CD51 Polyclonal Antibody
- Known as:
- CD51 Polyclonal Antibody
- Catalog number:
- a-0495-100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Epigentek inc
- Gene target:
- CD51 Polyclonal Antibody
Related genes to: CD51 Polyclonal Antibody
- Gene:
- ITGAV NIH gene
- Name:
- integrin subunit alpha V
- Previous symbol:
- VNRA, MSK8, VTNR
- Synonyms:
- CD51
- Chromosome:
- 2q32.1
- Locus Type:
- gene with protein product
- Date approved:
- 1988-07-19
- Date modifiied:
- 2016-10-05
Related products to: CD51 Polyclonal Antibody
Related articles to: CD51 Polyclonal Antibody
- Thin endometrium (TE) is an important factor associated with embryo implantation failure and adverse pregnancy outcomes during assisted reproductive treatment. This study investigated the clinical efficacy of fixed-dose motherwort injection (MI) combined with different doses of compound estradiol/dydrogesterone tablets (CPET) in the treatment of TE, evaluated its effects on endometrial receptivity, and determined the optimal therapeutic dose of CPET. - Source: PubMed
Publication date: 2026/07/15
Wang TangxiaomanWei FangJiang JialiHe Jing - Acute respiratory distress syndrome (ARDS) is an acute respiratory failure syndrome arising from non-cardiogenic pulmonary edema, characterized by limited therapeutic options and a poor prognosis, underscoring an urgent need for effective treatments. Reduning injection (RDN) is a traditional Chinese medicine formulation widely used in clinical practice for treating respiratory tract infections. However, its specific role and underlying mechanism in ARDS remain to be fully elucidated. - Source: PubMed
Publication date: 2026/08/11
Hui Si-WenZhu Qi-MengLiu Zi-ZhouXu Xin-RongZhang Hui-LinChang JingJia Ya-XueQiu FengGuo Shan-ShanZhang JuanSun Cheng-Peng - This study explored the genetic evidence linking triglyceride-related pathways and lipid-lowering drug targets with endometriosis risk and investigated the genetic association between TG levels and EM. Using genome-wide association study (GWAS) data, a two-sample Mendelian randomization (MR) analysis was conducted, estimating the association between genetically predicted TG levels and EM risk (OR = 1.1853, 95% CI: 1.070-1.313, p = 0.0011). Seven TG-lowering drug target genes (SLC9A1, SCN3A, VEGFA, APOA1, TNF, ITGAV, BACE1) were identified. Transcriptome analysis revealed that SCN3A, BACE1, and APOA1 were significantly upregulated in EM patients compared to healthy controls. Enrichment pathway analysis showed that these genes are involved in lipid transport, localization, cell adhesion, and blood vessel development. PPARA was predicted to act as a transcription factor for five of these genes, while estrogen receptor 1 (ESR1) was predicted to regulate the majority of the others. Among the TG inhibitors examined, fibrate-related targets showed relatively broader target coverage in the present genetic analyses. These findings suggest that TG-related pathways and lipid-lowering drug targets, particularly fibrate-related targets, may be relevant to EM biology and warrant further experimental and clinical validation. - Source: PubMed
Publication date: 2026/08/13
Li YonghongHe JiananZhang YuanqingYang MinJia ZhimaoFan YidanLiu ShuyunQi Mengsha - Microglia play a key role in the pathophysiology of Alzheimer's Disease (AD) and their increased heterogeneity likely affects disease progression. We previously identified distinct microglial signatures that were enriched in AD donors and associated with amyloid and tau, respectively. Here we generated a snRNAseq dataset from postmortem control and AD cases and analyzed alterations in cell-cell communication pathways that might be relevant to AD pathophysiology. One signaling pathway perturbed in AD cases involved SPP1, and while this pathway was also present in control samples, microglia-microglia SPP1 signaling was restricted to AD donors. Further analyses within microglia-microglia signaling predict AD-specific induction of GAS6-AXL signaling (from inflammatory and ribosomal microglia), and SPP1-ITGAV/ITGB5 signaling (from disease-associated and inflammatory microglia, among others). Together, these findings might in part explain the increased microglia phagocytic profile described in AD. RNAscope confirmed enrichment of SPP1 expressing microglia near amyloid plaques in AD brain tissue samples. These data indicate altered cellular communications between microglia in the AD brain. - Source: PubMed
Kotah Janssen MLima Marina TrombettaDragt Esmée CVoulgaroglou AsimeniaBrouwer NieskeHoltman Inge RKooistra Susanne MEggen Bart J L - BackgroundMesenchymal stem cell (MSC)-derived endothelial-like cells exhibit enhanced angiogenic potential compared with undifferentiated MSCs. However, the role of N6-methyladenosine (m6A) RNA modification in MSC endothelial differentiation remains unclear.MethodsHuman bone marrow-derived MSCs were isolated and induced toward an endothelial phenotype using cytokine-enriched medium. Endothelial differentiation was evaluated using flow cytometry, western blotting, immunofluorescence staining, tube formation assays, and Dil-Ac-LDL uptake assays. MeRIP-seq and RNA-seq were performed to profile transcriptome-wide m6A methylation and gene expression changes. Bioinformatics analyses, including GO enrichment, KEGG pathway analysis, and protein-protein interaction (PPI) network construction, were conducted to identify key regulatory genes and pathways.ResultsFollowing induction, MSCs exhibited endothelial characteristics, including increased expression of CD31 and CD34, enhanced tube formation ability, and increased Dil-Ac-LDL uptake. Transcriptome-wide analysis identified 16,355 differentially methylated peaks and 2,732 differentially expressed genes, including 1,204 differentially methylated and expressed genes (DMEGs). Functional enrichment analysis revealed that DMEGs were mainly associated with extracellular matrix organization, endothelial differentiation, and cell adhesion. PPI network analysis identified a highly interconnected module, and integrin family genes (ITGA1, ITGAV, ITGA11, ITGB5) and ADAMTS2 were identified as key hub genes.ConclusionsThis study provides a transcriptome-wide landscape of m6A methylation during endothelial differentiation of BM-MSCs and identifies key regulatory pathways and hub genes potentially involved in this process. These findings suggest that m6A-mediated epitranscriptomic regulation plays an important role in MSC endothelial differentiation and angiogenesis. - Source: PubMed
Publication date: 2026/07/25
Yao ZipingZhang BihuiZou YinghuaTong XiaoqiangYan ZiguangNiu GuochenLi YuanYang Min