C1QTNF3 Antibody
- Known as:
- C1QTNF3 Antibody
- Catalog number:
- csb-pa003648la01hu
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- CusAb
- Gene target:
- C1QTNF3 Antibody
Related genes to: C1QTNF3 Antibody
- Gene:
- C1QTNF3 NIH gene
- Name:
- C1q and TNF related 3
- Previous symbol:
- -
- Synonyms:
- CTRP3, Cors, Corcs, 2310005P21Rik, Cors-26
- Chromosome:
- 5p13.2
- Locus Type:
- gene with protein product
- Date approved:
- 2001-10-02
- Date modifiied:
- 2017-03-01
Related products to: C1QTNF3 Antibody
Related articles to: C1QTNF3 Antibody
- Basement membrane-related genes (BMRGs) play a pivotal role in the pathogenesis of several diseases. However, their association with coronary artery disease (CAD) remains unexplored. Therefore, this investigation is designed to elucidate the involvement of BMRGs in CAD mechanisms. - Source: PubMed
Dong ZhaoZhang YuyuLi ZhuangYu HaozhenGe Wei - Exercise-induced secreted factors (exerkines) are proposed to coordinate systemic health benefits, yet their human tissue sources and the physiological rules governing transcript-to-serum coupling remain incompletely defined. We integrated multi-tissue transcriptomics with matched serial serum profiling to identify exercise-regulated exerkines and determine whether tissue mass moderates their systemic appearance. Sixteen healthy, sedentary young men performed a single treadmill bout calibrated to expend 300 kcal at 70-75% of maximum heart rate. RNA sequencing was performed on periumbilical subcutaneous adipose tissue, vastus lateralis skeletal muscle and whole blood collected before and immediately after exercise, with serial serum quantification up to 120 min post-exercise. Acute exercise altered adipose and muscle transcriptomes, with a minimal whole-blood response, and upregulated LGALS1 (galectin-1), FSTL1 (follistatin-like 1), OGN (osteoglycin) and C1QTNF3 (C1q and tumour necrosis factor-related protein 3) in both tissues. Serum follistatin-like 1 and galectin-1 concentrations increased significantly immediately after exercise and during recovery. Despite robust transcript induction, OGN and C1QTNF3 did not translate into early circulating increases, indicating candidate-specific kinetics and constraints beyond transcript abundance. Moderation models revealed divergent transcript-to-serum coupling: follistatin-like 1 coupling was moderated by tissue mass in both muscle and adipose depots, whereas galectin-1 followed a muscle-dominant additive profile independent of mass scaling. These findings propose galectin-1 and follistatin-like 1 as human exerkines and indicate that body composition regulates systemic exerkine signatures after exercise, providing a mechanistic framework for understanding physiological variability in exercise-induced adaptations. KEY POINTS: Exercise releases circulating factors that may contribute to health benefits, but the human tissues responsible for their production remain unclear. RNA sequencing was performed in human skeletal muscle, subcutaneous adipose tissue and whole blood, with targeted serum protein quantification over 2 h after a single treadmill bout. Exercise increased LGALS1 and FSTL1 transcripts in skeletal muscle and adipose tissue, with concurrent increases in their circulating protein products immediately post-exercise and during recovery, whereas OGN and C1QTNF3 transcripts increased robustly without an early post-exercise elevation in their circulating protein products. Body composition moderated transcript-to-serum coupling: FSTL1 (follistatin-like 1) showed mass-sensitive coupling, whereas LGALS1 (galectin-1) displayed a muscle-dominant additive profile. Galectin-1 and follistatin-like 1 emerge as exercise-induced exerkines whose circulating responses vary with body composition, supporting their prioritization as candidate mediators of exercise-related health benefits and a framework for interpreting physiological heterogeneity in adaptation. - Source: PubMed
Publication date: 2026/05/15
Song JaeseungCho Eun-SukKwon Yu RimPark Jong SukNam Ji SunKim YuSik - Adoptive transfer of tumor-infiltrating lymphocytes (TIL) is effective in melanoma and selected solid tumors, but its potential in pancreatic ductal adenocarcinoma (PDAC) remains largely unexplored. We report a 39-year-old male with metastatic PDAC involving lung, peritoneal, liver, and lymph node who received three sequential infusions of TIL expanded ex vivo with IL-2/IL-15/IL-21 from a lung metastasis. Each infusion followed low-dose lymphodepletion and IL-2 support. The patient achieved stable disease after the first infusion and a partial response after the second along with reductions in serum CA19-9. Genome sequencing revealed substantial inter-tumoral heterogeneity, with mutations in ITGB2, C1QTNF3, CDK9, TMEM200C, FHOD1 and ZZZ3 impacting TIL infiltration and clinical response. RNA-seq showed that responding lesions were enriched for inflammatory and tumor-specific programs, displayed enrichment of T-cell activation transcripts and had reduced infiltration of cancer-associated fibroblasts. TCR sequencing confirmed the robust infiltration of TIL-derived CD8+ clonotypes, while functional assays demonstrated a polyclonal recognition of patient-derived somatic mutations and cytotoxicity against autologous tumor lines. Single-cell TCR mapping further validated the dominance of tumor-specific CD8+ clonotypes in responding lesions. This case demonstrates the feasibility and immunological activity of TIL therapy in PDAC, while underscoring the impact of spatial tumor heterogeneity on therapeutic outcomes. - Source: PubMed
Publication date: 2026/03/04
Arruda Lucas C MKarbach JuliaKiselicki DraganSinelnikov EvgueniGustavus DirkHoffmeister HansAtmaca AkinJäger Elke - Panx3, belonging to the pannexin family of channel-forming transmembrane proteins, was previously identified predominantly expressed by bone-forming osteoblasts. Surprisingly however, only neonatal -deficient mice were found to display impaired ossification, whereas the skeleton was unaffected in adult animals. Furthermore, newborn -deficient mice displayed transient hypoglycemia, which was normalized at the age of 4 weeks, suggesting a potential role of Panx3 in linking glucose metabolism to bone growth. As bone regeneration largely recapitulates endochondral ossification during skeletal development, and as both processes require substantial amounts of energy, in the present study we investigated the role of Panx3 in fracture healing using a femoral osteotomy model. - Source: PubMed
Publication date: 2026/03/19
Jiang ShanBaranowsky AnkeLuther JuliaO'Donnell Brooke LWakefield BrentBassen ClaraNeven MonaEis-Janzyk GesineAmling MichaelPenuela SilviaSchinke ThorstenKeller Johannes - This study analyzed the correlation between serum C1q/TNF-related protein 3 (CTRP3) and cystatin C (CysC) and glucose-lipid metabolism, bone mineral density (BMD), and bone metabolism markers in elderly patients with type 2 diabetes mellitus (T2DM) complicated with osteoporosis (OP). - Source: PubMed
Publication date: 2026/03/06
Wang Yi-PengWang YongChen TaoChen GangYang Ze-Yu