COPS2 Antibody
- Known as:
- COPS2 Antibody
- Catalog number:
- csb-pa005789esr1hu
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- CusAb
- Gene target:
- COPS2 Antibody
Related genes to: COPS2 Antibody
- Gene:
- COPS2 NIH gene
- Name:
- COP9 signalosome subunit 2
- Previous symbol:
- -
- Synonyms:
- TRIP15, ALIEN, CSN2
- Chromosome:
- 15q21.2
- Locus Type:
- gene with protein product
- Date approved:
- 2004-11-03
- Date modifiied:
- 2014-11-19
Related products to: COPS2 Antibody
Related articles to: COPS2 Antibody
- Deep vein thrombosis (DVT) is a life-threatening condition in which dysregulated immune-endothelial interactions drive thrombus formation, yet upstream molecular regulators remain poorly understood. Employing an integrative multi-omic strategy - combining proteome-wide Mendelian randomization, immune cell mediation analysis, bulk and single-cell transcriptomics, and machine learning - we identified 132 plasma proteins with genetically inferred causal effects on DVT. Among these, COP9 signalosome subunit 2 (COPS2) emerged as the most consistent candidate, with approximately 20% of its effect mediated through effector memory cluster of differentiation 8-positive (CD8) T cells. Transcriptomic profiling localized COPS2 expression to CD8 T cells and endothelial cells, and functional validation in endothelial cells demonstrated that COPS2 directly upregulates tissue factor (TF), intercellular adhesion molecule-1 (ICAM-1), and Bcl-2-associated X protein (BAX), enhances procoagulant activity, and activates the Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling pathway. Machine learning models consistently identified COPS2 as a robust diagnostic feature across independent cohorts. , Cops2 deficiency reduced thrombus burden, attenuated activation of effector memory CD8 T cells, and decreased intrathrombotic levels of interferon-gamma (IFN-γ) and granzyme B (GZMB). These findings establish COPS2 as a key regulator of immune-endothelial crosstalk in DVT and highlight its potential as a biomarker and therapeutic target. - Source: PubMed
Publication date: 2026/05/15
Chen YuanqiWu JijunPeng JiaweiBai YiduoLiu WenjunLiu HaoZhang Zilang - Keel length is a key body size indicator, which has an important impact on the overall growth performance, bone health, and production performance of poultry. In the process of selecting crossed strains for yellow feathered broiler chickens, it is generally necessary to select keel length, but there is little research on keel length development. Therefore, resequencing and GWAS was employed to obtain SNP molecular markers associated with keel length in a specialized Yellow-feathered broiler line. We identified 10 SNPs that were potentially significantly correlated with keel length for the first time located at 9 genes, including ATP7B, CST3, OTOP1, CRMP1, SLC12A1, COPS2, FAM227B, IFT140, APLP2. SNP2 and SNP3 loci were in a strongly linked state (D ' value=1), the other 8 SNP loci were not in a strongly linked state (D 'value<1). The association analysis between single SNP marker and keel length traits showed that TT and CT at SNP1 (rs315701680), GG at SNP2 (rs738740137), AA at SNP3 (rs317223723), AA at SNP4 (rs732443622), GG at SNP5(rs315667756), CC at SNP6 (rs314381113), GG at SNP7 (rs732811384), TT at SNP8 (rs314197610), CC and TC at SNP9 (rs13782000), TT and GT at SNP10 (rs737401141) genotypes were all the dominant genotypes for keel length. The strong linkage between SNP2 and SNP3 resulted in two haplotypes H1 (AG) and H2 (GA), respectively. The H1H1 haplotype (GGAA) produced by SNP2 and SNP3 linkage was the dominant genotype for keel length. The SNP molecular markers and dominant genotypes at SNP1-SNP10 loci identified in this study may be used to improve the accuracy and genetic progress of keel length selection. Meanwhile, candidate genes potentially significantly related to keel length will lay the foundation for genetic selection of keel length and cultivation of high-quality yellow feathered broilers in the future. - Source: PubMed
Publication date: 2026/03/27
Tu Y JLiu Y FZhang MJu X JShan Y JJi G GShu J T - Autophagy serves as a cellular defense against pathogens, while viruses exploit it through evolutionary arms races. Here, using Classical Swine Fever Virus (CSFV), an enveloped RNA pestivirus threatening global swine industries, we uncover a biphasic autophagy-hijacking strategy coordinated by COP9 signalosome subunit 2 (COPS2). Mechanistically, CSFV hijacks COPS2-mediated K11/K48-linked ubiquitination of viral P7 protein to create an autophagy recognition signal and facilitate virus entry into autophagosomes. In addition, COPS2 drives STX17-SNAP29-VAMP8 complex assembly by inhibiting SNAP29 O-GlcNAcylation, accelerating autophagosome-lysosome fusion to generate exocytosis-competent autolysosomes for viral release. This spatiotemporal regulation enables non-lytic viral propagation via autolysosomal exocytosis. Our study provides the first evidence that RNA viruses commandeer both ends of the autophagy machinery for complete replication cycles, identifying COPS2 as a master coordinator of autophagic flux hijacking and revealing the COPS2-SNAP29 axis as a conserved therapeutic target against enveloped RNA viruses. - Source: PubMed
Publication date: 2025/11/19
Wu KekeLi BingkeZhao RuiboBai YeZeng SenDing HongxingYi LinFan ShuangqiChen Jinding - Intervertebral disc degeneration (IVDD) is a primary cause of chronic low back pain, significantly impacting quality of life and healthcare systems globally. Despite its prevalence, the molecular mechanisms underlying IVDD remain unclear, and effective biomarkers are lacking. This study aims to identify circulating protein biomarkers causally linked to IVDD and explore their potential as biomarkers. - Source: PubMed
Publication date: 2025/07/31
Bai FanWang LingtingLiu HeHe YufeiWang Hong - Previous studies have demonstrated a close association between neddylation modifications and tumor progression as well as alterations in the microenvironment. This study aimed to explore the role of neddylation in bladder cancer (BLCA) progression and its prognostic significance. - Source: PubMed
Publication date: 2025/06/16
Xiaolong HuangMin DengSizhou ZhangDaorong HuJuncheng PanYanjian WangHong Li Jie GuJi ZhengQingjian Wu