c-Jun Polyclonal Antibody
- Known as:
- c-Jun Polyclonal Antibody
- Catalog number:
- a-0470-100
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- Epigentek inc
- Gene target:
- c-Jun Polyclonal Antibody
Related products to: c-Jun Polyclonal Antibody
Related articles to: c-Jun Polyclonal Antibody
- Small-quantity lipid-based nutrient supplements (SQ-LNS) have been shown to improve growth, development, and survival among young children in low-resource settings. One hypothesized pathway is through improvements in intestinal health, including modulation of the gut microbiome and reductions in environmental enteric dysfunction (EED). This study examined the effects of SQ-LNS on the gut microbiome and markers of EED and systemic inflammation among young children in Lusaka, Zambia. We conducted intention-to-treat analyses of 302 children aged 27-35 months in a 2x2 cluster-randomized trial. Serum biomarkers of EED (soluble CD14, intestinal fatty acid binding protein) and inflammation (alpha-1-acid glycoprotein, C-reactive protein) were assessed in 240 children via the Multiple-Micronutrient and Environmental Enteric Dysfunction Assessment Tool (MEEDAT). Differences by SQ-LNS assignment were assessed using unadjusted and adjusted ordinary least squares regression models. Rectal swab samples from 299 children underwent 16S rRNA gene sequencing. Taxonomic profiles were visualized using stacked bar plots, alpha diversity was quantified using Shannon diversity indices, and beta diversity was assessed using non-metric multidimensional scaling based on Bray-Curtis dissimilarity matrices. We found that SQ-LNS had no significant effect on EED or inflammation biomarkers and was not associated with differences in gut microbiome alpha diversity, beta diversity, or overall microbial community composition. In exploratory analyses, abundance was lower among children receiving SQ-LNS. Overall, 18 months of SQ-LNS supplementation was not associated with broad changes in intestinal health among young Lusakan children. These findings suggest that the benefits of SQ-LNS operate through pathways other than intestinal health, such as improved nutrient availability. - Source: PubMed
Publication date: 2026/06/22
Lauer Jacqueline MLeng YaoanChembe MpelaHenderson SavannaParkerson DougChibesa KennedyMoono AndrewFink GüntherRockers Peter CLocks Lindsey M - Data scarcity limits the characterization of protein fitness landscapes and the development of accurate variant effect prediction models. To address this challenge, we introduce fitness translocation, a data augmentation strategy that generates synthetic variants for a target protein by leveraging variant fitness data previously measured in homologous proteins. Using embeddings from protein language models, the method computes the difference between each homolog variant and its wild type and applies these offsets to the target wild-type embedding to create synthetic variants in embedding space. - Source: PubMed
Publication date: 2026/06/20
Mialland AdrienFukunaga ShuzoKatsuki RikuDong YunfeiYamaguchi HidekiSaito Yutaka - Infectious Spleen and Kidney Necrosis Virus (ISKNV) is a significant fish pathogen historically reported in East and Southeast Asia and increasingly detected in other regions, often in association with the international movement of ornamental fish. Centrocestus formosanus is a digenean trematode of sanitary and economic relevance, with zoonotic potential, that uses snails and fish as intermediate hosts. In this study, ornamental fish representing 24 species were sampled from 13 quarantine facilities across Chile. ISKNV was detected in samples of platy fish (Xiphophorus maculatus) from two quarantine facilities in the Metropolitana district in Chile, both supplied by the same exporter in the State of Florida (United States). C. formosanus metacercariae were also detected in the gills of two ISKNV-positive platy fish. These results represent the first molecular detection of ISKNV and C. formosanus in ornamental fish in Chile and highlight the relevance of targeted surveillance for high-risk pathogens in imported ornamental fish. - Source: PubMed
Publication date: 2026/06/21
Solano-Iguaran Jaiber JPontigo FelipeCisterna DennisAnguita CarlaGonzález-Gómez Margarita P - Microorganisms with health-promoting potential often experience substantial losses in viability and function due to stresses encountered during manufacturing and gastrointestinal transit. In this study, we investigate whether biofilm can be leveraged to enhance microbial resilience and functional performance. Using as a model biofilm-forming bacterium, we examined strains with defined biofilm phenotypes: a biofilm-deficient mutant (), a biofilm-overproducing mutant (), and an isogenic wild-type control. These strains were evaluated across multiple functional benchmarks, including survival in simulated gastric and bile juices, thermotolerance, and intestinal bacterial colonization in the model. Commercially available strains GG and were included as reference comparators. The biofilm-overproducing strain demonstrated markedly enhanced survival under simulated gastrointestinal conditions and showed increased colonization within the intestine. In contrast, the biofilm-deficient mutant exhibited severe sensitivity to gastric stress and reduced the intestinal bacterial load. Furthermore, we demonstrate that cell-free biofilm can function as an effective bioencapsulation matrix. When used to encapsulate multiple probiotic strains, the biofilm matrix significantly improved their survival under acidic gastric conditions by neutralizing the environmental pH, indicating its broad potential for probiotic formulations and targeted gastrointestinal delivery. Overall, biofilms are traditionally studied for their roles in infection and antimicrobial resistance; however, their protective and adaptive traits may be repurposed for beneficial use. As an example of this concept, our findings show that biofilms enhance multiple functional and technological traits and highlight biofilm-based strategies as a promising platform for improving beneficial microbial robustness and the delivery of live biotherapeutics. - Source: PubMed
Publication date: 2026/06/21
Kunyeit LohithRao Reeta - Novel stent technologies offer early intravascular treatment options for coarctation (COA). Mid-to-long-term cardiovascular responses to early COA stent interventions are undefined. - Source: PubMed
Publication date: 2026/06/21
Gober Leah MStellon Michael ACulver Matt AFrenkel AmyIrrer DanaWitzenburg Colleen MRoldán-Alzate AlejandroLamers Luke