanneBourgeois MarcDebaveye YvesDepuydt PieterFrederiks PascalHermans GreetHoenigl MartinMaessen LennMeersseman PhilippeLagrou KatrienLormans PietPeetermans MarijkeStarick Marick RThevissen KarinVanderbeke LoreVos RobinWilmer Alexandervan de Veerdonk Frank LVan Weyenbergh Johan Cunha CristinaWauters JoostCarvalho Agostinho - Pentraxin 3 (PTX3) responds rapidly to inflammatory signals. This study investigated the functional involvement of PTX3 in angiotensin II (Ang II)-mediated cardiac hypertrophy pathogenesis, with particular focus on its potential regulation through inflammatory pathways and oxidative stress mechanisms. In vivo, chronic Ang II infusion over 4 weeks was used to induce hypertrophic cardiomyopathy in mice. In parallel, an in vitro model of cardiomyocyte hypertrophy was established by treating neonatal rat cardiomyocytes (NRCMs) with Ang II for 24 h. Ang II treatment significantly increased PTX3 expression, an effect observed in both mouse heart tissue and NRCMs. The cardiac hypertrophy and fibrosis in mice treated with Ang II were alleviated by PTX3 knockout. Genetic ablation of PTX3 attenuated Ang II-induced upregulation of cardiac hypertrophy markers in mice hearts, including atrial natriuretic peptide, brain natriuretic peptide, and beta-myosin heavy chain. Additionally, PTX3 knockout suppressed the elevation of pro-inflammatory cytokines, including tumour necrosis factor-alpha and interleukin-1beta, following Ang II stimulation. Genetic deficiency of PTX3 significantly ameliorated cardiac oxidative stress potentiated by Ang II infusion. These outcomes showed that targeting of PTX3 could ameliorate hypertrophic cardiomyopathy via attenuation of inflammatory response and oxidative stress. PTX3 may be a target for therapy of hypertrophic cardiomyopathy in the future. - Source: PubMed
Tan QimingGong XiaoxuanWu TianLi ChenLiu KunHou Daorong - Pentraxin 3 (PTX3) is an inflammatory mediator involved in tumorigenesis; however, its role in tumor immune evasion remains elusive. Herein, we demonstrate that PTX3 promotes immune evasion in breast cancer by upregulating PD-L1. - Source: PubMed
Publication date: 2026/08/03
Jing LiyuanLun JieXu JianxinJin ZhengyuLiu XingqianWang YuZhang YuyingGao MinYu MengchaoZhang HongweiFang Jing