ALDH1A2 Antibody
- Known as:
- ALDH1A2 Antibody
- Catalog number:
- csb-pa001566esr1hu
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- CusAb
- Gene target:
- ALDH1A2 Antibody
Related genes to: ALDH1A2 Antibody
- Gene:
- ALDH1A2 NIH gene
- Name:
- aldehyde dehydrogenase 1 family member A2
- Previous symbol:
- -
- Synonyms:
- RALDH2
- Chromosome:
- 15q21.3
- Locus Type:
- gene with protein product
- Date approved:
- 2001-03-30
- Date modifiied:
- 2018-05-03
Related products to: ALDH1A2 Antibody
Related articles to: ALDH1A2 Antibody
- Spermatogenesis is a highly coordinated biological process in which diploid spermatogonia undergo mitotic expansion, meiotic division, and terminal differentiation into haploid spermatozoa. This process is tightly regulated by intrinsic germ cell programs and extrinsic signals from Sertoli cells within the seminiferous epithelium. Among the signaling pathways governing male germ cell development, all-trans retinoic acid (RA), a bioactive metabolite of vitamin A, has emerged as a master regulator of meiotic initiation and spermatogonial differentiation in mammals. RA functions through nuclear retinoic acid receptors (RARs) and retinoid X receptors (RXRs), which regulate transcriptional networks essential for germ cell progression, including the activation of Stimulated by Retinoic Acid 8 (), a key determinant of meiotic entry. Intratesticular RA homeostasis is maintained by a balance between synthesis via aldehyde dehydrogenase (ALDH) enzymes and degradation by cytochrome P450 family 26 (CYP26) enzymes, ensuring precise temporal and spatial control of germ cell development. While rodent models have defined core mechanisms of RA signaling, the canine testis provides a valuable comparative and translational system due to its physiological similarity to human spermatogenesis and relevance to reproductive management. Recent studies highlight conserved RA signaling pathways in dogs, including receptor-mediated transcriptional regulation, feedback control of RA metabolism, and post-transcriptional modulation via microRNAs. Importantly, pharmacological manipulation of RA signaling can reversibly disrupt spermatogenesis, supporting its potential applications in non-hormonal male contraception. This review integrates molecular, developmental, pharmacological, and comparative evidence and presents RA signaling as a central regulatory axis of spermatogenesis with important translational applications. - Source: PubMed
Publication date: 2026/06/14
Kasimanickam VanmathyKasimanickam Ramanathan - Human pluripotent stem cells (hPSCs) can be used as a scalable source of lymphocytes for adoptive cell therapies, contingent on the robust generation of definitive hematopoietic intermediates. Early WNT activation with CHIR99021 during mesoderm induction promoted the formation of KDR+ ALDH1A2+ mesoderm, which is essential for subsequent generation of T cells in a retinoic acid (RA)-dependent manner. Integrated scRNA-seq and ATAC-seq defined a WNT-dependent developmental trajectory from hPSCs to KDR+ ALDH1A2+ mesoderm. Gene regulatory network modeling predicted HDAC2 and E-box transcription factors as regulators of RA-responsive mesodermal differentiation downstream of WNT. HDAC2 knockout impaired, while HDAC2 overexpression enhanced KDR+ ALDH1A2+ mesoderm formation. E-box factor manipulation had no discernible effect. An orthogonal chemical screen confirmed that HDAC2 inhibition suppressed KDR+ ALDH1A2+ mesoderm, whereas modulating histone methylation enhanced their formation. These findings reveal mechanisms by which WNT signaling promotes RA-responsive mesoderm, and they suggest methods to improve the generation of lymphocytes from hPSCs. - Source: PubMed
Publication date: 2026/06/18
Thai Bao QSargent Elizabeth JLuff Stephanie AFields Colin AChurko Jared MYoung Jonathan NBosco AnthonySturgeon Christopher MBhattacharya Deepta - Elevated cholesterol levels are associated with the risk of the most socially significant cardiovascular diseases, such as atherosclerosis, ischemic heart disease, and myocardial infarction. - Source: PubMed
Publication date: 2026/06/02
Mamchur AleksandraBruttan MariaDaniel VeronikaKashtanova DariaZelenova ElenaDzhumaniiazova IrinaIvanov MikhailMatkava LorenaBlinova OlgaMitrofanov SergeyGolubnikova LiliyaKumar NaianaMaralova EkaterinaShingaliev AndreyEzhov MaratMeshkov AlekseyChubykina UlianaPogorelova OlgaTripoten MariiaBalahonova TatyanaViskova AlexandraKomarova MadinaGurtsiev TimurGomyranova NataliaVorobeva YuliaHotuleva AnastasiaKolyaskina MariaYudin VladimirMakarov ValentinKeskinov AntonKuzmina LyudmilaBoytsov SergeyYudin SergeySkvortsova Veronika - Ménière disease (MD) is a chronic inner ear disorder characterized by recurrent vertigo, fluctuating sensorineural hearing loss, and tinnitus, but its etiology remains poorly understood. We performed a genome-wide meta-analysis of 8,969 MD case subjects and 1,962,542 control subjects across five biobanks, identifying five independent genome-wide significant loci and estimating an observed-scale SNP heritability of 7% (SE 0.8%), indicating a modest but significant contribution of common genetic variation to MD risk. The genome-wide significant signals comprise two independent variants at EYA4, two at EYA1, and one near CYP26A1, with odds ratios between 1.1 and 1.25. Associations at two additional loci, LMO4 and ALDH1A2, fell just below the genome-wide significance threshold (5 × 10 Publication date: 2026/06/16
Shi ZhuozhengMandla RaviLi JingjingLi XinzheZhang Zixuan EleanorChen SixingLapinska SandraFlynn-Carroll Alexander OPasaniuc BogdanEpstein Douglas JMathieson Iain - Excessive abdominal fat deposition reduces production efficiency and metabolic health, whereas yolk lipid content is directly linked to egg quality and reproductive output. These two fat-related traits are often in conflict from a breeding perspective, yet whether they share common genetic and molecular determinants-and whether such sharing could inform divergent selection for lean abdomen with lipid‑rich yolk-remains unclear. Here, we analyzed 22 fat deposition-related traits in a population of 248 laying hens, together with genome-wide genotyping data, transcriptomic data from 10 tissues. Our results showed marked heterogeneity in the genetic architecture of fat deposition-related traits, with a higher degree of signal sharing among biologically related traits but limited overlap across different trait categories. Multi-trait association and trait-trait colocalization analyses further identified multiple shared loci between abdominal fat-related (AF) and egg yolk-related (EY) traits, including several shared candidate signals on chromosomes 2, 10, and 11. Integrative analyses incorporating multi-tissue cis-eQTL data further prioritized shared candidate regulatory genes, including MYO10, GPT2, VPS35, ADAM10, ALDH1A2, and MYO1E. Representative AF-EY shared loci, including 2__74614272, rs318039150, and rs741038415, showed opposite effect tendencies between abdominal fat- and yolk-related traits, whereas loci involving ADAM10, ALDH1A2, and MYO1E showed more directionally consistent associations, indicating both potential antagonistic and coordinated regulatory relationships. Together, these findings reveal a complex shared molecular basis linking abdominal fat deposition and yolk lipid deposition during the extended laying period and provide a framework for dissecting coordinated regulatory mechanisms and informing molecular breeding in laying hens. - Source: PubMed
Publication date: 2026/05/27
Zhang WenxinLan FangrenCai RonglangYang NingSun Congjiao