FAM110B Antibody
- Known as:
- FAM110B Antibody
- Catalog number:
- csb-pa008005la01hu
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- CusAb
- Gene target:
- FAM110B Antibody
Related genes to: FAM110B Antibody
- Gene:
- FAM110B NIH gene
- Name:
- family with sequence similarity 110 member B
- Previous symbol:
- C8orf72
- Synonyms:
- MGC39325
- Chromosome:
- 8q12.1
- Locus Type:
- gene with protein product
- Date approved:
- 2005-09-22
- Date modifiied:
- 2016-10-25
Related products to: FAM110B Antibody
Related articles to: FAM110B Antibody
- In genetics and evolutionary biology, selection signatures refer to distinct genomic patterns that reflect the action of natural and artificial selection on populations over time. Detecting such signatures provides critical insights into adaptive evolution and breed differentiation, especially in livestock populations subjected to diverse production environments and breeding objectives. In this study, a total of 96 samples were collected from four different cattle breeds, namely, South African indigenous Nguni (n = 28), Bonsmara (n = 21), Angus (n = 22), and Simmental (n = 25). The samples were genotyped using the Illumina Bovine SNP 150K BeadChip and subjected to quality control. Selection signatures were identified using the integrated haplotype score (iHS) method and the fixation index (Fst) method to assess the genetic differences between breeds. The complementary application of within-population and cross-population approaches enabled the detection of both recent and divergent selective pressures. A total of twelve regions were found to be under selection, with autosome (BTA) 12 being common between Nguni and Bonsmara. Gene annotation analyses identified several genes, including , , and in Bonsmara cattle, whereas Nguni cattle indicated potential genes such as , , and , with common between Bonsmara and Nguni on BTA 12. Cross-population analyses further identified , , and as candidate genes differentiating Bonsmara from Nguni cattle, and distinguishing Simmental from Angus cattle. These results indicated breed-specific adaptive divergence. The study revealed genomic regions that are under selection in South African Nguni, Bonsmara, and Simmental cattle, with less information for Angus cattle breeds. Several candidate genes were found to be associated with reproductive traits (such as sperm count and inseminations per conception), disease resistance (such as bovine respiratory disease), and calving ease. This study identifies breed-specific and shared genomic regions under selection across diverse cattle breeds, providing novel insights into the genetic basis of adaptation and production-related traits. These findings explain the potential application of selection signature analyses in genomic-assisted breeding programmes aimed at improving productivity, resilience, and sustainability of cattle populations. - Source: PubMed
Publication date: 2026/05/28
Modiba Mamokoma CathrineMagoro Aletta MatshidisoIdowu Peter AyodejiNephawe Khathutshelo AgreeNgcobo Jabulani NkululekoMpofu Takalani JudasMtileni Bohani - The Xinjiang Brown cattle (XJBC) is one of China's five major dual-purpose dairy and beef breeds. Analyzing the genetic diversity of the Xinjiang Brown cattle population lays the theoretical groundwork for identifying and conserving its genetic resources. This study employed the Illumina Bovine SNP 150K chip to analyze genetic diversity, inbreeding coefficient, kinship, and genetic distance in a population of 750 Xinjiang Brown cattle from three breeding farms in Xinjiang. Genetic diversity was assessed by calculating minimum allele frequency (MAF), observed heterozygosity (Ho), expected heterozygosity (He), polymorphic information content (PIC), and linkage disequilibrium (LD). Population structure was analyzed using PCA. ROH was calculated to derive ROH-based inbreeding coefficients, pedigree-based inbreeding coefficients () were estimated using CFC software for comparison, and candidate genes within high-frequency ROH regions in Xinjiang Brown cattle were identified. A G matrix was constructed to analyze population kinship. Results revealed 94,173 high-quality SNP loci in Xinjiang Brown cattle, with an average MAF of 0.276, PIC of 0.376, Ho of 0.345, and He of 0.376. Breeding farm 3 exhibited the fastest LD decay, indicating relatively high genetic diversity across Xinjiang Brown cattle populations, with farm 3 demonstrating greater diversity. The IBS genetic distance was 0.313. The G matrix results aligned with the IBS distance matrix, both indicating close kinship among some individuals within the Xinjiang Brown cattle population. The ranges for average and average across farms were 0.0017-0.0189 and 0.0609-0.0878, respectively. Short ROH segments (0.5-2 Mb) constituted the largest proportion (51.31%) of all ROHs. Within high-frequency ROH enrichment regions, 61 genes, including , , , and , were identified as potentially associated with economic traits in Xinjiang Brown cattle. These findings provide relevant marker sites for genomic selection in Xinjiang Brown cattle and lay a theoretical foundation for subsequent research. - Source: PubMed
Publication date: 2025/12/23
Ma KailunLi XueShang YanyanWei JiangjiangZhang MenghuaWang DanHuang XixiaChen QiumingXu Lei - Acute otitis media (AOM) is a prevalent pediatric infection worldwide, with mitochondrial dysfunction and immune responses implicated in its pathogenesis. However, the precise mechanisms remain elusive. - Source: PubMed
Publication date: 2025/10/22
Zi DingjingRen Xiaoyong - The present study aimed to explore runs of homozygosity (ROH), Heterozygosity Enriched Regions (HER) using the sliding window approach in both PLINK and detectRUNS, as well as the consecutive SNP approach in detectRUNS and their association with important economic traits. Genomic inbreeding coefficient based on ROH and heterosis coefficient based on HER were also estimated among crossbred (n = 81) by using GGP_HDv3_C genotyping assay. Total ROH varied from around 600 in the sliding window approach and almost double in the Consecutive SNP approach of detectRUNS. Similarly, the HER are 756 in the sliding window and 771 in the Consecutive SNP method. The mean inbreeding coefficient range varied in different approaches, i.e., 0.016-0.022 is observed based on ROH (Froh), and the heterosis coefficient based on HER (Frohet) is 0.0019. Top ROH and HER regions contain important genes related to dairy (EHHADH, CACNA1C, MICALL1, EIF3L, GTPBP1, SYNGR1, ATF4, GRAP2, FAM83F, ACO2), immunity (LIPH, TMEM41A, PEX26, CDC42EPI, CXXC5, PSD2, PURA, CYSTM1, RNF14), growth and carcass (MAGEF1, TGS1, LYN, CHCHD7, FAM110B, SDCBP, SH3BP1, GGA1, TRIOBP, PICK1, MAFF, TOMM22, MGAT3, TNRC6B, ADSL, EP300, SMDT1, MATR3) traits. These findings may provide valuable insights into the understanding of genome-wide homozygosity and heterozygosity patterns and genetic architecture of the Pakistani crossbred cattle. - Source: PubMed
Publication date: 2025/09/26
Nisa Fakhar UnUsman MuhammadAli AsadAli Muhammad BasilKaul HaibaAsif MuhammadMrode RaphaelMukhtar Zahid - Sheep have demonstrated remarkable adaptability to diverse and unproductive pastures, making them highly advantageous in the context of sustainable farming practices in the globally warming world. Despite their adaptation skills, local sheep breeds generally exhibit low performance, highlighting the need to develop desired traits. Traditional Mixed Linear Model (MLM)-based single-locus Genome-Wide Association (GWA) studies may fall short in identifying multiple loci influencing traits due to their linear genome scanning approach, rendering them less effective for detecting polygenic effects. - Source: PubMed
Publication date: 2025/08/08
Yaman YalçınAymaz RamazanKeleş MuratKişi Yiğit EmirHatipoğlu EcemÖzdemir ArzuÇetinkaya Elif