BMP3 Antibody
- Known as:
- BMP3 Antibody
- Catalog number:
- csb-pa002739la01hu
- Product Quantity:
- USD
- Category:
- -
- Supplier:
- CusAb
- Gene target:
- BMP3 Antibody
Related genes to: BMP3 Antibody
- Gene:
- BMP3 NIH gene
- Name:
- bone morphogenetic protein 3
- Previous symbol:
- -
- Synonyms:
- -
- Chromosome:
- 4q21.21
- Locus Type:
- gene with protein product
- Date approved:
- 1990-06-11
- Date modifiied:
- 2016-10-05
Related products to: BMP3 Antibody
Related articles to: BMP3 Antibody
- Despite advances in therapy, pulmonary arterial hypertension (PAH) remains progressive with poor survival. Although dysregulation of Bone Morphogenetic Protein (BMP) signaling is central to PAH, key modulators of this pathway remain incompletely defined. - Source: PubMed
Publication date: 2026/07/30
Halouani AymenMensah EricBen Rhouma MariemAthumani ZaujiaKatz Michael GImani SeunAntar Samar AJankowski KatherineMansoori MaryamRosen VickiIshikawa KiyotakeHadri LahouariaSassi Yassine - Animal models of enhanced fertility are rare, as most genetically modified mouse models with reproductive phenotype display subfertility or infertility. Here, we describe the ovarian phenotype of the Dummerstorf line 2 (FL2) mouse strain, which exhibits high fertility and has been selectively bred for increased fertility over more than 190 generations. This long-term selection, outbred mouse line almost doubled the litter size to 21.5 (FL2) compared with 11.3 (unselected control line, ctrl), without showing any signs of growth retardation in the offspring. Here, we show that FL2 females ovulate 25.0 oocytes per cycle compared with 13.2 in ctrl. FL2 mice remain in the estrus phase for a shorter period during a 12-day observation period. Follicle-stimulating hormone (FSH) levels are decreased, both in estrus and diestrus, compared with ctrl, whereas luteinizing hormone levels are unaffected. The mRNA expression levels in the pituitary gland correspond to the gonadotropin levels in the blood. Progesterone levels are decreased in estrus in FL2. Hypothalamic expression levels of gonadotropin-releasing hormone (GnRH) are decreased in diestrus. Holistic gene expression analysis indicates complex and differential regulation in estrus and diestrus in ovaries of FL2 compared with ctrl. In particular, genes of the TGF-β pathway (such as Bmp3, Bmp7, and Inhba) and the Wnt pathway (such as Sfrp4 and Mkrn1) are differentially expressed in ovaries of FL2 females. These data indicate that reduced activity of the hypothalamic-pituitary-gonadal axis (in particular, lower levels of GnRH, FSH, and progesterone), combined with altered gene transcription in the ovaries, leads to higher ovulation rates in order to achieve the breeding objective of improved fertility. - Source: PubMed
Ludwig Carolin L MBohleber SimonBaufeld AnjaWirth Eva KLanghammer MartinaSchweizer UlrichMichaelis MartenWeitzel Joachim M - Due to high morbidity and mortality rates, colorectal cancer (CRC) poses the significant global health challenge, thus early screening is essential to improve patient outcomes. DNA methylation biomarkers have become pivotal tools for detection of CRC, moving from research to clinical use. Key methylation loci (SEPT9, BMP3, and NDRG4) have been identified through genome-wide association studies and candidate gene approaches, then validated with high-throughput technologies, such as methylation arrays and next-generation sequencing. This advancement has led to the creation of clinically approved assays. Notably, the sensitivity of the Cologuard assay for detection of CRC is 92%, while that of the Epi proColon assay is 70%-80%, both outperforming traditional methods like fecal immunochemical testing, which has a sensitivity of 74%. These assays offer non-invasive screening for both average- and high-risk groups, and aid in postoperative monitoring. However, significant challenges remain. Key issues include technical difficulties for detection of low-abundance methylation signals and standardization of sample processing methods. Clinically, managing false results and validating long-term efficacy are problematic. Ethical concerns about overdiagnosis and data privacy also require attention. Future efforts should prioritize technological advancements, like single-molecule sequencing and liquid biopsy integration, along with large-scale prospective studies to validate biomarker utility in diverse populations. Updated guidelines for standardized implementation are also crucial. This review underscores the pivotal role of methylation biomarkers to revolutionize screening of CRC, while stressing the need for interdisciplinary collaboration, and outlines a strategy to address current limitations, ultimately aiming to reduce the global impact of CRC. - Source: PubMed
Publication date: 2026/05/27
Huang YangfengJiang WeiKang Jianhong - Spontaneous intracerebral hemorrhage (ICH) is a devastating neurologic emergency with high mortality. The distribution of ICH subtypes differs by ancestry, with lobar ICH more prevalent in individuals of European ancestry and deep ICH more common in populations of East Asian ancestry, potentially reflecting distinct genetic predispositions. However, the genetic basis of ICH in populations of East Asian ancestry remains underexplored, partly due to the limited availability of large, ancestry-specific cohorts with adequate genomic data. - Source: PubMed
Publication date: 2026/05/13
Juan Yu-ChungKuo John SChen Hung-LinCho Der-YangLin Hung-LinCheng Yu-KaiGuo Jeng-HungLin Yu-HsiangChang Yu-JunHo Huai-PingHuang Yu-HanChen Chun-Chung - Obeticholic acid (OCA), a potent agonist of the bile salt-activated nuclear receptor farnesoid X receptor (FXR), accelerates liver hypertrophy after portal vein embolization (PVE), but the mechanisms underlying this effect are incompletely understood. In a rabbit model of PVE, New Zealand White rabbits received OCA (10 mg/kg/day) or vehicle by oral gavage before and after embolization. We quantified systemic and hepatic bile salt pools, profiled FXR-regulated genes in ileum and liver, and related these parameters to volumetric and histological indices of regeneration. OCA shifted bile salt composition towards a more hydrophobic profile and improved homeostasis, with earlier normalization of serum total bile salts, reduced bile salt content in the non-embolized (hypertrophic) lobe, and lower circulating levels of the hepatotoxic bile salt lithocholic acid. Serum lithocholic acid strongly and inversely correlated with both caudal liver volume gain and hepatocyte proliferation. In the hypertrophic lobe, OCA markedly suppressed expression of CYP7A1, reduced circulating levels of the bile salt synthesis marker 7-alpha-hydroxy-4-cholesten-3-one, and increased expression of the basolateral bile salt exporter SLC51A/B, consistent with reduced bile salt synthesis and enhanced sinusoidal efflux. OCA also induced the mitotic entry regulator CDC25B. RNA sequencing identified ileal and hepatic signaling candidates, including C1q subunits, bone morphogenetic protein 3 (BMP3), and Indian hedgehog (IHH), which correlated with liver growth. These data indicate that FXR agonism by OCA promotes PVE-induced liver regeneration by improving bile salt homeostasis and modulating gut-liver growth signaling, supporting further evaluation of FXR agonists to enhance future liver remnant hypertrophy before major hepatectomy. - Source: PubMed
Publication date: 2026/04/18
Chang XinweiOlthof Pim BJin HanChau StevenSoons Zitavan Eijk Hansvan Golen Rowanvan Gulik Thomas MJansen Peter LDamink Steven W M OldeHeger MichalSchaap Frank G