RGMA Polyclonal Antibody [AT115]
- Known as:
- RGMA Polyclonal Antibody [AT115]
- Catalog number:
- a-0503-100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Epigentek inc
- Gene target:
- RGMA Polyclonal Antibody [AT115]
Related genes to: RGMA Polyclonal Antibody [AT115]
- Gene:
- RGMA NIH gene
- Name:
- repulsive guidance molecule BMP co-receptor a
- Previous symbol:
- -
- Synonyms:
- RGM, RGMa
- Chromosome:
- 15q26.1
- Locus Type:
- gene with protein product
- Date approved:
- 2004-02-04
- Date modifiied:
- 2018-01-11
Related products to: RGMA Polyclonal Antibody [AT115]
Related articles to: RGMA Polyclonal Antibody [AT115]
- To identify drug-associated risk signals for neovascular age-related macular degeneration (nAMD) and explore their biological basis. - Source: PubMed
Publication date: 2026/06/01
Sun HongBu FengjiaoXin XiuYan JingchaoHuang Taomin - Calycosin-7-O-β-D-glucoside (CG), a bioactive compound extracted from the traditional Chinese herb Astragalus (AR), exhibits diverse biological activities, including anti-oxidative and anti-inflammatory effects, and has shown protective properties in ischemia-reperfusion (I/R) injury. While previous studies have demonstrated that CG mitigates I/R injury primarily through its anti-oxidative and anti-inflammatory actions, its potential role in promoting neuroregeneration-a critical process for stroke recovery-remains unclear, and the underlying mechanisms have yet to be elucidated. In this study, an ischemic stroke model was established in rats via middle cerebral artery occlusion (MCAO). Seven days after CG treatment, cerebral infarct volume was assessed using triphenyltetrazolium chloride (TTC) staining, while neurological function was evaluated through behavioral tests. Nissl staining and Bielschowsky silver staining were employed to examine neuronal damage and axonal loss, and immunofluorescence was used to assess axonal regeneration. The expression of key proteins in the Rho/ROCK signaling pathway was analyzed by Western blotting (WB) and quantitative real-time PCR (qRT-PCR). CG treatment significantly reduced infarct volume, promoted axonal regeneration, improved neurological outcomes, and modulated the expression of RGMa, Rho, ROCK, and CRMP2. Collectively, these findings provide the first evidence that CG facilitates axonal regeneration and neurological recovery after cerebral ischemia, at least in part by inhibiting activation of the Rho/ROCK pathway, highlighting its potential as a therapeutic agent for ischemic stroke. - Source: PubMed
Publication date: 2026/05/16
Wang PengchengYu AimingLiang YingxiWang Lisheng - Ischemic stroke (IS) is a leading global cause of morbidity and mortality, with neuronal autophagy playing a pivotal role in ischemia/reperfusion (I/R) injury following stroke. Repulsive guidance molecule A (RGMa), known for its involvement in axon guidance and neuronal repair, has recently been linked to I/R injury. This study aimed to explore RGMa's role in neuronal autophagy and its therapeutic potential in mitigating I/R-induced damage using a rat model. - Source: PubMed
Publication date: 2026/05/19
Xie FeiLiang HanxiLi XiaLi JunQin Xinyue - - Source: PubMed
Publication date: 2026/04/22
Shields Christine ADeSantis DerekJonko AlexandraLee JiwooCaron Julie MPhillips Adam SFasullo John - - Source: PubMed
Publication date: 2026/03/23
Zhang GuanghuiZhang John HFeng JinzhouLi QiWu XiaohuiQin Xinyue