IFNA14 Antibody
- Known as:
- IFNA14 Antibody
- Catalog number:
- csb-pa011035ea01hu
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- CusAb
- Gene target:
- IFNA14 Antibody
Related genes to: IFNA14 Antibody
- Gene:
- IFNA14 NIH gene
- Name:
- interferon alpha 14
- Previous symbol:
- -
- Synonyms:
- LEIF2H, IFN-alphaH
- Chromosome:
- 9p21.3
- Locus Type:
- gene with protein product
- Date approved:
- 1993-01-14
- Date modifiied:
- 2016-10-05
Related products to: IFNA14 Antibody
Related articles to: IFNA14 Antibody
- The association between the expression of type I interferon related genes (TIIRGs) and EFrHF is not well understood. This study aimed to investigate the correlation between the expression patterns of TIIRGs and EFrHF using bioinformatics analysis. - Source: PubMed
Zhuo JianfengZhong YanLuo XiaojuanQiu SijieLi XinmeiLiang YunyuWu YuZhang Xiyu - Extranodal natural killer (NK)/T-cell lymphoma (ENKTL) is prevalent in the Asian population; however, little is known about its molecular characteristics. In this study, we examined the CD30 expression in ENKTLs and then performed whole exome sequencing on ten CD30 ENKTL and CD30 ENKTL paired samples. CD30 was positive in 55.74% of the ENKTLs. Single nucleotide and insertion/deletion polymorphism analyses revealed that 53.41% of the somatic mutations in CD30 ENKTLs were shared with CD30 ENKTLs, including mutations in SERPINA9, MEGF6, MUC6, and KDM5A. Frequently mutated genes were primarily associated with cell proliferation and migration, the tumor microenvironment, energy and metabolism, epigenetic modulators, vascular remodeling, and neurological function. PI3K-AKT, cAMP, cGMP-PKG, and AMPK pathways were enriched in both CD30 and CD30 ENKTLs. Copy number variation analysis identified a unique set of genes in CD30 ENKTLs, including T-cell receptor genes (TRBV6-1 and TRBV8), cell cycle-related genes (MYC and CCND3), immune-related genes (GPS2, IFNA14, TTC38, and CTSV), and a large number of ubiquitination-related genes (USP32, TRIM23, TRIM2, DUSP7, and UBE2QL1). BCL10 mutation was identified in 6/10 CD30 ENKTLs and 7/10 CD30 ENKTLs. Immunohistochemical analysis revealed that the expression pattern of BCL10 in normal lymphoid tissues was similar to that of BCL2; however, its expression in ENKTL cells was significantly higher (67.92% vs. 16.98%), implying the potential application of BCL10 inhibitors for treating ENKTLs. These results provide new insights into the genetic characteristics of CD30 and CD30 ENKTLs, and could facilitate the clinical development of novel therapies for ENKTL. - Source: PubMed
Publication date: 2024/08/24
Zhang XiaoyingLiang KeChen HaiyanLiu LongLiu RuiruiWang ChunxueZhang Cuijuan - Monkeypox or mpox virus (mpox) is a double-stranded DNA virus that poses a significant threat to global public health security. The F3 protein, encoded by mpox, is an apoenzyme believed to possess a double-stranded RNA-binding domain (dsRBD). However, limited research has been conducted on its function. In this study, we present data on the transcriptomics and proteomics of F3L-transfected HEK293T cells, aiming to enhance our comprehension of F3L. - Source: PubMed
Publication date: 2024/02/13
Wang YihaoZhang JunzheLi MingzhiJia MengleYang LingdiWang TingWang YuKang LumeiLi MeifengKong Lingbao - Deletion of CDKN2A occurs in 50% of glioblastomas (GBM), and IFNA locus deletion in 25%. These genes reside closely on chromosome 9. We investigated whether CDKN2A and IFNA were co-deleted within the same heterogeneous tumour and their prognostic implications. We assessed CDKN2A and IFNA14 deletions in 45 glioma samples using an in-house three-colour FISH probe. We examined the correlation between p16 protein expression (via IHC) and CDKN2A deletion along with the impact of these genomic events on patient survival. FISH analyses demonstrated that grades II and III had either wildtype (wt) or amplified CDKN2A/IFNA14, whilst 44% of GBMs harboured homozygous deletions of both genes. Cores with CDKN2A homozygous deletion (n = 11) were negative for p16. Twenty p16 positive samples lacked CDKN2A deletion with some of cells showing negative p16. There was heterogeneity in IFNA14/CDKN2A ploidy within each GBM. Survival analyses of primary GBMs suggested a positive association between increased p16 and longer survival; this persisted when considering CDKN2A/IFNA14 status. Furthermore, wt (intact) CDKN2A/IFNA14 were found to be associated with longer survival in recurrent GBMs. Our data suggest that co-deletion of CDKN2A/IFNA14 in GBM negatively correlates with survival and CDKN2A-wt status correlated with longer survival, and with second surgery, itself a marker for improved patient outcomes. - Source: PubMed
Publication date: 2023/12/14
Al Shboul SofianBoyle ShelaghSingh AshitaSaleh TareqAlrjoub MoathAbu Al Karsaneh OlaMryyian AmelDawoud RandGul SinemAbu Baker ShadenBall KathrynHupp TedBrennan Paul M - The amount of SARS-CoV-2 detected in the upper respiratory tract (URT viral load) is a key driver of transmission of infection. Current evidence suggests that mechanisms constraining URT viral load are different from those controlling lower respiratory tract viral load and disease severity. Understanding such mechanisms may help to develop treatments and vaccine strategies to reduce transmission. Combining mathematical modelling of URT viral load dynamics with transcriptome analyses we aimed to identify mechanisms controlling URT viral load. - Source: PubMed
Publication date: 2023/10/18
Moradi Marjaneh MahdiChallenger Joseph DSalas AntonioGómez-Carballa AlbertoSivananthan AbilashRivero-Calle IreneBarbeito-Castiñeiras GemaFoo Cher YWu YueLiew FelicityJackson Heather RHabgood-Coote DominicD'Souza GiselleNichols Samuel JWright Victoria JLevin MichaelKaforou MyrsiniThwaites Ryan SOkell Lucy CMartinón-Torres FedericoCunnington Aubrey J