PSMA7 Antibody
- Known as:
- PSMA7 Antibody
- Catalog number:
- csb-pa01335a0rb
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- CusAb
- Gene target:
- PSMA7 Antibody
Related genes to: PSMA7 Antibody
- Gene:
- PSMA7 NIH gene
- Name:
- proteasome subunit alpha 7
- Previous symbol:
- -
- Synonyms:
- XAPC7, C6, HSPC, RC6-1
- Chromosome:
- 20q13.33
- Locus Type:
- gene with protein product
- Date approved:
- 1995-11-22
- Date modifiied:
- 2015-08-12
- Gene:
- PSMA8 NIH gene
- Name:
- proteasome subunit alpha 8
- Previous symbol:
- -
- Synonyms:
- MGC26605, PSMA7L
- Chromosome:
- 18q11.2
- Locus Type:
- gene with protein product
- Date approved:
- 2005-01-14
- Date modifiied:
- 2016-07-28
Related products to: PSMA7 Antibody
Related articles to: PSMA7 Antibody
- Proteasome experiences sophisticated dynamics in types, quantities, and activities during spermiogenesis. However, the physiological importance of proteasomal degradation in mammalian spermiogenesis remains largely unknown. Here, we report that the PSMA8-containing spermato-20S proteasome (s20S) is required for spermiogenesis and male fertility in mice. In a mutant mouse model that the C-terminal 30-amino-acid (C30) of PSMA8 is substituted by PSMA7-C30, the resulting PSMA8 protein is unstable, which further disrupts the assembly of s20S and subcellular localization of 19S regulatory particle in testes. Psma8 males could produce round spermatids, but sperm formation is delayed and abnormal, exhibiting a phenotype of oligoasthenoteratozoospermia. s20S is required for the ubiquitination-dependent proteasomal degradation of a group of proteins in elongating spermatids. These s20S-mediated degradation events are essential for liquid-liquid phase separation of FXR1 and thereby translational-activation of its substrates. Taken together, these findings provide an in vivo evidence of protein homeostasis control in spermiogenesis in mammals. - Source: PubMed
Publication date: 2026/04/13
Cao HuiwenZhang QiantingXu WeiFang AnxuanXu HaomangQiu ChengHe LugengYu Chao - Proteasomes undergo dynamic changes in their types and activities during mammalian spermatogenesis. While the spermatogenesis-specific 20S proteasome (s20S), characterized by PSMA8 substitution of PSMA7, is known to be essential for meiosis I completion, the functions of the constitutive PSMA7-containing 20S proteasomes (c20S) in spermatogenesis remain poorly understood. Here, we show that c20S proteasomes are required for the maintenance and differentiation of spermatogonia. PSMA7 is ubiquitously expressed in male germ cells beginning at the early spermatogonial stage, preceding PSMA8 expression. Conditional ablation of Psma7 using Stra8-Cre impairs proteasomal degradation in differentiating spermatogonia, leading to male infertility. Single-cell RNA sequencing analysis reveals that PSMA7-deleted germ cells are arrested at the differentiating spermatogonia stage and fail to enter meiosis. Notably, sufficient overexpression of PSMA8 restores normal spermatogenesis in Psma7-null germ cells, suggesting a potential complementarity of s20S to c20S. Therefore, our results add critical insights into the complex regulation of proteasomal degradation during spermatogenesis. - Source: PubMed
Publication date: 2025/10/28
Fang AnxuanCao HuiwenZhang YingWu JiangxuZhang QiantingXu LiangYu Chao - The complexity of breast cancer includes many interacting biological processes, and proteasome alpha (PSMA) subunits are reported to be involved in many cancerous diseases, although the transcriptomic expression of this gene family in breast cancer still needs to be more thoroughly investigated. Consequently, we used a holistic bioinformatics approach to study the genes involved in breast cancer by integrating several well-established high-throughput databases and tools, such as cBioPortal, Oncomine, and the Kaplan-Meier plotter. Additionally, correlations of breast cancer patient survival and PSMA messenger RNA expressions were also studied. The results demonstrated that breast cancer tissues had higher expression levels of genes compared to normal breast tissues. Furthermore, , , , , and showed high expression levels, which were correlated with poor survival of breast cancer patients. In contrast, and had high expression levels, which were associated with good prognoses. We also found that family genes were positively correlated with the cell cycle, ubiquinone metabolism, oxidative stress, and immune response signaling, including antigen presentation by major histocompatibility class, interferon-gamma, and the cluster of differentiation signaling. Collectively, these findings suggest that genes have the potential to serve as novel biomarkers and therapeutic targets for breast cancer. Nevertheless, the bioinformatic results from the present study would be strengthened with experimental validation in the future by prospective studies on the underlying biological mechanisms of genes and breast cancer. - Source: PubMed
Publication date: 2021/11/27
Chiao Chung-ChiehLiu Yen-HsiPhan Nam NhutAn Ton Nu ThuyTa Hoang Dang KhoaAnuraga GanggaMinh Xuan Do ThiFitriani FennyPutri Hermanto Elvira MustikawatiAthoillah MuhammadAndriani VivinAjiningrum Purity SabilaWu Yung-FuLee Kuen-HaurChuang Jian-YingWang Chih-YangKao Tzu-Jen