MP68 Antibody
- Known as:
- MP68 Antibody
- Catalog number:
- csb-pa00675a0rb
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- CusAb
- Gene target:
- MP68 Antibody
Related genes to: MP68 Antibody
- Gene:
- ATP5MPL NIH gene
- Name:
- ATP synthase membrane subunit 6.8PL
- Previous symbol:
- C14orf2
- Synonyms:
- MP68, MLQ, 6.8PL
- Chromosome:
- 14q32.33
- Locus Type:
- gene with protein product
- Date approved:
- 1999-07-22
- Date modifiied:
- 2017-11-22
Related products to: MP68 Antibody
Related articles to: MP68 Antibody
- Spinal cord injury (SCI) is a major global health issue with severe complications, yet effective biomarkers remain elusive. We analyzed the GSE226238 dataset from the Gene Expression Omnibus (GEO) database and identified 4621 differentially expressed genes (DEGs) between SCI and controls, comprising 2684 upregulated and 1577 downregulated genes. Functional enrichment analyses revealed these DEGs are predominantly involved in protein degradation pathways, immune-related processes and ubiquitin-mediated proteolysis. Immune infiltration analysis using multiple algorithms showed significant alterations in B cells, T cells, NK cells and neutrophils, indicating a complex immune microenvironment post-SCI. Using WGCNA, we constructed a scale-free co-expression network and identified nine modules; the green module showed the strongest positive correlation with SCI. Intersecting DEGs, WGCNA module genes, and random forest-selected features identified five candidate genes: MAP3K6, ATP5MPL, NDUFB1, RNASE2 and MIR373. Single-cell RNA sequencing further revealed that MAP3K6 exhibited the highest expression among candidates, predominantly in neuroepithelial and neuronal cells. Validation in independent GSE151371 dataset confirmed significantly elevated MAP3K6 expression in SCI, with ROC analysis demonstrating robust diagnostic efficacy (AUC = 0.918). , MAP3K6 knockdown in mouse spinal cord neuronal cells promoted cell growth and inhibited apoptosis, decreasing pro-apoptotic proteins (BAX, caspase-3, cleaved caspase-3) and increasing anti-apoptotic Bcl-2. Collectively, our multi-omics analysis integrated with experimental validation identifies MAP3K6 as a key regulator in SCI pathogenesis, offering new insights into molecular mechanisms and highlighting its potential as a diagnostic biomarker and therapeutic target. - Source: PubMed
Publication date: 2026/03/09
Liu YanbingLiu ZhaoShi Yiqing