CKMT2 Antibody
- Known as:
- CKMT2 Antibody
- Catalog number:
- csb-pa005462esr2hu
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- CusAb
- Gene target:
- CKMT2 Antibody
Related genes to: CKMT2 Antibody
- Gene:
- CKMT2 NIH gene
- Name:
- creatine kinase, mitochondrial 2
- Previous symbol:
- -
- Synonyms:
- SMTCK
- Chromosome:
- 5q14.1
- Locus Type:
- gene with protein product
- Date approved:
- 1992-10-14
- Date modifiied:
- 2015-11-26
Related products to: CKMT2 Antibody
Related articles to: CKMT2 Antibody
- Seasonal crude protein (CP) and phosphorus (P) deficiency in northern Australian pastures reduces feed intake and growth of grazing ruminants, but the hepatic mitochondrial mechanisms underlying this response remain unclear. We characterized the hepatic mitochondrial transcriptome of sheep exposed to CP-P deficiency or matched-intake feed restriction. Merino wethers were assigned for 63 d to one of three treatments ( = 8/group): High CP-P, Low CP-P, or Restricted, in which High CP-P feed was offered at the same energy intake as the Low CP-P group. Liver RNA was sequenced, and transcripts encoding mitochondrial proteins were identified using MitoCarta 3.0. Differentially expressed genes (DEGs) were defined as adjusted < 0.05 and |log2FC| ≥ 0.585. Of 804 mitochondrial genes detected, 83 were differentially expressed in at least one pairwise comparison. The greatest transcriptional response occurred in contrasts against High CP-P (Low CP-P vs. High CP-P: 38 DEGs in 8 enriched pathways; Restricted vs. High CP-P: 37 DEGs in 10 enriched pathways). In both low-intake treatments, , , , and were upregulated, suggesting altered folate-mediated one-carbon metabolism. Restricted sheep also showed higher expression of several transporters (, , , , and ), indicative of enhanced mitochondrial nucleotide and metabolite exchange under CP-P adequate energy restriction. In contrast, Low CP-P sheep showed higher expression of and relative to either High CP-P or Restricted sheep, a nutrient-deficiency specific transporter response. expression was also higher in Restricted sheep than in both other groups. These findings suggest that reduced metabolizable energy intake was associated with the bulk of the hepatic mitochondrial transcriptional response, particularly in folate-mediated one-carbon metabolism, whereas CP-P deficiency was associated with a smaller but distinct transporter signature. The liver mitochondrial transcriptome may provide mechanistic insight into nutritional adaptation under CP and P deficiency in grazing sheep. - Source: PubMed
Publication date: 2026/05/31
Fernandez Elmer EInnes David JBottje Walter GFortes Marina R SPoppi Dennis PQuigley Simon PBond Jude JHudson Nicholas J - Osteosarcoma (OS) is the most common primary malignant bone tumor. Intratumoral heterogeneity (ITH) contributes to therapy resistance and disease spread. Understanding the molecular structure and cellular groups contributing to ITH, as well as their clinical impacts, remains limited. - Source: PubMed
Publication date: 2026/05/25
Li XuesongLi GuanghaoPeng TianchouQiu JunjunLi ShengweiWang JingfuZhang Jin - The function of long non-coding RNAs (lncRNAs) in osteoarthritis is increasingly recognized. CKMT2-AS1 has been reported to be dysregulated in osteoarthritis, but its biological function remains unknown. - Source: PubMed
Publication date: 2026/06/01
Zhang YangLiu XiangyunHao XintongXu HaitaoZhu Xingyu - Loss of cardiomyocytes during hypoxia-reoxygenation injury contributes to adverse myocardial remodeling, resulting in hypertrophy of surviving cardiomyocytes, interstitial fibrosis, and ultimately, heart dysfunction. Despite extensive research in the field, there is currently no specific treatment available for myocardial hypoxia-reoxygenation injury to prevent cardiomyocyte death. Prenylcysteine oxidase 1 (PCYOX1) is a pro-oxidant, FAD-dependent thioether oxidase that generates hydrogen peroxide during prenylcysteine metabolism, but its role in cardiomyocytes is poorly defined. Here, using HL-1 cardiomyocytes stably silenced for Pcyox1, we show that PCYOX1 contributes to both basal and stress-induced oxidative burden and cell death. Pcyox1 silencing reduced reactive oxygen species (ROS) levels at baseline and blunted the ROS increase during ischaemic/hypoxic stress. Consistently, Pcyox1 silencing decreased apoptosis after prolonged ischaemic/hypoxic exposure. Quantitative proteomics of whole-cell lysates and isolated mitochondria revealed coordinated remodeling of pathways involved in energy buffering and contractile machinery, including increased abundance of mitochondrial creatine kinases (CKMT1/CKMT2), acetyl-CoA synthetase 2-like (ACSS1), and multiple myosin components, changes that persisted under ischaemic/hypoxic stress and after reoxygenation. Overall, these data identify PCYOX1 as a modulator of redox homeostasis and proteomic adaptation in cardiomyocytes and support PCYOX1 inhibition as a potential strategy to limit hypoxia-reoxygenation-associated injury. - Source: PubMed
Banfi CristinaBrocca LisaBascucci AlicePapaianni Giulia GiusyMallia AliceEligini Sonia - Colorectal cancer (CRC) remains a major cause of cancer-related morbidity and mortality, with high recurrence rates and limited treatment options for metastatic disease. The tumor microenvironment (TME) and metabolic reprogramming are critical drivers of CRC progression, influencing immune responses, therapeutic resistance, and patient outcomes. - Source: PubMed
Publication date: 2026/03/09
Fu YuxiangLai JianboHuang KaibinLiu LipingLiao Guixiang